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Q4L9D7

- BETA_STAHJ

UniProt

Q4L9D7 - BETA_STAHJ

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Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei473 – 4731UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 3730FADUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciSHAE279808:GJX7-431-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Ordered Locus Names:SH0429
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000543: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568Oxygen-dependent choline dehydrogenasePRO_0000205603Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279808.SH0429.

Structurei

3D structure databases

ProteinModelPortaliQ4L9D7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiYLQYACT.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4L9D7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKKNSYDYV IIGGGSAGSV LGNRLTEDKD KEVLVLEAGR SDYPWDLFIQ
60 70 80 90 100
MPAALMFPSG NRFYDWIYQT EEEPHMGRKV DHARGKVLGG SSSINGMIYQ
110 120 130 140 150
RGNPMDYEGW AEPEGMESWD FAHCLPYFKR LEKTYGATPF DQFRGHHGPI
160 170 180 190 200
KLKRGPATNP LFKSFFDAGV EAGYHKTKDV NGYRQEGFGP FDSQVHNGRR
210 220 230 240 250
VSASRAYLHP AMKRKNLTVK TRAFVTKIHF DGNKATGVTF KRNGRYHTVD
260 270 280 290 300
AGEVILSGGA FNTPQLLQLS GIGDAEFLKS KGIEPRMHLP GVGENFEDHL
310 320 330 340 350
EVYIQHECKE PVSLQPSLDV KRMPWIGLQW IFARKGAAAS NHFEGGAFVR
360 370 380 390 400
SNNQVAYPNL MFHFLPIAVR YDGQKAPVAH GYQVHVGPMY SNSRGSLKIK
410 420 430 440 450
SKDPFEKPSI VFNYLSTKED EQEWVEAIRV ARNILAQKAM DPYNGGEISP
460 470 480 490 500
GPSVQTDEEI LDWVRRDGET ALHPSCSAKM GPASDPMSVV DPLTMKVHGM
510 520 530 540 550
ENLRVVDASA MPRTTNGNIH APVLMLAEKA ADIIRGKKPL EPQYVDYYKH
560
GVSDENAGAM EFDPYYQH
Length:568
Mass (Da):63,553
Last modified:August 2, 2005 - v1
Checksum:iAAE7A8FC49494CA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA. Translation: BAE03738.1.
RefSeqiWP_011274755.1. NC_007168.1.
YP_252344.1. NC_007168.1.

Genome annotation databases

EnsemblBacteriaiBAE03738; BAE03738; SH0429.
GeneIDi3482376.
KEGGisha:SH0429.
PATRICi19616891. VBIStaHae67511_0422.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA. Translation: BAE03738.1 .
RefSeqi WP_011274755.1. NC_007168.1.
YP_252344.1. NC_007168.1.

3D structure databases

ProteinModelPortali Q4L9D7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 279808.SH0429.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE03738 ; BAE03738 ; SH0429 .
GeneIDi 3482376.
KEGGi sha:SH0429.
PATRICi 19616891. VBIStaHae67511_0422.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi YLQYACT.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci SHAE279808:GJX7-431-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species."
    Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K.
    J. Bacteriol. 187:7292-7308(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCSC1435.

Entry informationi

Entry nameiBETA_STAHJ
AccessioniPrimary (citable) accession number: Q4L9D7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: August 2, 2005
Last modified: November 26, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3