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Q4L8G8

- FDHL_STAHJ

UniProt

Q4L8G8 - FDHL_STAHJ

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Protein

Putative formate dehydrogenase SH0748

Gene

SH0748

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Formate + NAD+ = CO2 + NADH.

Cofactori

Binds 1 2Fe-2S cluster.By similarity
Binds 4 4Fe-4S clusters.By similarity
Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi37 – 371Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi48 – 481Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi51 – 511Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi63 – 631Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi95 – 951Iron-sulfur 2 (4Fe-4S); via tele nitrogenBy similarity
Metal bindingi99 – 991Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi102 – 1021Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi109 – 1091Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi147 – 1471Iron-sulfur 3 (4Fe-4S)By similarity
Metal bindingi150 – 1501Iron-sulfur 3 (4Fe-4S)By similarity
Metal bindingi153 – 1531Iron-sulfur 3 (4Fe-4S)By similarity
Metal bindingi157 – 1571Iron-sulfur 4 (4Fe-4S)By similarity
Metal bindingi190 – 1901Iron-sulfur 4 (4Fe-4S)By similarity
Metal bindingi193 – 1931Iron-sulfur 4 (4Fe-4S)By similarity
Metal bindingi196 – 1961Iron-sulfur 4 (4Fe-4S)By similarity
Metal bindingi200 – 2001Iron-sulfur 3 (4Fe-4S)By similarity
Metal bindingi264 – 2641Iron-sulfur 5 (4Fe-4S)By similarity
Metal bindingi267 – 2671Iron-sulfur 5 (4Fe-4S)By similarity
Metal bindingi271 – 2711Iron-sulfur 5 (4Fe-4S)By similarity
Metal bindingi299 – 2991Iron-sulfur 5 (4Fe-4S)By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  3. electron carrier activity Source: InterPro
  4. formate dehydrogenase (NAD+) activity Source: UniProtKB-EC
  5. molybdenum ion binding Source: InterPro

GO - Biological processi

  1. formate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD

Enzyme and pathway databases

BioCyciSHAE279808:GJX7-750-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative formate dehydrogenase SH0748 (EC:1.2.1.2)
Gene namesi
Ordered Locus Names:SH0748
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000543: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 984984Putative formate dehydrogenase SH0748PRO_0000304136Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279808.SH0748.

Structurei

3D structure databases

ProteinModelPortaliQ4L8G8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 79772Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
BLAST
Domaini138 – 165284Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini181 – 211314Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd
BLAST
Domaini257 – 313574Fe-4S Mo/W bis-MGD-typePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni252 – 984733Formate dehydrogenaseAdd
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.Curated
Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
Contains 2 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation
Contains 1 4Fe-4S Mo/W bis-MGD-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG3383.
HOGENOMiHOG000031440.
KOiK00123.
OMAiMHIDAFV.
OrthoDBiEOG6CVV7G.

Family and domain databases

InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR001450. 4Fe4S-bd_dom.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR009010. Asp_de-COase-like_dom.
IPR006478. Formate_DH_asu.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR006655. Mopterin_OxRdtase_prok_CS.
IPR027467. MopterinOxRdtase_cofactor_BS.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
[Graphical view]
PfamiPF12838. Fer4_7. 1 hit.
PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
PIRSFiPIRSF036643. FDH_alpha. 1 hit.
SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
SM00929. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR01591. Fdh-alpha. 1 hit.
PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4L8G8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQEHLIVTLD GTDYLVEPGT SLLEFIKSRD TFVPSICYNE SMGPIQTCDT
60 70 80 90 100
CMVEIDGKIE RACSTVVNRP MTVNTQNNDV KASQKEALDR ILEKHMLYCT
110 120 130 140 150
VCDYNNGDCE IHNAMDAWGL EEQSYEYKTK PYEKDYGPFY RYDPDQCILC
160 170 180 190 200
GRCVEACQDI EVNETISIDW NREHPRVIWD NDVPINESSC VSCGQCATVC
210 220 230 240 250
PCNAMMEVNM EGNAGYMTDT EPGSLAAMID LTKKAEPGDG LLFAVSDSEA
260 270 280 290 300
EMRKERIKKT KTVCTYCGVG CSFDVWTKDR EVLKVQPSHD SPANKIATCV
310 320 330 340 350
KGKFSWGHIN SDQRLTKPLV RKDGEFHEVE WDEALDVIET NFKRIKNEYG
360 370 380 390 400
GDHLAFIASS KGTNEESYLM QKLSRQVFGS NNVDNCSRYC QAPATKGLFR
410 420 430 440 450
TVGHGGDSGS IEDLERAAMT VLIGTNTAEA HPVIASRMKR AQKLFGQKMH
460 470 480 490 500
VFDIRKHEMA ARADAFYQPK PGTDLVWLGA ATKYIIDNDL HDKAFLNDWV
510 520 530 540 550
DNYEDYYKSL ELFTMDFAEE TTGIPKEQII SFAEEAAKAE SMSICWAMGV
560 570 580 590 600
TQQDIGSDTS TAISNLLLVT GNYRKPGSGA YPLRGHNNVQ GASDMGSMPD
610 620 630 640 650
QFPGYQKVAD DEVRAKFEKE YGVELNPTPG RDNHQMMEGI HNGDIQSLYL
660 670 680 690 700
YGEDTGIVDS NINFVQSALE KVDFLVVQDE FLTFTATYAD VVLPASPSLE
710 720 730 740 750
KDGTFTNTER RIQRINKALQ PLGDSKPDWE IFQLIAQRMG ADWNYKHPSE
760 770 780 790 800
IMDEIAGLTP SYSGVNYERL QGFNSLQWPV APDGTDQPTL YMDGFNFENG
810 820 830 840 850
RAKLFPLTFD NFFKEDEVYD LHVNNGRLLE HFHEGNMTYQ TEMIKYKVPN
860 870 880 890 900
AFVEISPELA KDRDIHEGAE LRLISETGEA TLIATVTDRV KGREIYIPLN
910 920 930 940 950
NDAMSNGDLG AINKLTNSDV DKYTDTPSYK RTSCRMEVLT RKGKSPLNPT
960 970 980
NFRVDKQRNP QYSVQVQKKW ERPDYVFPGN VVDK
Length:984
Mass (Da):110,941
Last modified:August 2, 2005 - v1
Checksum:iF0CCF0467C86D89F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006716 Genomic DNA. Translation: BAE04057.1.
RefSeqiYP_252663.1. NC_007168.1.

Genome annotation databases

EnsemblBacteriaiBAE04057; BAE04057; SH0748.
GeneIDi3483766.
KEGGisha:SH0748.
PATRICi19617516. VBIStaHae67511_0734.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006716 Genomic DNA. Translation: BAE04057.1 .
RefSeqi YP_252663.1. NC_007168.1.

3D structure databases

ProteinModelPortali Q4L8G8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 279808.SH0748.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE04057 ; BAE04057 ; SH0748 .
GeneIDi 3483766.
KEGGi sha:SH0748.
PATRICi 19617516. VBIStaHae67511_0734.

Phylogenomic databases

eggNOGi COG3383.
HOGENOMi HOG000031440.
KOi K00123.
OMAi MHIDAFV.
OrthoDBi EOG6CVV7G.

Enzyme and pathway databases

BioCyci SHAE279808:GJX7-750-MONOMER.

Family and domain databases

InterProi IPR001041. 2Fe-2S_ferredoxin-type.
IPR001450. 4Fe4S-bd_dom.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR009010. Asp_de-COase-like_dom.
IPR006478. Formate_DH_asu.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR006655. Mopterin_OxRdtase_prok_CS.
IPR027467. MopterinOxRdtase_cofactor_BS.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
[Graphical view ]
Pfami PF12838. Fer4_7. 1 hit.
PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF036643. FDH_alpha. 1 hit.
SMARTi SM00926. Molybdop_Fe4S4. 1 hit.
SM00929. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view ]
SUPFAMi SSF50692. SSF50692. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsi TIGR01591. Fdh-alpha. 1 hit.
PROSITEi PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species."
    Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K.
    J. Bacteriol. 187:7292-7308(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCSC1435.

Entry informationi

Entry nameiFDHL_STAHJ
AccessioniPrimary (citable) accession number: Q4L8G8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: August 2, 2005
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3