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Protein

Probable manganese-dependent inorganic pyrophosphatase

Gene

ppaC

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9Manganese 1UniRule annotation1
Metal bindingi13Manganese 1UniRule annotation1
Metal bindingi15Manganese 2UniRule annotation1
Metal bindingi75Manganese 1UniRule annotation1
Metal bindingi75Manganese 2UniRule annotation1
Metal bindingi97Manganese 2UniRule annotation1
Metal bindingi149Manganese 2UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciSHAE279808:G1G27-994-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable manganese-dependent inorganic pyrophosphataseUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Pyrophosphate phospho-hydrolaseUniRule annotation
Short name:
PPaseUniRule annotation
Gene namesi
Name:ppaCUniRule annotation
Ordered Locus Names:SH1034
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000543 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000123221 – 309Probable manganese-dependent inorganic pyrophosphataseAdd BLAST309

Interactioni

Protein-protein interaction databases

STRINGi279808.SH1034

Structurei

3D structure databases

ProteinModelPortaliQ4L7N2
SMRiQ4L7N2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase class C family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E2M Bacteria
COG1227 LUCA
HOGENOMiHOG000223999
KOiK15986
OMAiSTPLECW
OrthoDBiPOG091H00ML

Family and domain databases

Gene3Di3.10.310.20, 1 hit
HAMAPiMF_00207 PPase_C, 1 hit
InterProiView protein in InterPro
IPR001667 DDH_dom
IPR038763 DHH_sf
IPR004097 DHHA2
IPR038222 DHHA2_dom_sf
IPR022934 Mn-dep_inorganic_PyrPase
PfamiView protein in Pfam
PF01368 DHH, 1 hit
PF02833 DHHA2, 1 hit
SMARTiView protein in SMART
SM01131 DHHA2, 1 hit
SUPFAMiSSF64182 SSF64182, 1 hit

Sequencei

Sequence statusi: Complete.

Q4L7N2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKTYIFGHQ NPDTDAIASA IIMADFEQLT GNSEATPYRL GDINPETKFA
60 70 80 90 100
LDHFEVKAPE LLSDNLDGRE VILVDHNEFQ QSAETISDAE IKHVVDHHRI
110 120 130 140 150
ANFETASPLW YRAEPVGCTA TILYKMYKER GFEIKPHIAG LMISAIISDS
160 170 180 190 200
LLFKSPTCTD EDVNAAKDLK DLANVDLDEY GLEMLKAGAS TTDKSAEELL
210 220 230 240 250
DMDAKSFNMG DYVTRIAQVN TVDIDEVLNR KEDLEKAMLE TSANEKYDLF
260 270 280 290 300
VLVVTDIINS DSKILVVGAE KDKVGEAFKV QLDDGMAFLS GVVSRKKQVV

PQITDALIK
Length:309
Mass (Da):34,255
Last modified:August 2, 2005 - v1
Checksum:i39E3A78252F52B91
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA Translation: BAE04343.1
RefSeqiWP_011275340.1, NC_007168.1

Genome annotation databases

EnsemblBacteriaiBAE04343; BAE04343; SH1034
GeneIDi24245879
KEGGisha:SH1034

Similar proteinsi

Entry informationi

Entry nameiPPAC_STAHJ
AccessioniPrimary (citable) accession number: Q4L7N2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 2, 2005
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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