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Protein

Putative aldehyde dehydrogenase SH0913

Gene

SH0913

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei245 – 2451By similarity
Active sitei279 – 2791By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi201 – 2077NADBy similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSHAE279808:GJX7-924-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative aldehyde dehydrogenase SH0913 (EC:1.2.1.3)
Gene namesi
Ordered Locus Names:SH0913
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000543 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475Putative aldehyde dehydrogenase SH0913PRO_0000293563Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279808.SH0913.

Structurei

3D structure databases

ProteinModelPortaliQ4L803.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00128.
OMAiSGMVEMN.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4L803-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNYTQQYIN GEWIDSDSNE TIEVINPATE EVIGKVAKGN SNDVEKAVEA
60 70 80 90 100
ANNVYLEFRH SSVKERKELL DKIVEEYKNR KQDIIEAITD ELGAPLTLSE
110 120 130 140 150
NVHYQMGLNH FEEASRALDS FEFEERRGDA LVTKEAIGVS GLVTPWNFPT
160 170 180 190 200
NQTSLKLAAA FAAGSPVVLK PSEETPFAAV ILAEIFDKVG VPKGVFNLVN
210 220 230 240 250
GDGEGVGNPL SEHPKVRMMS FTGSGRTGSK IMEKASKDFK KVSLELGGKS
260 270 280 290 300
PYIVLDDVDV KEAAKATTGK VVNNTGQVCT AGTRILIPES KKEDFLTALK
310 320 330 340 350
EEFSKVKVGD PREEGTQVGP IISKKQFDTV QSYIDKGIEE GAELFYGGPG
360 370 380 390 400
KPEGLNTGYF ARPTIFINVD NDMTIAQEEI FGPVASVITY NNLDEAIKIA
410 420 430 440 450
NDTKYGLAGY VIGKDKETLQ KVARSIEAGR IEINEAGNQP DLPFGGYKQS
460 470
GIGREWGDYG IEEFLEVKSI AGYFS
Length:475
Mass (Da):51,949
Last modified:July 10, 2007 - v2
Checksum:i8B75A796F9CDCCE7
GO

Sequence cautioni

The sequence BAE04222.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA. Translation: BAE04222.1. Different initiation.
RefSeqiWP_011275224.1. NC_007168.1.
YP_252828.1. NC_007168.1.

Genome annotation databases

EnsemblBacteriaiBAE04222; BAE04222; SH0913.
KEGGisha:SH0913.
PATRICi19617867. VBIStaHae67511_0900.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA. Translation: BAE04222.1. Different initiation.
RefSeqiWP_011275224.1. NC_007168.1.
YP_252828.1. NC_007168.1.

3D structure databases

ProteinModelPortaliQ4L803.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi279808.SH0913.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAE04222; BAE04222; SH0913.
KEGGisha:SH0913.
PATRICi19617867. VBIStaHae67511_0900.

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00128.
OMAiSGMVEMN.
OrthoDBiEOG6BS8QW.

Enzyme and pathway databases

BioCyciSHAE279808:GJX7-924-MONOMER.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species."
    Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K.
    J. Bacteriol. 187:7292-7308(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCSC1435.

Entry informationi

Entry nameiALD1_STAHJ
AccessioniPrimary (citable) accession number: Q4L803
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: April 29, 2015
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.