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Q4L8Y7

- GTAB_STAHJ

UniProt

Q4L8Y7 - GTAB_STAHJ

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Protein
UTP--glucose-1-phosphate uridylyltransferase
Gene
gtaB, SH0579
Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of UDP-glucose from glucose-1-phosphate and UTP. This is an intermediate step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. a glycolipid found in the membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA) By similarity.

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Pathwayi

GO - Molecular functioni

  1. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. UDP-glucose metabolic process Source: InterPro
  2. enterobacterial common antigen biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Carbohydrate metabolism

Enzyme and pathway databases

BioCyciSHAE279808:GJX7-581-MONOMER.
UniPathwayiUPA00894.

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Uridine diphosphoglucose pyrophosphorylase
Gene namesi
Name:gtaB
Ordered Locus Names:SH0579
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000543: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288UTP--glucose-1-phosphate uridylyltransferase
PRO_0000308312Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279808.SH0579.

Structurei

3D structure databases

ProteinModelPortaliQ4L8Y7.

Family & Domainsi

Sequence similaritiesi

Belongs to the UDPGP type 2 family.

Phylogenomic databases

eggNOGiCOG1210.
HOGENOMiHOG000283477.
KOiK00963.
OMAiKLIDECS.
OrthoDBiEOG6Z9B3V.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005771. GalU_uridylyltTrfase_bac/arc.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01099. galU. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4L8Y7-1 [UniParc]FASTAAdd to Basket

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MKQIKKAIIP AAGLGTRFLP ATKAMPKEML PILDKPTIQY IVEEASRAGI    50
EDIIIVTGKH KRAIEDHFDN QKELEMVLEE KGKDDLLEKV QYSTDLANIF 100
YVRQKEQKGL GHAIHTARQF IGNEPFAVLL GDDIVESETP AIKQLMNVYE 150
ETGHSVIGVQ EVPESVTHRY GIIDPLEKEG RRYEVKQFVE KPKQGTAPSN 200
LAIMGRYILT PEIFDYLETQ KEGAGNEIQL TDAIERMNSD IPVYAYDFDG 250
DRYDVGEKLG FVKTTIEYAL KDPKMKDELI KFIKELGF 288
Length:288
Mass (Da):32,677
Last modified:August 2, 2005 - v1
Checksum:i235203728F3AFB92
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006716 Genomic DNA. Translation: BAE03888.1.
RefSeqiYP_252494.1. NC_007168.1.

Genome annotation databases

EnsemblBacteriaiBAE03888; BAE03888; SH0579.
GeneIDi3482172.
KEGGisha:SH0579.
PATRICi19617181. VBIStaHae67511_0567.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006716 Genomic DNA. Translation: BAE03888.1 .
RefSeqi YP_252494.1. NC_007168.1.

3D structure databases

ProteinModelPortali Q4L8Y7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 279808.SH0579.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE03888 ; BAE03888 ; SH0579 .
GeneIDi 3482172.
KEGGi sha:SH0579.
PATRICi 19617181. VBIStaHae67511_0567.

Phylogenomic databases

eggNOGi COG1210.
HOGENOMi HOG000283477.
KOi K00963.
OMAi KLIDECS.
OrthoDBi EOG6Z9B3V.

Enzyme and pathway databases

UniPathwayi UPA00894 .
BioCyci SHAE279808:GJX7-581-MONOMER.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR005771. GalU_uridylyltTrfase_bac/arc.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF00483. NTP_transferase. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
TIGRFAMsi TIGR01099. galU. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species."
    Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K.
    J. Bacteriol. 187:7292-7308(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCSC1435.

Entry informationi

Entry nameiGTAB_STAHJ
AccessioniPrimary (citable) accession number: Q4L8Y7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: August 2, 2005
Last modified: June 11, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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