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Q4L868 (LACG_STAHJ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
6-phospho-beta-galactosidase

EC=3.2.1.85
Alternative name(s):
Beta-D-phosphogalactoside galactohydrolase
Short name=PGALase
P-beta-Gal
Short name=PBG
Gene names
Name:lacG
Ordered Locus Names:SH0848
OrganismStaphylococcus haemolyticus (strain JCSC1435) [Complete proteome] [HAMAP]
Taxonomic identifier279808 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length469 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

A 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol. HAMAP-Rule MF_01574

Pathway

Carbohydrate metabolism; lactose degradation; D-galactose 6-phosphate and beta-D-glucose from lactose 6-phosphate: step 1/1. HAMAP-Rule MF_01574

Sequence similarities

Belongs to the glycosyl hydrolase 1 family.

Ontologies

Keywords
   Molecular functionGlycosidase
Hydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlactose catabolic process via tagatose-6-phosphate

Inferred from electronic annotation. Source: InterPro

   Molecular_function6-phospho-beta-galactosidase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4694696-phospho-beta-galactosidase HAMAP-Rule MF_01574
PRO_0000260727

Sites

Active site1591Proton donor By similarity
Active site3741Nucleophile By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4L868 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: 0D933E94BF925793

FASTA46954,646
        10         20         30         40         50         60 
MKKLPEDFIF GGATAAYQAE GATQTDGKGR VAWDTYLEEN YWYTAEPASD FYNKYPIDLE 

        70         80         90        100        110        120 
LSEKFGVNGI RISIAWSRIF PKGYGEVNPK GVEYYHNLFK ECHRRHVEPF VTLHHFDTPE 

       130        140        150        160        170        180 
TLHSDGDFLN RKTIEYFVEY AKFCFEEFEE VNYWTTFNEI GPIGDGQYLV GKFPPGIKYD 

       190        200        210        220        230        240 
FAKVFQSHHN MMVAHAKAVK LFKDNGYSGE VGVVHALPTK YPYDPTNPED VRAAELEDII 

       250        260        270        280        290        300 
HNKFILDATY LGKYSRETME GVQHILSVNG GKLDIPEEDY KVLEAAKDLN DFLGINYYMS 

       310        320        330        340        350        360 
DWMRGYDGES EITHNATGDK GGSKYQLKGV GQREFDVDVP RTDWDWMIYP KGLYDQIMRV 

       370        380        390        400        410        420 
VKDYPNYHKI YITENGLGYK DQFDEERKTV DDDARIDYVK KHLEVISDAI RDGANVKGYF 

       430        440        450        460 
IWSLMDVFSW SNGYEKRYGL FYVDFETQER YPKKSAYWYK ELAESKEIK 

« Hide

References

[1]"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species."
Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K.
J. Bacteriol. 187:7292-7308(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JCSC1435.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP006716 Genomic DNA. Translation: BAE04157.1.
RefSeqYP_252763.1. NC_007168.1.

3D structure databases

ProteinModelPortalQ4L868.
SMRQ4L868. Positions 2-469.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING279808.SH0848.

Protein family/group databases

CAZyGH1. Glycoside Hydrolase Family 1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAE04157; BAE04157; SH0848.
GeneID3482146.
KEGGsha:SH0848.
PATRIC19617714. VBIStaHae67511_0833.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2723.
HOGENOMHOG000088632.
KOK01220.
OMANRWYLDP.
OrthoDBEOG60658J.

Enzyme and pathway databases

BioCycSHAE279808:GJX7-850-MONOMER.
UniPathwayUPA00542; UER00605.

Family and domain databases

Gene3D3.20.20.80. 1 hit.
HAMAPMF_01574. LacG.
InterProIPR005928. 6P-beta-galactosidase.
IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR10353. PTHR10353. 1 hit.
PfamPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSPR00131. GLHYDRLASE1.
SUPFAMSSF51445. SSF51445. 1 hit.
TIGRFAMsTIGR01233. lacG. 1 hit.
PROSITEPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLACG_STAHJ
AccessionPrimary (citable) accession number: Q4L868
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: August 2, 2005
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries