Reviewed, UniProtKB/Swiss-Prot Q4L871 (LACD_STAHJ)

Names and origin

Protein names

Recommended name:
    Tagatose 1,6-diphosphate aldolase
    EC=4.1.2.40
Alternative name(s):
    Tagatose-bisphosphate aldolase
    D-tagatose-1,6-bisphosphate aldolase

Gene names

Name:	lacD
Ordered Locus Names:	SH0845

Organism

Staphylococcus haemolyticus (strain JCSC1435) [Complete proteome] [HAMAP]

Taxonomic identifier

279808 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-tagatose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. HAMAP MF_00734
Pathway	Carbohydrate metabolism; D-tagatose 6-phosphate degradation; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 2/2. HAMAP MF_00734
Sequence similarities	Belongs to the aldolase lacD family.

Ontologies

Keywords
Biological process	Lactose metabolism
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lactose catabolic process via tagatose-6-phosphate Inferred from electronic annotation. Source: HAMAP
Molecular function	tagatose-6-phosphate kinase activity Inferred from electronic annotation. Source: InterPro tagatose-bisphosphate aldolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 325	325	Tagatose 1,6-diphosphate aldolase HAMAP MF_00734		PRO_0000203953

Sequences

	Sequence		Length	Mass (Da)
	Q4L871-1 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: DCE841BB6C1256D3	FASTA	325	36,569
	10 20 30 40 50 60 MTKSQQKLAS IEQLSNQDGI ISALAFDQRG ALKRMMAEHQ TEPPTVEQIE QLKVLVSEEL 70 80 90 100 110 120 TQYASSILLD PEYGLPASDA RNKECGLLLA YEKTGYDVNA KGRLPDCLVE WSAKRLKEQG 130 140 150 160 170 180 ANAVKFLLYY DVDDSEEINI QKKAYIERIG SECVAEDIPF FLEVLTYDDN IPDNKSAEFA 190 200 210 220 230 240 KVKPRKVNEA MKLFSEDRFN VDVLKVEVPV NMNFVEGFTE GEVVYTKEEA AQHFRDQEAA 250 260 270 280 290 300 THLPYIYLSA GVSAELFQET LTFAHDAGAH FNGVLCGRAT WSGAVKVYIE QGEQAAREWL 310 320 RTTGYKNIDD LNKVLKTTAT SWKAK

References

[1]

"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species." Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K. J. Bacteriol. 187:7292-7308(2005) [PubMed: 16237012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP006716 Genomic DNA. Translation: BAE04154.1.
RefSeq	YP_252760.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3482143.
GenomeReviews	Gene locus SH0845 in contig AP006716_GR.
KEGG	sha:SH0845.
NMPDR	fig|279808.3.peg.858.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4L871.
OMA	Q4L871. SEELTQY.
Enzyme and pathway databases
BioCyc	SHAE279808:SH0845-MON.
Family and domain databases
HAMAP	MF_00734. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR002915. DeoC/AroFGH_arch. IPR005927. LacD_Gpos. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
TIGRFAMs	TIGR01232. lacD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LACD_STAHJ

Accession

Primary (citable) accession number: Q4L871

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	August 2, 2005
Last modified:	June 16, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)