ID   GTAB_STAHJ              Reviewed;         288 AA.
AC   Q4L8Y7;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   16-JUN-2009, entry version 23.
DE   RecName: Full=UTP--glucose-1-phosphate uridylyltransferase;
DE            EC=2.7.7.9;
DE   AltName: Full=UDP-glucose pyrophosphorylase;
DE            Short=UDPGP;
DE   AltName: Full=Alpha-D-glucosyl-1-phosphate uridylyltransferase;
DE   AltName: Full=Uridine diphosphoglucose pyrophosphorylase;
GN   Name=gtaB; OrderedLocusNames=SH0579;
OS   Staphylococcus haemolyticus (strain JCSC1435).
OC   Bacteria; Firmicutes; Bacillales; Staphylococcus.
OX   NCBI_TaxID=279808;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16237012; DOI=10.1128/JB.187.21.7292-7308.2005;
RA   Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA   Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S.,
RA   Lee J.C., Hiramatsu K.;
RT   "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT   extreme plasticity of its genome and the evolution of human-colonizing
RT   staphylococcal species.";
RL   J. Bacteriol. 187:7292-7308(2005).
CC   -!- FUNCTION: Catalyzes the formation of UDP-glucose from glucose-1-
CC       phosphate and UTP. This is an intermediate step in the
CC       biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. a
CC       glycolipid found in the membrane, which is also used as a membrane
CC       anchor for lipoteichoic acid (LTA) (By similarity).
CC   -!- CATALYTIC ACTIVITY: UTP + alpha-D-glucose 1-phosphate =
CC       diphosphate + UDP-glucose.
CC   -!- PATHWAY: Glycolipid metabolism; diglucosyl-diacylglycerol
CC       biosynthesis.
CC   -!- SIMILARITY: Belongs to the UDPGP type 2 family.
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DR   EMBL; AP006716; BAE03888.1; -; Genomic_DNA.
DR   RefSeq; YP_252494.1; -.
DR   GeneID; 3482172; -.
DR   GenomeReviews; AP006716_GR; SH0579.
DR   KEGG; sha:SH0579; -.
DR   NMPDR; fig|279808.3.peg.669; -.
DR   HOGENOM; Q4L8Y7; -.
DR   OMA; Q4L8Y7; DINICFI.
DR   BioCyc; SHAE279808:SH0579-MON; -.
DR   GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase...; IEA:EC.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR   InterPro; IPR005771; GalU_trans_bac.
DR   InterPro; IPR005835; NTP_transferase.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   TIGRFAMs; TIGR01099; galU; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Complete proteome; Nucleotidyltransferase;
KW   Transferase.
FT   CHAIN         1    288       UTP--glucose-1-phosphate
FT                                uridylyltransferase.
FT                                /FTId=PRO_0000308312.
SQ   SEQUENCE   288 AA;  32677 MW;  235203728F3AFB92 CRC64;
     MKQIKKAIIP AAGLGTRFLP ATKAMPKEML PILDKPTIQY IVEEASRAGI EDIIIVTGKH
     KRAIEDHFDN QKELEMVLEE KGKDDLLEKV QYSTDLANIF YVRQKEQKGL GHAIHTARQF
     IGNEPFAVLL GDDIVESETP AIKQLMNVYE ETGHSVIGVQ EVPESVTHRY GIIDPLEKEG
     RRYEVKQFVE KPKQGTAPSN LAIMGRYILT PEIFDYLETQ KEGAGNEIQL TDAIERMNSD
     IPVYAYDFDG DRYDVGEKLG FVKTTIEYAL KDPKMKDELI KFIKELGF
//