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Q4L7A3

- SYL_STAHJ

UniProt

Q4L7A3 - SYL_STAHJ

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSHAE279808:GJX7-1217-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:SH1163
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000543: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 804804Leucine--tRNA ligasePRO_1000009440Add
BLAST

Proteomic databases

PRIDEiQ4L7A3.

Interactioni

Protein-protein interaction databases

STRINGi279808.SH1163.

Structurei

3D structure databases

ProteinModelPortaliQ4L7A3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionAdd
BLAST
Motifi576 – 5805"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4L7A3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGYNHKEIEK KWQNYWADNK TFKTSDNLGQ KKFYALDMFP YPSGAGLHVG
60 70 80 90 100
HPEGYTATDI VSRYKRMQGY NVLHPMGWDA FGLPAEQYAL DTGNDPREFT
110 120 130 140 150
KQNIQTFKRQ IQELGFSYDW DREVNTTDPE YYKWTQWIFI QLYNKGLAYV
160 170 180 190 200
DEVAVNWCPA LGTVLSNEEV VDGVSERGGH PVYRRPMKQW VLKITEYADR
210 220 230 240 250
LLEDLDELDW PESIKDMQRN WIGRSEGARV SFEIENKDAS IDVFTTRPDT
260 270 280 290 300
IYGTTFLVLS PEHSLVNEIT SEDKLEAVKK YQEDSSKKSD LERTDLAKDK
310 320 330 340 350
SGVFTGAYAI NPLTGKKLPI WIADYVLSSY GTGAVMAVPA HDERDYEFAS
360 370 380 390 400
KFNLPINEVI AGGDIQKEAY TGVGEHINSG ELNGLDNETA ISKAIELLVA
410 420 430 440 450
KGAGEKKVNY KLRDWLFSRQ RYWGEPIPVI HWEDGTMTTV PEEELPLLLP
460 470 480 490 500
ETDEIKPSGT GESPLANIDE FVNVIDEKTG MKGRRETNTM PQWAGSCWYY
510 520 530 540 550
LRYIDPHNSN MLADPEKLKH WLPVDLYIGG VEHAVLHLLY ARFWHKVLYD
560 570 580 590 600
LGVVPTKEPF QKLFNQGMIL GEGNEKMSKS KGNVVNPDDI VDSHGADTLR
610 620 630 640 650
LYEMFMGPLD AAIAWSENGL DGSRRFLDRV WRLFINEDGS LSNKIVENND
660 670 680 690 700
NGLDKVYNQT VKKVTEDFNT LNFNTAISQL MVFINDCYKA ETIYQPYAEG
710 720 730 740 750
FVKMLAPIAP HIGEELWDRL GNEDTITYQP WPTYDESLLV DSEVEIVVQV
760 770 780 790 800
NGKVRAKLNI PKDTSKDEME ALALKDENVK LSIEGKDIKK VIAVPQKLVN

IVAK
Length:804
Mass (Da):91,616
Last modified:August 2, 2005 - v1
Checksum:iCB8F7DB08812C64C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA. Translation: BAE04472.1.
RefSeqiYP_253078.1. NC_007168.1.

Genome annotation databases

EnsemblBacteriaiBAE04472; BAE04472; SH1163.
GeneIDi3482115.
KEGGisha:SH1163.
PATRICi19618445. VBIStaHae67511_1146.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA. Translation: BAE04472.1 .
RefSeqi YP_253078.1. NC_007168.1.

3D structure databases

ProteinModelPortali Q4L7A3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 279808.SH1163.

Proteomic databases

PRIDEi Q4L7A3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE04472 ; BAE04472 ; SH1163 .
GeneIDi 3482115.
KEGGi sha:SH1163.
PATRICi 19618445. VBIStaHae67511_1146.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SHAE279808:GJX7-1217-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species."
    Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K.
    J. Bacteriol. 187:7292-7308(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCSC1435.

Entry informationi

Entry nameiSYL_STAHJ
AccessioniPrimary (citable) accession number: Q4L7A3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 2, 2005
Last modified: November 26, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3