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Q4L8G8

- FDHL_STAHJ

UniProt

Q4L8G8 - FDHL_STAHJ

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Protein
Putative formate dehydrogenase SH0748
Gene
SH0748
Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Formate + NAD+ = CO2 + NADH.

Cofactori

Binds 1 2Fe-2S cluster By similarity.
Binds 4 4Fe-4S clusters By similarity.
Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi37 – 371Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi48 – 481Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi51 – 511Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi63 – 631Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi95 – 951Iron-sulfur 2 (4Fe-4S); via tele nitrogen By similarity
Metal bindingi99 – 991Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi102 – 1021Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi109 – 1091Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi147 – 1471Iron-sulfur 3 (4Fe-4S) By similarity
Metal bindingi150 – 1501Iron-sulfur 3 (4Fe-4S) By similarity
Metal bindingi153 – 1531Iron-sulfur 3 (4Fe-4S) By similarity
Metal bindingi157 – 1571Iron-sulfur 4 (4Fe-4S) By similarity
Metal bindingi190 – 1901Iron-sulfur 4 (4Fe-4S) By similarity
Metal bindingi193 – 1931Iron-sulfur 4 (4Fe-4S) By similarity
Metal bindingi196 – 1961Iron-sulfur 4 (4Fe-4S) By similarity
Metal bindingi200 – 2001Iron-sulfur 3 (4Fe-4S) By similarity
Metal bindingi264 – 2641Iron-sulfur 5 (4Fe-4S) By similarity
Metal bindingi267 – 2671Iron-sulfur 5 (4Fe-4S) By similarity
Metal bindingi271 – 2711Iron-sulfur 5 (4Fe-4S) By similarity
Metal bindingi299 – 2991Iron-sulfur 5 (4Fe-4S) By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  3. electron carrier activity Source: InterPro
  4. formate dehydrogenase (NAD+) activity Source: UniProtKB-EC
  5. molybdenum ion binding Source: InterPro

GO - Biological processi

  1. formate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD

Enzyme and pathway databases

BioCyciSHAE279808:GJX7-750-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative formate dehydrogenase SH0748 (EC:1.2.1.2)
Gene namesi
Ordered Locus Names:SH0748
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000543: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 984984Putative formate dehydrogenase SH0748
PRO_0000304136Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279808.SH0748.

Structurei

3D structure databases

ProteinModelPortaliQ4L8G8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 79772Fe-2S ferredoxin-type
Add
BLAST
Domaini138 – 165284Fe-4S ferredoxin-type 1
Add
BLAST
Domaini181 – 211314Fe-4S ferredoxin-type 2
Add
BLAST
Domaini257 – 313574Fe-4S Mo/W bis-MGD-type
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni252 – 984733Formate dehydrogenase
Add
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG3383.
HOGENOMiHOG000031440.
KOiK00123.
OMAiMHIDAFV.
OrthoDBiEOG6CVV7G.

Family and domain databases

InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR001450. 4Fe4S-bd_dom.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR009010. Asp_de-COase-like_dom.
IPR006478. Formate_DH_asu.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR006655. Mopterin_OxRdtase_prok_CS.
IPR027467. MopterinOxRdtase_cofactor_BS.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
[Graphical view]
PfamiPF12838. Fer4_7. 1 hit.
PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
PIRSFiPIRSF036643. FDH_alpha. 1 hit.
SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
SM00929. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR01591. Fdh-alpha. 1 hit.
PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4L8G8-1 [UniParc]FASTAAdd to Basket

« Hide

MQEHLIVTLD GTDYLVEPGT SLLEFIKSRD TFVPSICYNE SMGPIQTCDT    50
CMVEIDGKIE RACSTVVNRP MTVNTQNNDV KASQKEALDR ILEKHMLYCT 100
VCDYNNGDCE IHNAMDAWGL EEQSYEYKTK PYEKDYGPFY RYDPDQCILC 150
GRCVEACQDI EVNETISIDW NREHPRVIWD NDVPINESSC VSCGQCATVC 200
PCNAMMEVNM EGNAGYMTDT EPGSLAAMID LTKKAEPGDG LLFAVSDSEA 250
EMRKERIKKT KTVCTYCGVG CSFDVWTKDR EVLKVQPSHD SPANKIATCV 300
KGKFSWGHIN SDQRLTKPLV RKDGEFHEVE WDEALDVIET NFKRIKNEYG 350
GDHLAFIASS KGTNEESYLM QKLSRQVFGS NNVDNCSRYC QAPATKGLFR 400
TVGHGGDSGS IEDLERAAMT VLIGTNTAEA HPVIASRMKR AQKLFGQKMH 450
VFDIRKHEMA ARADAFYQPK PGTDLVWLGA ATKYIIDNDL HDKAFLNDWV 500
DNYEDYYKSL ELFTMDFAEE TTGIPKEQII SFAEEAAKAE SMSICWAMGV 550
TQQDIGSDTS TAISNLLLVT GNYRKPGSGA YPLRGHNNVQ GASDMGSMPD 600
QFPGYQKVAD DEVRAKFEKE YGVELNPTPG RDNHQMMEGI HNGDIQSLYL 650
YGEDTGIVDS NINFVQSALE KVDFLVVQDE FLTFTATYAD VVLPASPSLE 700
KDGTFTNTER RIQRINKALQ PLGDSKPDWE IFQLIAQRMG ADWNYKHPSE 750
IMDEIAGLTP SYSGVNYERL QGFNSLQWPV APDGTDQPTL YMDGFNFENG 800
RAKLFPLTFD NFFKEDEVYD LHVNNGRLLE HFHEGNMTYQ TEMIKYKVPN 850
AFVEISPELA KDRDIHEGAE LRLISETGEA TLIATVTDRV KGREIYIPLN 900
NDAMSNGDLG AINKLTNSDV DKYTDTPSYK RTSCRMEVLT RKGKSPLNPT 950
NFRVDKQRNP QYSVQVQKKW ERPDYVFPGN VVDK 984
Length:984
Mass (Da):110,941
Last modified:August 2, 2005 - v1
Checksum:iF0CCF0467C86D89F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006716 Genomic DNA. Translation: BAE04057.1.
RefSeqiWP_011275072.1. NC_007168.1.
YP_252663.1. NC_007168.1.

Genome annotation databases

EnsemblBacteriaiBAE04057; BAE04057; SH0748.
GeneIDi3483766.
KEGGisha:SH0748.
PATRICi19617516. VBIStaHae67511_0734.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006716 Genomic DNA. Translation: BAE04057.1 .
RefSeqi WP_011275072.1. NC_007168.1.
YP_252663.1. NC_007168.1.

3D structure databases

ProteinModelPortali Q4L8G8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 279808.SH0748.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE04057 ; BAE04057 ; SH0748 .
GeneIDi 3483766.
KEGGi sha:SH0748.
PATRICi 19617516. VBIStaHae67511_0734.

Phylogenomic databases

eggNOGi COG3383.
HOGENOMi HOG000031440.
KOi K00123.
OMAi MHIDAFV.
OrthoDBi EOG6CVV7G.

Enzyme and pathway databases

BioCyci SHAE279808:GJX7-750-MONOMER.

Family and domain databases

InterProi IPR001041. 2Fe-2S_ferredoxin-type.
IPR001450. 4Fe4S-bd_dom.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR009010. Asp_de-COase-like_dom.
IPR006478. Formate_DH_asu.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR006655. Mopterin_OxRdtase_prok_CS.
IPR027467. MopterinOxRdtase_cofactor_BS.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
[Graphical view ]
Pfami PF12838. Fer4_7. 1 hit.
PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF036643. FDH_alpha. 1 hit.
SMARTi SM00926. Molybdop_Fe4S4. 1 hit.
SM00929. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view ]
SUPFAMi SSF50692. SSF50692. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsi TIGR01591. Fdh-alpha. 1 hit.
PROSITEi PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species."
    Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K.
    J. Bacteriol. 187:7292-7308(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCSC1435.

Entry informationi

Entry nameiFDHL_STAHJ
AccessioniPrimary (citable) accession number: Q4L8G8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: August 2, 2005
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi