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Q4L8Y7

- GTAB_STAHJ

UniProt

Q4L8Y7 - GTAB_STAHJ

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Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

gtaB

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of UDP-glucose from glucose-1-phosphate and UTP. This is an intermediate step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. a glycolipid found in the membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA) (By similarity).By similarity

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Pathwayi

GO - Molecular functioni

  1. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. enterobacterial common antigen biosynthetic process Source: UniProtKB-UniPathway
  2. UDP-glucose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Carbohydrate metabolism

Enzyme and pathway databases

BioCyciSHAE279808:GJX7-581-MONOMER.
UniPathwayiUPA00894.

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Uridine diphosphoglucose pyrophosphorylase
Gene namesi
Name:gtaB
Ordered Locus Names:SH0579
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000543: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288UTP--glucose-1-phosphate uridylyltransferasePRO_0000308312Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279808.SH0579.

Structurei

3D structure databases

ProteinModelPortaliQ4L8Y7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDPGP type 2 family.Curated

Phylogenomic databases

eggNOGiCOG1210.
HOGENOMiHOG000283477.
KOiK00963.
OMAiKLIDECS.
OrthoDBiEOG6Z9B3V.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005771. GalU_uridylyltTrfase_bac/arc.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01099. galU. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4L8Y7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKQIKKAIIP AAGLGTRFLP ATKAMPKEML PILDKPTIQY IVEEASRAGI
60 70 80 90 100
EDIIIVTGKH KRAIEDHFDN QKELEMVLEE KGKDDLLEKV QYSTDLANIF
110 120 130 140 150
YVRQKEQKGL GHAIHTARQF IGNEPFAVLL GDDIVESETP AIKQLMNVYE
160 170 180 190 200
ETGHSVIGVQ EVPESVTHRY GIIDPLEKEG RRYEVKQFVE KPKQGTAPSN
210 220 230 240 250
LAIMGRYILT PEIFDYLETQ KEGAGNEIQL TDAIERMNSD IPVYAYDFDG
260 270 280
DRYDVGEKLG FVKTTIEYAL KDPKMKDELI KFIKELGF
Length:288
Mass (Da):32,677
Last modified:August 2, 2005 - v1
Checksum:i235203728F3AFB92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA. Translation: BAE03888.1.
RefSeqiWP_011274904.1. NC_007168.1.
YP_252494.1. NC_007168.1.

Genome annotation databases

EnsemblBacteriaiBAE03888; BAE03888; SH0579.
GeneIDi3482172.
KEGGisha:SH0579.
PATRICi19617181. VBIStaHae67511_0567.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA. Translation: BAE03888.1 .
RefSeqi WP_011274904.1. NC_007168.1.
YP_252494.1. NC_007168.1.

3D structure databases

ProteinModelPortali Q4L8Y7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 279808.SH0579.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE03888 ; BAE03888 ; SH0579 .
GeneIDi 3482172.
KEGGi sha:SH0579.
PATRICi 19617181. VBIStaHae67511_0567.

Phylogenomic databases

eggNOGi COG1210.
HOGENOMi HOG000283477.
KOi K00963.
OMAi KLIDECS.
OrthoDBi EOG6Z9B3V.

Enzyme and pathway databases

UniPathwayi UPA00894 .
BioCyci SHAE279808:GJX7-581-MONOMER.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR005771. GalU_uridylyltTrfase_bac/arc.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF00483. NTP_transferase. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
TIGRFAMsi TIGR01099. galU. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species."
    Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K.
    J. Bacteriol. 187:7292-7308(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCSC1435.

Entry informationi

Entry nameiGTAB_STAHJ
AccessioniPrimary (citable) accession number: Q4L8Y7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: August 2, 2005
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3