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Protein

Glutamate-1-semialdehyde 2,1-aminomutase 1

Gene

hemL1

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.

Cofactori

pyridoxal 5'-phosphate

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamyl-tRNA reductase (hemA)
  2. Glutamate-1-semialdehyde 2,1-aminomutase 1 (hemL1), Glutamate-1-semialdehyde 2,1-aminomutase 2 (hemL2)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processPorphyrin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase 1 (EC:5.4.3.8)
Short name:
GSA 1
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase 1
Short name:
GSA-AT 1
Gene namesi
Name:hemL1
Ordered Locus Names:SH1097
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000543 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003823831 – 429Glutamate-1-semialdehyde 2,1-aminomutase 1Add BLAST429

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei268N6-(pyridoxal phosphate)lysine1

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi279808.SH1097.

Structurei

3D structure databases

ProteinModelPortaliQ4L7G9.
SMRiQ4L7G9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.

Phylogenomic databases

eggNOGiENOG4105CDM. Bacteria.
COG0001. LUCA.
HOGENOMiHOG000020210.
KOiK01845.
OrthoDBiPOG091H04O1.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_00375. HemL_aminotrans_3. 1 hit.
InterProiView protein in InterPro
IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PfamiView protein in Pfam
PF00202. Aminotran_3. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiView protein in PROSITE
PS00600. AA_TRANSFER_CLASS_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4L7G9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFTESERLQ QLSNEYILGG VNSPSRSYKA VGGGAPVVMR EGHGAYLYDV
60 70 80 90 100
DGNKFIDYLQ AYGPIITGHA HPHITKAIQD QAAKGVLYGT PTELEIEFSK
110 120 130 140 150
KLREAIPSLE KIRFVNSGTE AVMTTIRVAR AYTKRNKIIK FAGSYHGHSD
160 170 180 190 200
LVLVAAGSGP SQLGSPDSAG VPESVAKEVI TVPFNDIESY KEAMKHWGDE
210 220 230 240 250
VAAVLVEPIV GNFGMVEPQP GFLEKVNEIT HDYGALVIYD EVITAFRFHY
260 270 280 290 300
GAAQDLLNVY PDLTAFGKII GGGLPIGGYG GRQDIMEHVA PLGPAYQAGT
310 320 330 340 350
MAGNPLSMRA GIALLEVLEQ NGVYERLDQL GKRLEDGLLE LIDKHNITAT
360 370 380 390 400
INRVYGSLTL YFTDEKITHY EQVENSNGEA FAKFFKLMLN QGINLAPSKF
410 420
EAWFLTTEHT EEDIDETLKA VDYAFSQMK
Length:429
Mass (Da):47,102
Last modified:September 1, 2009 - v2
Checksum:i0F914BB376C4B454
GO

Sequence cautioni

The sequence BAE04406 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA. Translation: BAE04406.1. Different initiation.
RefSeqiWP_011275399.1. NC_007168.1.

Genome annotation databases

EnsemblBacteriaiBAE04406; BAE04406; SH1097.
GeneIDi24247448.
KEGGisha:SH1097.

Similar proteinsi

Entry informationi

Entry nameiGSA1_STAHJ
AccessioniPrimary (citable) accession number: Q4L7G9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: September 1, 2009
Last modified: November 22, 2017
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families