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Protein

Putative aldehyde dehydrogenase AldA

Gene

aldA

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei257 – 2571By similarity
Active sitei291 – 2911By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi213 – 2197NADBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSHAE279808:GJX7-549-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative aldehyde dehydrogenase AldA (EC:1.2.1.3)
Gene namesi
Name:aldA
Ordered Locus Names:SH0547
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000543 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Putative aldehyde dehydrogenase AldAPRO_0000056463Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279808.SH0547.

Structurei

3D structure databases

ProteinModelPortaliQ4L919.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00128.
OMAiGNTVAYH.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4L919-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVNVRDFI EEQYGLFING EFQASESGDT LTVTNPANGE DLAKVAKASK
60 70 80 90 100
SDVDKAVQAA QDAFDSWSKT SKEERADYLL EISRRIHEKV EHFATIESLQ
110 120 130 140 150
NGKPYRETST IDVPLTANQF KYFASVLTTD EGSVNEIDEN TMSLVVNEPV
160 170 180 190 200
GVVGAVVAWN FPILLASWKL APALAAGNTI VIQPSSSTPL SLIELAKIFQ
210 220 230 240 250
EVLPKGVVNV LTGKGSESGD AIFNHEGVNK LSFTGSTDVG YGVAKAGAER
260 270 280 290 300
IVPTTLELGG KSANIIFDDA NLDQVVEGAQ LGILFNQGEV CSAGSRLLVQ
310 320 330 340 350
SSIYDKVMPK LKEAFENIKV GDPFDEDVKM SAQTGPEQLE KIESYVKIAE
360 370 380 390 400
EDSNANILTG GHRLTDNGRD KGYFFEPTII EIKDNSHQLA QEEIFGPVVV
410 420 430 440 450
VEKFEDEAEA IKIANDSEYG LAGGIFTTNI NRALNVAKAM RTGRIWINTY
460 470 480 490
NQFPAGAPFG GYKKSGIGRE IYKDAIKNYQ QVKNIFIDTS NQTKGLY
Length:497
Mass (Da):54,119
Last modified:August 2, 2005 - v1
Checksum:i6BBC0B29CBED6B8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA. Translation: BAE03856.1.
RefSeqiWP_011274872.1. NC_007168.1.

Genome annotation databases

EnsemblBacteriaiBAE03856; BAE03856; SH0547.
GeneIDi24246341.
KEGGisha:SH0547.
PATRICi19617121. VBIStaHae67511_0537.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA. Translation: BAE03856.1.
RefSeqiWP_011274872.1. NC_007168.1.

3D structure databases

ProteinModelPortaliQ4L919.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi279808.SH0547.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAE03856; BAE03856; SH0547.
GeneIDi24246341.
KEGGisha:SH0547.
PATRICi19617121. VBIStaHae67511_0537.

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00128.
OMAiGNTVAYH.
OrthoDBiEOG6BS8QW.

Enzyme and pathway databases

BioCyciSHAE279808:GJX7-549-MONOMER.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species."
    Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K.
    J. Bacteriol. 187:7292-7308(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCSC1435.

Entry informationi

Entry nameiALDA_STAHJ
AccessioniPrimary (citable) accession number: Q4L919
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: August 2, 2005
Last modified: July 22, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.