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Q4L9B6

- ALF1_STAHJ

UniProt

Q4L9B6 - ALF1_STAHJ

Protein

Fructose-bisphosphate aldolase class 1

Gene

fda

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei175 – 1751Proton acceptorUniRule annotation
    Active sitei212 – 2121Schiff-base intermediate with dihydroxyacetone-PUniRule annotation

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    BioCyciSHAE279808:GJX7-452-MONOMER.
    UniPathwayiUPA00109; UER00183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase class 1UniRule annotation (EC:4.1.2.13UniRule annotation)
    Alternative name(s):
    Fructose-bisphosphate aldolase class I
    Short name:
    FBP aldolaseUniRule annotation
    Gene namesi
    Name:fdaUniRule annotation
    Ordered Locus Names:SH0450
    OrganismiStaphylococcus haemolyticus (strain JCSC1435)
    Taxonomic identifieri279808 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000543: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 296295Fructose-bisphosphate aldolase class 1PRO_0000216912Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi279808.SH0450.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4L9B6.
    SMRiQ4L9B6. Positions 1-294.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I fructose-bisphosphate aldolase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3588.
    HOGENOMiHOG000073502.
    KOiK01623.
    OMAiYTGDYLA.
    OrthoDBiEOG6M6JJT.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00729. FBP_aldolase_1.
    InterProiIPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    IPR023014. FBA_I_Gram+-type.
    [Graphical view]
    PfamiPF00274. Glycolytic. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q4L9B6-1 [UniParc]FASTAAdd to Basket

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    MNKEQLEKMT NGKGFIAALD QSGGSTPKAL KEYGVNEDEY SNDDEMFQLV    50
    HDMRTRVVTS PSFSPDKILG AILFEQTMDR EVEGKYTGDY LADKGVVPFL 100
    KVDKGLAEQQ NGVQLMKPID DLDDTLDRAV ERHIFGTKMR SNILELNEQG 150
    IKDVVEQQFE FAKKIIAKGL VPIIEPEVNI NAKDKAEIEE VLKAELKKGL 200
    DALNDDQLVM LKLTIPTKAN LYKELADHPN VVRVVVLSGG YSRDEANKLL 250
    KDNDELIASF SRALASDLRA SQSQEEFDKA LGDAVDSIYD ASVNKN 296
    Length:296
    Mass (Da):32,968
    Last modified:January 23, 2007 - v3
    Checksum:i619D6086BE604E71
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006716 Genomic DNA. Translation: BAE03759.1.
    RefSeqiYP_252365.1. NC_007168.1.

    Genome annotation databases

    EnsemblBacteriaiBAE03759; BAE03759; SH0450.
    GeneIDi3484099.
    KEGGisha:SH0450.
    PATRICi19616933. VBIStaHae67511_0443.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006716 Genomic DNA. Translation: BAE03759.1 .
    RefSeqi YP_252365.1. NC_007168.1.

    3D structure databases

    ProteinModelPortali Q4L9B6.
    SMRi Q4L9B6. Positions 1-294.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 279808.SH0450.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAE03759 ; BAE03759 ; SH0450 .
    GeneIDi 3484099.
    KEGGi sha:SH0450.
    PATRICi 19616933. VBIStaHae67511_0443.

    Phylogenomic databases

    eggNOGi COG3588.
    HOGENOMi HOG000073502.
    KOi K01623.
    OMAi YTGDYLA.
    OrthoDBi EOG6M6JJT.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00183 .
    BioCyci SHAE279808:GJX7-452-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00729. FBP_aldolase_1.
    InterProi IPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    IPR023014. FBA_I_Gram+-type.
    [Graphical view ]
    Pfami PF00274. Glycolytic. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species."
      Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K.
      J. Bacteriol. 187:7292-7308(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JCSC1435.

    Entry informationi

    Entry nameiALF1_STAHJ
    AccessioniPrimary (citable) accession number: Q4L9B6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 61 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3