Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q4L9D7 (BETA_STAHJ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Oxygen-dependent choline dehydrogenase

Short name=CDH
Short name=CHD
EC=1.1.99.1
Alternative name(s):
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betA
Ordered Locus Names:SH0429
OrganismStaphylococcus haemolyticus (strain JCSC1435) [Complete proteome] [HAMAP]
Taxonomic identifier279808 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length568 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity. HAMAP-Rule MF_00750

Catalytic activity

Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP-Rule MF_00750

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00750

Cofactor

FAD By similarity. HAMAP-Rule MF_00750

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP-Rule MF_00750

Sequence similarities

Belongs to the GMC oxidoreductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 568568Oxygen-dependent choline dehydrogenase HAMAP-Rule MF_00750
PRO_0000205603

Regions

Nucleotide binding8 – 3730FAD By similarity

Sites

Active site4731 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4L9D7 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: AAE7A8FC49494CA7

FASTA56863,553
        10         20         30         40         50         60 
MSKKNSYDYV IIGGGSAGSV LGNRLTEDKD KEVLVLEAGR SDYPWDLFIQ MPAALMFPSG 

        70         80         90        100        110        120 
NRFYDWIYQT EEEPHMGRKV DHARGKVLGG SSSINGMIYQ RGNPMDYEGW AEPEGMESWD 

       130        140        150        160        170        180 
FAHCLPYFKR LEKTYGATPF DQFRGHHGPI KLKRGPATNP LFKSFFDAGV EAGYHKTKDV 

       190        200        210        220        230        240 
NGYRQEGFGP FDSQVHNGRR VSASRAYLHP AMKRKNLTVK TRAFVTKIHF DGNKATGVTF 

       250        260        270        280        290        300 
KRNGRYHTVD AGEVILSGGA FNTPQLLQLS GIGDAEFLKS KGIEPRMHLP GVGENFEDHL 

       310        320        330        340        350        360 
EVYIQHECKE PVSLQPSLDV KRMPWIGLQW IFARKGAAAS NHFEGGAFVR SNNQVAYPNL 

       370        380        390        400        410        420 
MFHFLPIAVR YDGQKAPVAH GYQVHVGPMY SNSRGSLKIK SKDPFEKPSI VFNYLSTKED 

       430        440        450        460        470        480 
EQEWVEAIRV ARNILAQKAM DPYNGGEISP GPSVQTDEEI LDWVRRDGET ALHPSCSAKM 

       490        500        510        520        530        540 
GPASDPMSVV DPLTMKVHGM ENLRVVDASA MPRTTNGNIH APVLMLAEKA ADIIRGKKPL 

       550        560 
EPQYVDYYKH GVSDENAGAM EFDPYYQH 

« Hide

References

[1]"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species."
Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K.
J. Bacteriol. 187:7292-7308(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JCSC1435.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP006716 Genomic DNA. Translation: BAE03738.1.
RefSeqYP_252344.1. NC_007168.1.

3D structure databases

ProteinModelPortalQ4L9D7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING279808.SH0429.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAE03738; BAE03738; SH0429.
GeneID3482376.
KEGGsha:SH0429.
PATRIC19616891. VBIStaHae67511_0422.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2303.
HOGENOMHOG000139600.
KOK00108.
OMAYLQYACT.
OrthoDBEOG67HJQP.

Enzyme and pathway databases

BioCycSHAE279808:GJX7-431-MONOMER.
UniPathwayUPA00529; UER00385.

Family and domain databases

HAMAPMF_00750. Choline_dehydrogen.
InterProIPR011533. Choline_dehydrogenase.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsTIGR01810. betA. 1 hit.
PROSITEPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETA_STAHJ
AccessionPrimary (citable) accession number: Q4L9D7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: August 2, 2005
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways