Q4L8T0 (GPMA_STAHJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
Short name=BPG-dependent PGAM
Short name=PGAM
Short name=Phosphoglyceromutase
Short name=dPGM
EC=5.4.2.1

Gene names

Name:	gpmA
Ordered Locus Names:	SH0636

Organism

Staphylococcus haemolyticus (strain JCSC1435) [Complete proteome] [HAMAP]

Taxonomic identifier

279808 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus haemolyticus

Protein attributes

Sequence length	228 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity. HAMAP-Rule MF_01039
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP-Rule MF_01039
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP-Rule MF_01039
Sequence similarities	Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: HAMAP
Molecular_function	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 228	228	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase HAMAP-Rule MF_01039		PRO_0000179918
Sites
	Active site	9	1	Tele-phosphohistidine intermediate By similarity
	Active site	182	1	By similarity
	Site	60	1	Interaction with carboxyl group of phosphoglycerates By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4L8T0 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 0C65EFA7A78A02F4	FASTA	228	26,735
	10 20 30 40 50 60 MPKLILCRHG QSEWNAKNLF TGWEDVQLSE QGRNEAITSG RKLKENGIEI DVAFTSLLTR 70 80 90 100 110 120 ALETTQFLLA ESDQEWIPVH KSWRLNERHY GKLQGLNKDE ARKEFGEEQV HQWRRSYDVK 130 140 150 160 170 180 PPAQTEEQRE SYLKDRRYRH LDHRMMPYSE SLKTTLERVV PIWTDKISQH LLDGETVLVA 190 200 210 220 AHGNSIRALI KYLDNVSDED IIGYEIKTGA PLIYELDDNL NVIDHYYL

References

[1]

"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species." Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K. J. Bacteriol. 187:7292-7308(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JCSC1435.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006716 Genomic DNA. Translation: BAE03945.1.
RefSeq	YP_252551.1. NC_007168.1.
3D structure databases
ProteinModelPortal	Q4L8T0.
SMR	Q4L8T0. Positions 3-228.
ModBase	Search...
Protein-protein interaction databases
STRING	279808.SH0636.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAE03945; BAE03945; SH0636.
GeneID	3482202.
KEGG	sha:SH0636.
PATRIC	19617295. VBIStaHae67511_0624.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0588.
HOGENOM	HOG000221682.
KO	K01834.
OMA	GQSDWNL.
ProtClustDB	PRK14119.
Enzyme and pathway databases
BioCyc	SHAE279808:GJX7-638-MONOMER.
UniPathway	UPA00109; UER00186.
Family and domain databases
HAMAP	MF_01039. PGAM_GpmA.
InterPro	IPR013078. His_Pase_superF_clade-1. IPR001345. PG/BPGM_mutase_AS. IPR005952. Phosphogly_mut1. [Graphical view]
PANTHER	PTHR11931. PTHR11931. 1 hit.
Pfam	PF00300. His_Phos_1. 1 hit. [Graphical view]
SMART	SM00855. PGAM. 1 hit. [Graphical view]
TIGRFAMs	TIGR01258. pgm_1. 1 hit.
PROSITE	PS00175. PG_MUTASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPMA_STAHJ

Accession

Primary (citable) accession number: Q4L8T0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	August 2, 2005
Last modified:	May 1, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program