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Q4L9D7

- BETA_STAHJ

UniProt

Q4L9D7 - BETA_STAHJ

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Protein

Oxygen-dependent choline dehydrogenase

Gene
betA, SH0429
Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei473 – 4731 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 3730FAD By similarityAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciSHAE279808:GJX7-431-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenase (EC:1.1.99.1)
Short name:
CDH
Short name:
CHD
Alternative name(s):
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betA
Ordered Locus Names:SH0429
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000543: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568Oxygen-dependent choline dehydrogenaseUniRule annotationPRO_0000205603Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279808.SH0429.

Structurei

3D structure databases

ProteinModelPortaliQ4L9D7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiYLQYACT.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4L9D7-1 [UniParc]FASTAAdd to Basket

« Hide

MSKKNSYDYV IIGGGSAGSV LGNRLTEDKD KEVLVLEAGR SDYPWDLFIQ    50
MPAALMFPSG NRFYDWIYQT EEEPHMGRKV DHARGKVLGG SSSINGMIYQ 100
RGNPMDYEGW AEPEGMESWD FAHCLPYFKR LEKTYGATPF DQFRGHHGPI 150
KLKRGPATNP LFKSFFDAGV EAGYHKTKDV NGYRQEGFGP FDSQVHNGRR 200
VSASRAYLHP AMKRKNLTVK TRAFVTKIHF DGNKATGVTF KRNGRYHTVD 250
AGEVILSGGA FNTPQLLQLS GIGDAEFLKS KGIEPRMHLP GVGENFEDHL 300
EVYIQHECKE PVSLQPSLDV KRMPWIGLQW IFARKGAAAS NHFEGGAFVR 350
SNNQVAYPNL MFHFLPIAVR YDGQKAPVAH GYQVHVGPMY SNSRGSLKIK 400
SKDPFEKPSI VFNYLSTKED EQEWVEAIRV ARNILAQKAM DPYNGGEISP 450
GPSVQTDEEI LDWVRRDGET ALHPSCSAKM GPASDPMSVV DPLTMKVHGM 500
ENLRVVDASA MPRTTNGNIH APVLMLAEKA ADIIRGKKPL EPQYVDYYKH 550
GVSDENAGAM EFDPYYQH 568
Length:568
Mass (Da):63,553
Last modified:August 2, 2005 - v1
Checksum:iAAE7A8FC49494CA7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006716 Genomic DNA. Translation: BAE03738.1.
RefSeqiWP_011274755.1. NC_007168.1.
YP_252344.1. NC_007168.1.

Genome annotation databases

EnsemblBacteriaiBAE03738; BAE03738; SH0429.
GeneIDi3482376.
KEGGisha:SH0429.
PATRICi19616891. VBIStaHae67511_0422.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006716 Genomic DNA. Translation: BAE03738.1 .
RefSeqi WP_011274755.1. NC_007168.1.
YP_252344.1. NC_007168.1.

3D structure databases

ProteinModelPortali Q4L9D7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 279808.SH0429.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE03738 ; BAE03738 ; SH0429 .
GeneIDi 3482376.
KEGGi sha:SH0429.
PATRICi 19616891. VBIStaHae67511_0422.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi YLQYACT.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci SHAE279808:GJX7-431-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species."
    Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K.
    J. Bacteriol. 187:7292-7308(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCSC1435.

Entry informationi

Entry nameiBETA_STAHJ
AccessioniPrimary (citable) accession number: Q4L9D7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: August 2, 2005
Last modified: September 3, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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