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Q4L966 (ROCA_STAHJ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-pyrroline-5-carboxylate dehydrogenase
Short name=P5C dehydrogenase
EC=1.5.1.12
Gene names
Name:rocA
Ordered Locus Names:SH0500
OrganismStaphylococcus haemolyticus (strain JCSC1435) [Complete proteome] [HAMAP]
Taxonomic identifier279808 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length514 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-1-pyrroline-5-carboxylate + NAD(P)+ + 2 H2O = L-glutamate + NAD(P)H. HAMAP MF_00733

Pathway

Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2. HAMAP MF_00733

Sequence similarities

Belongs to the aldehyde dehydrogenase family. RocA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 5145141-pyrroline-5-carboxylate dehydrogenase HAMAP MF_00733
PRO_0000056522

Sites

Active site2861 By similarity
Active site3201 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4L966 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: 41AAD6873F1C7C86

FASTA51456,597
        10         20         30         40         50         60 
MVVPFKNEPG IDFSVQENVE RFQKTLEQVK NELGQTLPIV IDGEHITKDD TFDSINPANT 

        70         80         90        100        110        120 
SELIAKVSKA TKEDVDKAFE SSNKAYKAWR QWSHKDRAEL LLRVAAIIRR RKEEISAVMV 

       130        140        150        160        170        180 
YEAGKPWDEA VGDAAEGIDF IEYYARSMME LADGKPVLDR EGEHNKYFYK SIGTGVTIPP 

       190        200        210        220        230        240 
WNFPFAIMAG TTLAPVVAGN TVLLKPAEDT VLTAYKLIEI LEEAGLPKGV VNFVPGDPKE 

       250        260        270        280        290        300 
IGDYLVDSVH THFVTFTGSR ATGTRIYERS AVVQEGQTFL KRVIAEMGGK DAIVVDENID 

       310        320        330        340        350        360 
TDLAAESIIT SAFGFSGQKC SACSRAIVHS SVYDEVLEKA VALTKELTVG NTVDNTFMGP 

       370        380        390        400        410        420 
VINKKQFDKI KKYIEIGGKE GKIEIGGEAD DSTGYFIKPT IISGLKSSDQ VMQEEIFGPV 

       430        440        450        460        470        480 
VGFTKFDNFE EAIEIANDTD YGLTGAVITN NRENWIKAVN EFDVGNLYLN RGCTAAVVGY 

       490        500        510 
HPFGGFKMSG TDAKTGSPDY LLNFLEQKVV SEMF

« Hide

References

[1]"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species."
Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K.
J. Bacteriol. 187:7292-7308(2005) [PubMed: 16237012] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JCSC1435.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006716 Genomic DNA. Translation: BAE03809.1.
RefSeqYP_252415.1. NC_007168.1.

3D structure databases

ProteinModelPortalQ4L966.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ4L966.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000045978; EBSTAP00000044429; EBSTAG00000045975.
GeneID3481891.
GenomeReviewsGene locus SH0500 in contig AP006716_GR.
KEGGsha:SH0500.
NMPDRfig|279808.3.peg.589.
PATRIC19617033. VBIStaHae67511_0493.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
GeneTreeEBGT00050000023967.
HOGENOMHBG752218.
OMASINPANT.
PhylomeDBQ4L966.
ProtClustDBPRK03137.

Enzyme and pathway databases

BioCycSHAE279808:SH0500-MONOMER.

Family and domain databases

HAMAPMF_00733. RocA.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR005932. Delta1-pyrroline-5-COlate_DH-2.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK00294.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR01237. D1pyr5carbox2. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameROCA_STAHJ
AccessionPrimary (citable) accession number: Q4L966
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: August 2, 2005
Last modified: January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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