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Protein

Heme oxygenase (staphylobilin-producing)

Gene

isdG

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.UniRule annotation

Catalytic activityi

Protoheme + 5 reduced acceptor + 4 O2 = 5-oxo-delta-bilirubin + Fe2+ + formaldehyde + 5 acceptor + 4 H2O.UniRule annotation
Protoheme + 5 reduced acceptor + 4 O2 = 15-oxo-beta-bilirubin + Fe2+ + formaldehyde + 5 acceptor + 4 H2O.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi6IronUniRule annotation1
Sitei66Transition state stabilizerUniRule annotation1
Metal bindingi76Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heme oxygenase (staphylobilin-producing)UniRule annotation (EC:1.14.99.48UniRule annotation)
Alternative name(s):
Heme-degrading monooxygenaseUniRule annotation
Iron-regulated surface determinantUniRule annotation
Iron-responsive surface determinantUniRule annotation
Gene namesi
Name:isdG
Ordered Locus Names:SH0867
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000543 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002700991 – 104Heme oxygenase (staphylobilin-producing)Add BLAST104

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi279808.SH0867

Structurei

3D structure databases

ProteinModelPortaliQ4L849
SMRiQ4L849
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 94ABMUniRule annotationAdd BLAST93

Sequence similaritiesi

Belongs to the antibiotic biosynthesis monooxygenase family. Heme-degrading monooxygenase IsdG subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106EQQ Bacteria
COG2329 LUCA
HOGENOMiHOG000008026
KOiK07145
OMAiFEAWRNS
OrthoDBiPOG091H054M

Family and domain databases

HAMAPiMF_01272 Heme_degrading_monooxygenase, 1 hit
InterProiView protein in InterPro
IPR007138 ABM_dom
IPR011008 Dimeric_a/b-barrel
IPR023953 IsdG
PfamiView protein in Pfam
PF03992 ABM, 1 hit
SUPFAMiSSF54909 SSF54909, 1 hit
PROSITEiView protein in PROSITE
PS51725 ABM, 1 hit

Sequencei

Sequence statusi: Complete.

Q4L849-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFVVTNRITV KKGFAEKMAP RFTKGGKIEA LQGFHKIEVW KVTRDHENED
60 70 80 90 100
MYVNTWWETE KDFEAWTKSD AFKEAHQNRD KTSSESSPVI SSEIVKATVL

STLN
Length:104
Mass (Da):12,025
Last modified:August 2, 2005 - v1
Checksum:i9BF949E5DAE814A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA Translation: BAE04176.1
RefSeqiWP_011275179.1, NC_007168.1

Genome annotation databases

EnsemblBacteriaiBAE04176; BAE04176; SH0867
GeneIDi24247434
KEGGisha:SH0867

Similar proteinsi

Entry informationi

Entry nameiHDOX_STAHJ
AccessioniPrimary (citable) accession number: Q4L849
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: August 2, 2005
Last modified: April 25, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health