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Protein

Oxygen regulatory protein NreC

Gene

nreC

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. Phosphorylated NreC binds to a GC-rich palindromic sequence at the promoters of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT, and activates their expression (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi172 – 191H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation, Two-component regulatory system

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen regulatory protein NreC
Alternative name(s):
Nitrogen regulation protein C
Gene namesi
Name:nreC
Ordered Locus Names:SH0660
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000543 Componenti: Chromosome

Subcellular locationi

Q4L8Q6:

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003493591 – 217Oxygen regulatory protein NreCAdd BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei534-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Phosphorylated by NreB.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi279808.SH0660.

Structurei

3D structure databases

ProteinModelPortaliQ4L8Q6.
SMRiQ4L8Q6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 119Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini148 – 213HTH luxR-typePROSITE-ProRule annotationAdd BLAST66

Phylogenomic databases

eggNOGiENOG4105WH1. Bacteria.
COG2197. LUCA.
HOGENOMiHOG000034813.
KOiK07696.
OMAiSHKTRIM.
OrthoDBiPOG091H05B9.

Family and domain databases

CDDicd06170. LuxR_C_like. 1 hit.
cd00156. REC. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR011006. CheY-like_superfamily.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR000792. Tscrpt_reg_LuxR_C.
IPR036388. WH-like_DNA-bd_sf.
PfamiView protein in Pfam
PF00196. GerE. 1 hit.
PF00072. Response_reg. 1 hit.
PRINTSiPR00038. HTHLUXR.
SMARTiView protein in SMART
SM00421. HTH_LUXR. 1 hit.
SM00448. REC. 1 hit.
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiView protein in PROSITE
PS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4L8Q6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIVIADDHA VVRTGFSMIL NFQEDMEVVA TAADGGEAYQ KVMEHKPDVL
60 70 80 90 100
IMDLSMPPGE SGLIATSKIS ESFPETKILI LTMYDDEEYL FHVLRNGAKG
110 120 130 140 150
YILKNAPDEQ LLLAVRTVYK GETYVDMKLT TSLVNEFVNH KHSDDVSTND
160 170 180 190 200
PFKILSKREL EILPLIAKGY GNKDIAEKLF VSVKTVEAHK THIMTKLDLK
210
SKPELVEYAL KKKLLDF
Length:217
Mass (Da):24,462
Last modified:August 2, 2005 - v1
Checksum:i3EC3FE0DBC02C553
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA. Translation: BAE03969.1.
RefSeqiWP_011274985.1. NC_007168.1.

Genome annotation databases

EnsemblBacteriaiBAE03969; BAE03969; SH0660.
GeneIDi24246720.
KEGGisha:SH0660.

Similar proteinsi

Entry informationi

Entry nameiNREC_STAHJ
AccessioniPrimary (citable) accession number: Q4L8Q6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: August 2, 2005
Last modified: October 25, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome