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Q4L9B6

- ALF1_STAHJ

UniProt

Q4L9B6 - ALF1_STAHJ

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Protein
Fructose-bisphosphate aldolase class 1
Gene
fda, SH0450
Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei175 – 1751Proton acceptor By similarity
Active sitei212 – 2121Schiff-base intermediate with dihydroxyacetone-P By similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciSHAE279808:GJX7-452-MONOMER.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase class 1 (EC:4.1.2.13)
Alternative name(s):
Fructose-bisphosphate aldolase class I
Short name:
FBP aldolase
Gene namesi
Name:fda
Ordered Locus Names:SH0450
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000543: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 296295Fructose-bisphosphate aldolase class 1UniRule annotation
PRO_0000216912Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279808.SH0450.

Structurei

3D structure databases

ProteinModelPortaliQ4L9B6.
SMRiQ4L9B6. Positions 1-294.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3588.
HOGENOMiHOG000073502.
KOiK01623.
OMAiYTGDYLA.
OrthoDBiEOG6M6JJT.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00729. FBP_aldolase_1.
InterProiIPR013785. Aldolase_TIM.
IPR000741. FBA_I.
IPR023014. FBA_I_Gram+-type.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4L9B6-1 [UniParc]FASTAAdd to Basket

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MNKEQLEKMT NGKGFIAALD QSGGSTPKAL KEYGVNEDEY SNDDEMFQLV    50
HDMRTRVVTS PSFSPDKILG AILFEQTMDR EVEGKYTGDY LADKGVVPFL 100
KVDKGLAEQQ NGVQLMKPID DLDDTLDRAV ERHIFGTKMR SNILELNEQG 150
IKDVVEQQFE FAKKIIAKGL VPIIEPEVNI NAKDKAEIEE VLKAELKKGL 200
DALNDDQLVM LKLTIPTKAN LYKELADHPN VVRVVVLSGG YSRDEANKLL 250
KDNDELIASF SRALASDLRA SQSQEEFDKA LGDAVDSIYD ASVNKN 296
Length:296
Mass (Da):32,968
Last modified:January 23, 2007 - v3
Checksum:i619D6086BE604E71
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006716 Genomic DNA. Translation: BAE03759.1.
RefSeqiYP_252365.1. NC_007168.1.

Genome annotation databases

EnsemblBacteriaiBAE03759; BAE03759; SH0450.
GeneIDi3484099.
KEGGisha:SH0450.
PATRICi19616933. VBIStaHae67511_0443.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006716 Genomic DNA. Translation: BAE03759.1 .
RefSeqi YP_252365.1. NC_007168.1.

3D structure databases

ProteinModelPortali Q4L9B6.
SMRi Q4L9B6. Positions 1-294.
ModBasei Search...

Protein-protein interaction databases

STRINGi 279808.SH0450.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE03759 ; BAE03759 ; SH0450 .
GeneIDi 3484099.
KEGGi sha:SH0450.
PATRICi 19616933. VBIStaHae67511_0443.

Phylogenomic databases

eggNOGi COG3588.
HOGENOMi HOG000073502.
KOi K01623.
OMAi YTGDYLA.
OrthoDBi EOG6M6JJT.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .
BioCyci SHAE279808:GJX7-452-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00729. FBP_aldolase_1.
InterProi IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
IPR023014. FBA_I_Gram+-type.
[Graphical view ]
Pfami PF00274. Glycolytic. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species."
    Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K.
    J. Bacteriol. 187:7292-7308(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCSC1435.

Entry informationi

Entry nameiALF1_STAHJ
AccessioniPrimary (citable) accession number: Q4L9B6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 60 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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