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Q4L868

- LACG_STAHJ

UniProt

Q4L868 - LACG_STAHJ

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Protein

6-phospho-beta-galactosidase

Gene
lacG, SH0848
Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

A 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei159 – 1591Proton donor By similarity
Active sitei374 – 3741Nucleophile By similarity

GO - Molecular functioni

  1. 6-phospho-beta-galactosidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lactose catabolic process via tagatose-6-phosphate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciSHAE279808:GJX7-850-MONOMER.
UniPathwayiUPA00542; UER00605.

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phospho-beta-galactosidase (EC:3.2.1.85)
Alternative name(s):
Beta-D-phosphogalactoside galactohydrolase
Short name:
PGALase
P-beta-Gal
Short name:
PBG
Gene namesi
Name:lacG
Ordered Locus Names:SH0848
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000543: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4694696-phospho-beta-galactosidaseUniRule annotationPRO_0000260727Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279808.SH0848.

Structurei

3D structure databases

ProteinModelPortaliQ4L868.
SMRiQ4L868. Positions 2-469.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2723.
HOGENOMiHOG000088632.
KOiK01220.
OMAiNRWYLDP.
OrthoDBiEOG60658J.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
HAMAPiMF_01574. LacG.
InterProiIPR005928. 6P-beta-galactosidase.
IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
TIGRFAMsiTIGR01233. lacG. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4L868-1 [UniParc]FASTAAdd to Basket

« Hide

MKKLPEDFIF GGATAAYQAE GATQTDGKGR VAWDTYLEEN YWYTAEPASD    50
FYNKYPIDLE LSEKFGVNGI RISIAWSRIF PKGYGEVNPK GVEYYHNLFK 100
ECHRRHVEPF VTLHHFDTPE TLHSDGDFLN RKTIEYFVEY AKFCFEEFEE 150
VNYWTTFNEI GPIGDGQYLV GKFPPGIKYD FAKVFQSHHN MMVAHAKAVK 200
LFKDNGYSGE VGVVHALPTK YPYDPTNPED VRAAELEDII HNKFILDATY 250
LGKYSRETME GVQHILSVNG GKLDIPEEDY KVLEAAKDLN DFLGINYYMS 300
DWMRGYDGES EITHNATGDK GGSKYQLKGV GQREFDVDVP RTDWDWMIYP 350
KGLYDQIMRV VKDYPNYHKI YITENGLGYK DQFDEERKTV DDDARIDYVK 400
KHLEVISDAI RDGANVKGYF IWSLMDVFSW SNGYEKRYGL FYVDFETQER 450
YPKKSAYWYK ELAESKEIK 469
Length:469
Mass (Da):54,646
Last modified:August 2, 2005 - v1
Checksum:i0D933E94BF925793
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006716 Genomic DNA. Translation: BAE04157.1.
RefSeqiYP_252763.1. NC_007168.1.

Genome annotation databases

EnsemblBacteriaiBAE04157; BAE04157; SH0848.
GeneIDi3482146.
KEGGisha:SH0848.
PATRICi19617714. VBIStaHae67511_0833.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006716 Genomic DNA. Translation: BAE04157.1 .
RefSeqi YP_252763.1. NC_007168.1.

3D structure databases

ProteinModelPortali Q4L868.
SMRi Q4L868. Positions 2-469.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 279808.SH0848.

Protein family/group databases

CAZyi GH1. Glycoside Hydrolase Family 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE04157 ; BAE04157 ; SH0848 .
GeneIDi 3482146.
KEGGi sha:SH0848.
PATRICi 19617714. VBIStaHae67511_0833.

Phylogenomic databases

eggNOGi COG2723.
HOGENOMi HOG000088632.
KOi K01220.
OMAi NRWYLDP.
OrthoDBi EOG60658J.

Enzyme and pathway databases

UniPathwayi UPA00542 ; UER00605 .
BioCyci SHAE279808:GJX7-850-MONOMER.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
HAMAPi MF_01574. LacG.
InterProi IPR005928. 6P-beta-galactosidase.
IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10353. PTHR10353. 1 hit.
Pfami PF00232. Glyco_hydro_1. 1 hit.
[Graphical view ]
PRINTSi PR00131. GLHYDRLASE1.
SUPFAMi SSF51445. SSF51445. 1 hit.
TIGRFAMsi TIGR01233. lacG. 1 hit.
PROSITEi PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species."
    Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K.
    J. Bacteriol. 187:7292-7308(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCSC1435.

Entry informationi

Entry nameiLACG_STAHJ
AccessioniPrimary (citable) accession number: Q4L868
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: August 2, 2005
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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