Reviewed, UniProtKB/Swiss-Prot Q4L919 (ALDA_STAHJ)

Names and origin

Protein names

Recommended name:
    Putative aldehyde dehydrogenase aldA
    EC=1.2.1.3

Gene names

Name:	aldA
Ordered Locus Names:	SH0547

Organism

Staphylococcus haemolyticus (strain JCSC1435) [Complete proteome] [HAMAP]

Taxonomic identifier

279808 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	497 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	An aldehyde + NAD+ + H2O = an acid + NADH.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 497	497	Putative aldehyde dehydrogenase aldA		PRO_0000056463
Regions
	Nucleotide binding	213 – 219	7	NAD By similarity
Sites
	Active site	257	1	By similarity
	Active site	291	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4L919-1 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 6BBC0B29CBED6B8E	FASTA	497	54,119
	10 20 30 40 50 60 MAKVNVRDFI EEQYGLFING EFQASESGDT LTVTNPANGE DLAKVAKASK SDVDKAVQAA 70 80 90 100 110 120 QDAFDSWSKT SKEERADYLL EISRRIHEKV EHFATIESLQ NGKPYRETST IDVPLTANQF 130 140 150 160 170 180 KYFASVLTTD EGSVNEIDEN TMSLVVNEPV GVVGAVVAWN FPILLASWKL APALAAGNTI 190 200 210 220 230 240 VIQPSSSTPL SLIELAKIFQ EVLPKGVVNV LTGKGSESGD AIFNHEGVNK LSFTGSTDVG 250 260 270 280 290 300 YGVAKAGAER IVPTTLELGG KSANIIFDDA NLDQVVEGAQ LGILFNQGEV CSAGSRLLVQ 310 320 330 340 350 360 SSIYDKVMPK LKEAFENIKV GDPFDEDVKM SAQTGPEQLE KIESYVKIAE EDSNANILTG 370 380 390 400 410 420 GHRLTDNGRD KGYFFEPTII EIKDNSHQLA QEEIFGPVVV VEKFEDEAEA IKIANDSEYG 430 440 450 460 470 480 LAGGIFTTNI NRALNVAKAM RTGRIWINTY NQFPAGAPFG GYKKSGIGRE IYKDAIKNYQ 490 QVKNIFIDTS NQTKGLY

References

[1]

"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species." Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K. J. Bacteriol. 187:7292-7308(2005) [PubMed: 16237012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP006716 Genomic DNA. Translation: BAE03856.1.
RefSeq	YP_252462.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3482408.
GenomeReviews	Gene locus SH0547 in contig AP006716_GR.
KEGG	sha:SH0547.
NMPDR	fig|279808.3.peg.637.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4L919.
OMA	Q4L919. EDSNANI.
Enzyme and pathway databases
BioCyc	SHAE279808:SH0547-MON.
Family and domain databases
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDA_STAHJ

Accession

Primary (citable) accession number: Q4L919

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	August 2, 2005
Last modified:	June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)