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Protein

Polyphosphate kinase

Gene

ppk

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).UniRule annotation

Catalytic activityi

ATP + (phosphate)(n) = ADP + (phosphate)(n+1).UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei54ATPUniRule annotation1
Metal bindingi379MagnesiumUniRule annotation1
Metal bindingi409MagnesiumUniRule annotation1
Active sitei439Phosphohistidine intermediateUniRule annotation1
Binding sitei472ATPUniRule annotation1
Binding sitei568ATPUniRule annotation1
Binding sitei596ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyphosphate kinaseUniRule annotation (EC:2.7.4.1UniRule annotation)
Alternative name(s):
ATP-polyphosphate phosphotransferaseUniRule annotation
Polyphosphoric acid kinaseUniRule annotation
Gene namesi
Name:ppkUniRule annotation
Ordered Locus Names:SH0587
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000543 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001286591 – 721Polyphosphate kinaseAdd BLAST721

Post-translational modificationi

An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi279808.SH0587.

Structurei

3D structure databases

ProteinModelPortaliQ4L8X9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini434 – 468PLD phosphodiesteraseUniRule annotationAdd BLAST35

Sequence similaritiesi

Belongs to the polyphosphate kinase family.UniRule annotation
Contains 1 PLD phosphodiesterase domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CUU. Bacteria.
COG0855. LUCA.
HOGENOMiHOG000248948.
KOiK00937.
OMAiLSSMIHA.
OrthoDBiPOG091H02MN.

Family and domain databases

Gene3Di3.30.1840.10. 1 hit.
HAMAPiMF_00347. Polyphosphate_kinase. 1 hit.
InterProiIPR003414. PP_kinase.
IPR024953. PP_kinase_middle.
IPR025200. PPK_C_dom.
IPR025198. PPK_N_dom.
[Graphical view]
PfamiPF02503. PP_kinase. 1 hit.
PF13090. PP_kinase_C. 1 hit.
PF13089. PP_kinase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF015589. PP_kinase. 1 hit.
SUPFAMiSSF140356. SSF140356. 1 hit.
TIGRFAMsiTIGR03705. poly_P_kin. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4L8X9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTQLGENDI SLPQYYNNRE LSWLDFNYRV LQEAYDKNNP LLEKLNFISI
60 70 80 90 100
FSSNLDEFFM VRVAGLKDQV KMGYDKPENK AQMTPQEQVD AIQEKAKKYV
110 120 130 140 150
DTQYERYNEL MIELKDYEIV MCEPHELSEP LLSKLERDFK LTILPTLTPL
160 170 180 190 200
GIDAYHPFPK LNNKSLNIFV DIDTEDAINS AIVQIPSLIP RFLTYNEGAK
210 220 230 240 250
QYVVMVEDVI TYFINYLFTG YEVLNTFTFR ITRNADLTIH EDGAEDLLIE
260 270 280 290 300
IERFLKERKS GSAVRLEVDG RTENPDDLDW LIETLEVDKQ DVYFLNGPLD
310 320 330 340 350
LTFIFGLVDH LSHKLNYLTY EKYSPQIPRS LGNNNLYELA LKRDIFFHHP
360 370 380 390 400
YESFEPIVDF IREAADDPNT IAIKQTLYRV SKDSPIIKSL KEAAEKGKQV
410 420 430 440 450
TVLVELKARF DEENNVHWAR MLEDAGCHVI YGMTHLKTHS KIALVVKRIG
460 470 480 490 500
GELTSFVHLG TGNYNDKTAK LYTDMGIITT NEQIAEDAIN FFNYLSGYSV
510 520 530 540 550
KPEYNKLIVA PFDIRDVFID RIDKEISSHL QHGNGKIMMK MNSLTDKAII
560 570 580 590 600
EKLFEASQAG VKIQLIIRGI CCLKPGIPGI SENIEVVSIV GRLLEHSRIY
610 620 630 640 650
YFHNNGDERI YLSSADVMTR NMIKRVEILF PVEDKEIGKR LVDFMDLQLS
660 670 680 690 700
DNQKGRYQDE HGHYHYVENN LSPLNSQVYL MQEAIKYGQE LKKRSAQPSG
710 720
MPVVSKRRAN WMNRIRRSLK K
Length:721
Mass (Da):83,509
Last modified:August 2, 2005 - v1
Checksum:i29790C9C1D4F92C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA. Translation: BAE03896.1.
RefSeqiWP_011274912.1. NC_007168.1.

Genome annotation databases

EnsemblBacteriaiBAE03896; BAE03896; SH0587.
GeneIDi24247204.
KEGGisha:SH0587.
PATRICi19617197. VBIStaHae67511_0575.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA. Translation: BAE03896.1.
RefSeqiWP_011274912.1. NC_007168.1.

3D structure databases

ProteinModelPortaliQ4L8X9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi279808.SH0587.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAE03896; BAE03896; SH0587.
GeneIDi24247204.
KEGGisha:SH0587.
PATRICi19617197. VBIStaHae67511_0575.

Phylogenomic databases

eggNOGiENOG4105CUU. Bacteria.
COG0855. LUCA.
HOGENOMiHOG000248948.
KOiK00937.
OMAiLSSMIHA.
OrthoDBiPOG091H02MN.

Family and domain databases

Gene3Di3.30.1840.10. 1 hit.
HAMAPiMF_00347. Polyphosphate_kinase. 1 hit.
InterProiIPR003414. PP_kinase.
IPR024953. PP_kinase_middle.
IPR025200. PPK_C_dom.
IPR025198. PPK_N_dom.
[Graphical view]
PfamiPF02503. PP_kinase. 1 hit.
PF13090. PP_kinase_C. 1 hit.
PF13089. PP_kinase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF015589. PP_kinase. 1 hit.
SUPFAMiSSF140356. SSF140356. 1 hit.
TIGRFAMsiTIGR03705. poly_P_kin. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPPK_STAHJ
AccessioniPrimary (citable) accession number: Q4L8X9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: August 2, 2005
Last modified: November 30, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.