Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative formate dehydrogenase SH0748

Gene

SH0748

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Formate + NAD+ = CO2 + NADH.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi37Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi48Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi51Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi63Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi95Iron-sulfur 2 (4Fe-4S); via tele nitrogenPROSITE-ProRule annotation1
Metal bindingi99Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi102Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi109Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi147Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi150Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi153Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi157Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi190Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi193Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi196Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi200Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi264Iron-sulfur 5 (4Fe-4S)By similarity1
Metal bindingi267Iron-sulfur 5 (4Fe-4S)By similarity1
Metal bindingi271Iron-sulfur 5 (4Fe-4S)By similarity1
Metal bindingi299Iron-sulfur 5 (4Fe-4S)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Ligand2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Putative formate dehydrogenase SH0748 (EC:1.17.1.9)
Gene namesi
Ordered Locus Names:SH0748
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000543 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003041361 – 984Putative formate dehydrogenase SH0748Add BLAST984

Interactioni

Protein-protein interaction databases

STRINGi279808.SH0748

Structurei

3D structure databases

ProteinModelPortaliQ4L8G8
SMRiQ4L8G8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 792Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST77
Domaini79 – 1194Fe-4S His(Cys)3-ligated-typePROSITE-ProRule annotationAdd BLAST41
Domaini138 – 1654Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST28
Domaini181 – 2114Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST31
Domaini257 – 3134Fe-4S Mo/W bis-MGD-typePROSITE-ProRule annotationAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni252 – 984Formate dehydrogenaseAdd BLAST733

Sequence similaritiesi

In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108JB9 Bacteria
COG3383 LUCA
HOGENOMiHOG000031440
KOiK00123
OMAiTNTAECH
OrthoDBiPOG091H037M

Family and domain databases

CDDicd00207 fer2, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR009010 Asp_de-COase-like_dom_sf
IPR006478 Formate_DH_asu
IPR006657 MoPterin_dinucl-bd_dom
IPR006656 Mopterin_OxRdtase
IPR006963 Mopterin_OxRdtase_4Fe-4S_dom
IPR006655 Mopterin_OxRdtase_prok_CS
IPR027467 MopterinOxRdtase_cofactor_BS
IPR019574 NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd
PfamiView protein in Pfam
PF12838 Fer4_7, 1 hit
PF04879 Molybdop_Fe4S4, 1 hit
PF00384 Molybdopterin, 1 hit
PF01568 Molydop_binding, 1 hit
PF10588 NADH-G_4Fe-4S_3, 1 hit
SMARTiView protein in SMART
SM00926 Molybdop_Fe4S4, 1 hit
SM00929 NADH-G_4Fe-4S_3, 1 hit
SUPFAMiSSF50692 SSF50692, 1 hit
SSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR01591 Fdh-alpha, 1 hit
PROSITEiView protein in PROSITE
PS51085 2FE2S_FER_2, 1 hit
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 2 hits
PS51839 4FE4S_HC3, 1 hit
PS51669 4FE4S_MOW_BIS_MGD, 1 hit
PS00551 MOLYBDOPTERIN_PROK_1, 1 hit
PS00932 MOLYBDOPTERIN_PROK_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q4L8G8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEHLIVTLD GTDYLVEPGT SLLEFIKSRD TFVPSICYNE SMGPIQTCDT
60 70 80 90 100
CMVEIDGKIE RACSTVVNRP MTVNTQNNDV KASQKEALDR ILEKHMLYCT
110 120 130 140 150
VCDYNNGDCE IHNAMDAWGL EEQSYEYKTK PYEKDYGPFY RYDPDQCILC
160 170 180 190 200
GRCVEACQDI EVNETISIDW NREHPRVIWD NDVPINESSC VSCGQCATVC
210 220 230 240 250
PCNAMMEVNM EGNAGYMTDT EPGSLAAMID LTKKAEPGDG LLFAVSDSEA
260 270 280 290 300
EMRKERIKKT KTVCTYCGVG CSFDVWTKDR EVLKVQPSHD SPANKIATCV
310 320 330 340 350
KGKFSWGHIN SDQRLTKPLV RKDGEFHEVE WDEALDVIET NFKRIKNEYG
360 370 380 390 400
GDHLAFIASS KGTNEESYLM QKLSRQVFGS NNVDNCSRYC QAPATKGLFR
410 420 430 440 450
TVGHGGDSGS IEDLERAAMT VLIGTNTAEA HPVIASRMKR AQKLFGQKMH
460 470 480 490 500
VFDIRKHEMA ARADAFYQPK PGTDLVWLGA ATKYIIDNDL HDKAFLNDWV
510 520 530 540 550
DNYEDYYKSL ELFTMDFAEE TTGIPKEQII SFAEEAAKAE SMSICWAMGV
560 570 580 590 600
TQQDIGSDTS TAISNLLLVT GNYRKPGSGA YPLRGHNNVQ GASDMGSMPD
610 620 630 640 650
QFPGYQKVAD DEVRAKFEKE YGVELNPTPG RDNHQMMEGI HNGDIQSLYL
660 670 680 690 700
YGEDTGIVDS NINFVQSALE KVDFLVVQDE FLTFTATYAD VVLPASPSLE
710 720 730 740 750
KDGTFTNTER RIQRINKALQ PLGDSKPDWE IFQLIAQRMG ADWNYKHPSE
760 770 780 790 800
IMDEIAGLTP SYSGVNYERL QGFNSLQWPV APDGTDQPTL YMDGFNFENG
810 820 830 840 850
RAKLFPLTFD NFFKEDEVYD LHVNNGRLLE HFHEGNMTYQ TEMIKYKVPN
860 870 880 890 900
AFVEISPELA KDRDIHEGAE LRLISETGEA TLIATVTDRV KGREIYIPLN
910 920 930 940 950
NDAMSNGDLG AINKLTNSDV DKYTDTPSYK RTSCRMEVLT RKGKSPLNPT
960 970 980
NFRVDKQRNP QYSVQVQKKW ERPDYVFPGN VVDK
Length:984
Mass (Da):110,941
Last modified:August 2, 2005 - v1
Checksum:iF0CCF0467C86D89F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA Translation: BAE04057.1
RefSeqiWP_011275072.1, NC_007168.1

Genome annotation databases

EnsemblBacteriaiBAE04057; BAE04057; SH0748
GeneIDi24248206
KEGGisha:SH0748

Similar proteinsi

Entry informationi

Entry nameiFDHL_STAHJ
AccessioniPrimary (citable) accession number: Q4L8G8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: August 2, 2005
Last modified: April 25, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome