Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Polyphosphate kinase

Gene

ppk

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).UniRule annotation

Catalytic activityi

ATP + (phosphate)(n) = ADP + (phosphate)(n+1).UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei54ATPUniRule annotation1
Metal bindingi379MagnesiumUniRule annotation1
Metal bindingi409MagnesiumUniRule annotation1
Active sitei439Phosphohistidine intermediateUniRule annotation1
Binding sitei472ATPUniRule annotation1
Binding sitei568ATPUniRule annotation1
Binding sitei596ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSHAE279808:G1G27-549-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Polyphosphate kinaseUniRule annotation (EC:2.7.4.1UniRule annotation)
Alternative name(s):
ATP-polyphosphate phosphotransferaseUniRule annotation
Polyphosphoric acid kinaseUniRule annotation
Gene namesi
Name:ppkUniRule annotation
Ordered Locus Names:SH0587
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001286591 – 721Polyphosphate kinaseAdd BLAST721

Post-translational modificationi

An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.UniRule annotation

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ4L8X9

Interactioni

Protein-protein interaction databases

STRINGi279808.SH0587

Structurei

3D structure databases

ProteinModelPortaliQ4L8X9
SMRiQ4L8X9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini434 – 468PLD phosphodiesteraseUniRule annotationAdd BLAST35

Sequence similaritiesi

Belongs to the polyphosphate kinase 1 (PPK1) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CUU Bacteria
COG0855 LUCA
HOGENOMiHOG000248948
KOiK00937
OMAiQIMVANL
OrthoDBiPOG091H02MN

Family and domain databases

Gene3Di3.30.1840.10, 1 hit
HAMAPiMF_00347 Polyphosphate_kinase, 1 hit
InterProiView protein in InterPro
IPR003414 PP_kinase
IPR024953 PP_kinase_middle
IPR036830 PP_kinase_middle_dom_sf
IPR025200 PPK_C_dom
IPR025198 PPK_N_dom
IPR036832 PPK_N_dom_sf
PANTHERiPTHR30218 PTHR30218, 1 hit
PfamiView protein in Pfam
PF02503 PP_kinase, 1 hit
PF13090 PP_kinase_C, 1 hit
PF13089 PP_kinase_N, 1 hit
PIRSFiPIRSF015589 PP_kinase, 1 hit
SUPFAMiSSF140356 SSF140356, 1 hit
TIGRFAMsiTIGR03705 poly_P_kin, 1 hit

Sequencei

Sequence statusi: Complete.

Q4L8X9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTQLGENDI SLPQYYNNRE LSWLDFNYRV LQEAYDKNNP LLEKLNFISI
60 70 80 90 100
FSSNLDEFFM VRVAGLKDQV KMGYDKPENK AQMTPQEQVD AIQEKAKKYV
110 120 130 140 150
DTQYERYNEL MIELKDYEIV MCEPHELSEP LLSKLERDFK LTILPTLTPL
160 170 180 190 200
GIDAYHPFPK LNNKSLNIFV DIDTEDAINS AIVQIPSLIP RFLTYNEGAK
210 220 230 240 250
QYVVMVEDVI TYFINYLFTG YEVLNTFTFR ITRNADLTIH EDGAEDLLIE
260 270 280 290 300
IERFLKERKS GSAVRLEVDG RTENPDDLDW LIETLEVDKQ DVYFLNGPLD
310 320 330 340 350
LTFIFGLVDH LSHKLNYLTY EKYSPQIPRS LGNNNLYELA LKRDIFFHHP
360 370 380 390 400
YESFEPIVDF IREAADDPNT IAIKQTLYRV SKDSPIIKSL KEAAEKGKQV
410 420 430 440 450
TVLVELKARF DEENNVHWAR MLEDAGCHVI YGMTHLKTHS KIALVVKRIG
460 470 480 490 500
GELTSFVHLG TGNYNDKTAK LYTDMGIITT NEQIAEDAIN FFNYLSGYSV
510 520 530 540 550
KPEYNKLIVA PFDIRDVFID RIDKEISSHL QHGNGKIMMK MNSLTDKAII
560 570 580 590 600
EKLFEASQAG VKIQLIIRGI CCLKPGIPGI SENIEVVSIV GRLLEHSRIY
610 620 630 640 650
YFHNNGDERI YLSSADVMTR NMIKRVEILF PVEDKEIGKR LVDFMDLQLS
660 670 680 690 700
DNQKGRYQDE HGHYHYVENN LSPLNSQVYL MQEAIKYGQE LKKRSAQPSG
710 720
MPVVSKRRAN WMNRIRRSLK K
Length:721
Mass (Da):83,509
Last modified:August 2, 2005 - v1
Checksum:i29790C9C1D4F92C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA Translation: BAE03896.1
RefSeqiWP_011274912.1, NC_007168.1

Genome annotation databases

EnsemblBacteriaiBAE03896; BAE03896; SH0587
GeneIDi24247204
KEGGisha:SH0587

Entry informationi

Entry nameiPPK1_STAHJ
AccessioniPrimary (citable) accession number: Q4L8X9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: August 2, 2005
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health