Q4L8Y7 (GTAB_STAHJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UTP--glucose-1-phosphate uridylyltransferase
EC=2.7.7.9

Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase
UDP-glucose pyrophosphorylase
Short name=UDPGP
Uridine diphosphoglucose pyrophosphorylase

Gene names

Name:	gtaB
Ordered Locus Names:	SH0579

Organism

Staphylococcus haemolyticus (strain JCSC1435) [Complete proteome] [HAMAP]

Taxonomic identifier

279808 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus haemolyticus

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the formation of UDP-glucose from glucose-1-phosphate and UTP. This is an intermediate step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. a glycolipid found in the membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA) By similarity.
Catalytic activity	UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.
Pathway	Glycolipid metabolism; diglucosyl-diacylglycerol biosynthesis.
Sequence similarities	Belongs to the UDPGP type 2 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	UDP-glucose metabolic process Inferred from electronic annotation. Source: InterPro enterobacterial common antigen biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	UTP:glucose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 288	288	UTP--glucose-1-phosphate uridylyltransferase		PRO_0000308312

Sequences

	Sequence		Length	Mass (Da)
	Q4L8Y7 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 235203728F3AFB92	FASTA	288	32,677
	10 20 30 40 50 60 MKQIKKAIIP AAGLGTRFLP ATKAMPKEML PILDKPTIQY IVEEASRAGI EDIIIVTGKH 70 80 90 100 110 120 KRAIEDHFDN QKELEMVLEE KGKDDLLEKV QYSTDLANIF YVRQKEQKGL GHAIHTARQF 130 140 150 160 170 180 IGNEPFAVLL GDDIVESETP AIKQLMNVYE ETGHSVIGVQ EVPESVTHRY GIIDPLEKEG 190 200 210 220 230 240 RRYEVKQFVE KPKQGTAPSN LAIMGRYILT PEIFDYLETQ KEGAGNEIQL TDAIERMNSD 250 260 270 280 IPVYAYDFDG DRYDVGEKLG FVKTTIEYAL KDPKMKDELI KFIKELGF

References

[1]

"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species." Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K. J. Bacteriol. 187:7292-7308(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JCSC1435.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006716 Genomic DNA. Translation: BAE03888.1.
RefSeq	YP_252494.1. NC_007168.1.
3D structure databases
ProteinModelPortal	Q4L8Y7.
ModBase	Search...
Protein-protein interaction databases
STRING	279808.SH0579.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAE03888; BAE03888; SH0579.
GeneID	3482172.
KEGG	sha:SH0579.
PATRIC	19617181. VBIStaHae67511_0567.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1210.
HOGENOM	HOG000283477.
KO	K00963.
OMA	IATMEVP.
ProtClustDB	CLSK746178.
Enzyme and pathway databases
BioCyc	SHAE279808:GJX7-581-MONOMER.
UniPathway	UPA00894.
Family and domain databases
InterPro	IPR005771. GalU_uridylyltTrfase_bac/arc. IPR005835. NTP_transferase. [Graphical view]
Pfam	PF00483. NTP_transferase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01099. galU. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GTAB_STAHJ

Accession

Primary (citable) accession number: Q4L8Y7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	August 2, 2005
Last modified:	May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program