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Q4L7L1

- DAGK_STAHJ

UniProt

Q4L7L1 - DAGK_STAHJ

Protein

Diacylglycerol kinase

Gene

dagK

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (02 Aug 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of diacylglycerol (DAG) into phosphatidic acid. Is a key enzyme involved in the production of lipoteichoic acid by reintroducing DAG formed from the breakdown of membrane phospholipids into the phosphatidylglycerol biosynthetic pathway By similarity.By similarity

    Catalytic activityi

    ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

    Cofactori

    Binds 1 magnesium ion per subunit. This ion appears to have a structural role and is required for catalytic activity By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei41 – 411ATPPROSITE-ProRule annotation
    Binding sitei94 – 941ATPPROSITE-ProRule annotation
    Metal bindingi213 – 2131Magnesium; via carbonyl oxygenBy similarity
    Metal bindingi216 – 2161MagnesiumBy similarity
    Metal bindingi218 – 2181Magnesium; via carbonyl oxygenBy similarity
    Active sitei273 – 2731Proton acceptorBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 145ATPPROSITE-ProRule annotation
    Nucleotide bindingi67 – 737ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. diacylglycerol kinase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW
    4. NAD+ kinase activity Source: InterPro

    GO - Biological processi

    1. phospholipid biosynthetic process Source: UniProtKB-KW
    2. protein kinase C-activating G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSHAE279808:GJX7-1071-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diacylglycerol kinase (EC:2.7.1.107)
    Short name:
    DAG kinase
    Short name:
    DAGK
    Gene namesi
    Name:dagK
    Ordered Locus Names:SH1055
    OrganismiStaphylococcus haemolyticus (strain JCSC1435)
    Taxonomic identifieri279808 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000543: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 330330Diacylglycerol kinasePRO_0000386502Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    STRINGi279808.SH1055.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4L7L1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 132132DAGKcPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the diacylglycerol/lipid kinase family.Curated
    Contains 1 DAGKc domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1597.
    HOGENOMiHOG000261395.
    KOiK07029.
    OMAiYLKGMEM.
    OrthoDBiEOG613098.

    Family and domain databases

    Gene3Di3.40.50.10330. 1 hit.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR005218. Diacylglycerol/lipid_kinase.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    [Graphical view]
    PfamiPF00781. DAGK_cat. 1 hit.
    [Graphical view]
    SMARTiSM00046. DAGKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.
    TIGRFAMsiTIGR00147. TIGR00147. 1 hit.
    PROSITEiPS50146. DAGK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4L7L1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKCARIIYN PTSGKELFKR TLPDVLIKLE RAGYETSAYA TEREGDATLE    50
    AERALKRDYD IIIAAGGDGT LNEVVNGIAE QPNRPKLGII PMGTVNDFGR 100
    ALHLPSDIMG AVDVIIDDHT TKVDIGKMNN RYFINLAAGG QLTQVSYETP 150
    SRLKSIVGPF AYYIKGFEML PQMKAVDLRI EYDNQVFQGE ALLFLLGLTN 200
    SMAGFEKLVP DAKLDDGHFT LIIVEKANLA ELGHIMTLAS RGEHIKHPKV 250
    IYEKAKSINI SSFTEMQLNV DGEYGGKLPA NFLNLKRHIE VCTPKDIYNE 300
    ELTEDQQVED GIIEEKPSNE EIIKNNEISE 330
    Length:330
    Mass (Da):36,803
    Last modified:August 2, 2005 - v1
    Checksum:i218DD852D68697D1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006716 Genomic DNA. Translation: BAE04364.1.
    RefSeqiYP_252970.1. NC_007168.1.

    Genome annotation databases

    EnsemblBacteriaiBAE04364; BAE04364; SH1055.
    GeneIDi3483622.
    KEGGisha:SH1055.
    PATRICi19618157. VBIStaHae67511_1040.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006716 Genomic DNA. Translation: BAE04364.1 .
    RefSeqi YP_252970.1. NC_007168.1.

    3D structure databases

    ProteinModelPortali Q4L7L1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 279808.SH1055.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAE04364 ; BAE04364 ; SH1055 .
    GeneIDi 3483622.
    KEGGi sha:SH1055.
    PATRICi 19618157. VBIStaHae67511_1040.

    Phylogenomic databases

    eggNOGi COG1597.
    HOGENOMi HOG000261395.
    KOi K07029.
    OMAi YLKGMEM.
    OrthoDBi EOG613098.

    Enzyme and pathway databases

    BioCyci SHAE279808:GJX7-1071-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.10330. 1 hit.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR005218. Diacylglycerol/lipid_kinase.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    [Graphical view ]
    Pfami PF00781. DAGK_cat. 1 hit.
    [Graphical view ]
    SMARTi SM00046. DAGKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    TIGRFAMsi TIGR00147. TIGR00147. 1 hit.
    PROSITEi PS50146. DAGK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species."
      Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K.
      J. Bacteriol. 187:7292-7308(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JCSC1435.

    Entry informationi

    Entry nameiDAGK_STAHJ
    AccessioniPrimary (citable) accession number: Q4L7L1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 13, 2009
    Last sequence update: August 2, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3