Q4L818 (PDP_STAHJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyrimidine-nucleoside phosphorylase
Short name=PYNP
EC=2.4.2.2

Gene names

Name:	pdp
Synonyms:	pyn
Ordered Locus Names:	SH0898

Organism

Staphylococcus haemolyticus (strain JCSC1435) [Complete proteome] [HAMAP]

Taxonomic identifier

279808 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus haemolyticus

Protein attributes

Sequence length	433 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	A pyrimidine nucleoside + phosphate = a pyrimidine base + alpha-D-ribose 1-phosphate.
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pyrimidine nucleobase metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleoside metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	phosphorylase activity Inferred from electronic annotation. Source: InterPro pyrimidine-nucleoside phosphorylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 433	433	Pyrimidine-nucleoside phosphorylase		PRO_0000269541

Sequences

	Sequence		Length	Mass (Da)
	Q4L818 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 84A8194A7124C80C	FASTA	433	46,177
	10 20 30 40 50 60 MRMVDIIEKK RDGKSLSKEE IEFFIKGYTN GDIPDYQASS LAMAIFFQDM NDEERAALTM 70 80 90 100 110 120 AMVNSGDVID LSKINGIKVD KHSTGGVGDT TTLVLAPLVA AVGVPVAKMS GRGLGHTGGT 130 140 150 160 170 180 IDKLESIKGF HVEISEEDFI KLVNENQVAV IGQSGNLTPA DKKLYALRDV TGTVNSIPLI 190 200 210 220 230 240 ASSIMSKKIA AGADAIVLDV KTGNGAFMKT LEDAEALAHA MVSIGNNVGR NTMAIISDMS 250 260 270 280 290 300 QPLGRAIGNA LELKEAIDTL NGKGPEDLTE LVLTLGSQMV VLANRANTLE EARQLLNEAI 310 320 330 340 350 360 ENGSALEKFK TFLENQGGDV SVVDAPELLP TATYQIEYKA QSSGVVSELI ANEIGVASMM 370 380 390 400 410 420 LGAGRQTKED EIDLSVGIVL NKKVGDVVKE GESLLTIHSN RENVDDVIKK LDESIEIQAQ 430 ATTPTLIHKI ITE

References

[1]

"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species." Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K. J. Bacteriol. 187:7292-7308(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JCSC1435.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006716 Genomic DNA. Translation: BAE04207.1.
RefSeq	YP_252813.1. NC_007168.1.
3D structure databases
ProteinModelPortal	Q4L818.
SMR	Q4L818. Positions 1-431.
ModBase	Search...
Protein-protein interaction databases
STRING	279808.SH0898.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAE04207; BAE04207; SH0898.
GeneID	3482297.
KEGG	sha:SH0898.
PATRIC	19617837. VBIStaHae67511_0885.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0213.
HOGENOM	HOG000047312.
KO	K00756.
OMA	LMAIYFR.
ProtClustDB	PRK06078.
Enzyme and pathway databases
BioCyc	SHAE279808:GJX7-909-MONOMER.
Family and domain databases
Gene3D	3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit.
InterPro	IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR013102. PYNP_C. IPR018090. Pyrmidine_PPas_bac/euk. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. [Graphical view]
PANTHER	PTHR10515. PTHR10515. 1 hit.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
PIRSF	PIRSF000478. TP_PyNP. 1 hit.
SMART	SM00941. PYNP_C. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit. SSF54680. PYNP_C. 1 hit.
TIGRFAMs	TIGR02644. Y_phosphoryl. 1 hit.
PROSITE	PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PDP_STAHJ

Accession

Primary (citable) accession number: Q4L818

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	August 2, 2005
Last modified:	May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program