Reviewed, UniProtKB/Swiss-Prot Q4L8Y7 (GTAB_STAHJ)

Names and origin

Protein names

Recommended name:
    UTP--glucose-1-phosphate uridylyltransferase
    EC=2.7.7.9
Alternative name(s):
    UDP-glucose pyrophosphorylase
      Short name=UDPGP
    Alpha-D-glucosyl-1-phosphate uridylyltransferase
    Uridine diphosphoglucose pyrophosphorylase

Gene names

Name:	gtaB
Ordered Locus Names:	SH0579

Organism

Staphylococcus haemolyticus (strain JCSC1435) [Complete proteome] [HAMAP]

Taxonomic identifier

279808 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the formation of UDP-glucose from glucose-1-phosphate and UTP. This is an intermediate step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. a glycolipid found in the membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA) By similarity.
Catalytic activity	UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.
Pathway	Glycolipid metabolism; diglucosyl-diacylglycerol biosynthesis.
Sequence similarities	Belongs to the UDPGP type 2 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	UDP-glucose metabolic process Inferred from electronic annotation. Source: InterPro biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	UTP:glucose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 288	288	UTP--glucose-1-phosphate uridylyltransferase		PRO_0000308312

Sequences

	Sequence		Length	Mass (Da)
	Q4L8Y7-1 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 235203728F3AFB92	FASTA	288	32,677
	10 20 30 40 50 60 MKQIKKAIIP AAGLGTRFLP ATKAMPKEML PILDKPTIQY IVEEASRAGI EDIIIVTGKH 70 80 90 100 110 120 KRAIEDHFDN QKELEMVLEE KGKDDLLEKV QYSTDLANIF YVRQKEQKGL GHAIHTARQF 130 140 150 160 170 180 IGNEPFAVLL GDDIVESETP AIKQLMNVYE ETGHSVIGVQ EVPESVTHRY GIIDPLEKEG 190 200 210 220 230 240 RRYEVKQFVE KPKQGTAPSN LAIMGRYILT PEIFDYLETQ KEGAGNEIQL TDAIERMNSD 250 260 270 280 IPVYAYDFDG DRYDVGEKLG FVKTTIEYAL KDPKMKDELI KFIKELGF

References

[1]

"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species." Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K. J. Bacteriol. 187:7292-7308(2005) [PubMed: 16237012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006716 Genomic DNA. Translation: BAE03888.1.
RefSeq	YP_252494.1.
3D structure databases
SMR	Q4L8Y7. Positions 2-285.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4L8Y7.
Genome annotation databases
GeneID	3482172.
GenomeReviews	Gene locus SH0579 in contig AP006716_GR.
KEGG	sha:SH0579.
NMPDR	fig|279808.3.peg.669.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1210.
HOGENOM	HBG688195.
OMA	NERRYQV.
PhylomeDB	Q4L8Y7.
Enzyme and pathway databases
BioCyc	SHAE279808:SH0579-MONOMER.
Family and domain databases
InterPro	IPR005771. GalU_uridylyltTrfase_bac/arc. IPR005835. NTP_transferase. [Graphical view]
Pfam	PF00483. NTP_transferase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01099. galU. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GTAB_STAHJ

Accession

Primary (citable) accession number: Q4L8Y7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	August 2, 2005
Last modified:	February 9, 2010
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)