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Q4L776

- FTHS_STAHJ

UniProt

Q4L776 - FTHS_STAHJ

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, SH1190
Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSHAE279808:GJX7-1244-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:SH1190
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000543: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000199383Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279808.SH1190.

Structurei

3D structure databases

ProteinModelPortaliQ4L776.
SMRiQ4L776. Positions 6-553.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4L776-1 [UniParc]FASTAAdd to Basket

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MAHLSDLDIA NQSELKPIGE IAEKAGIPAD ALEQYGHYKA KIDINQIKPK    50
DNKGKVVLVT AMSPTPAGEG KSTVTVGLSD AFNELKKNVM VALREPALGP 100
TFGIKGGATG GGYAQVLPME DINLHFNGDF HAITTANNAL SAFIDNHIHQ 150
GNELGIDVRR VEWKRVLDMN DRALRHVNVG LGGPTNGVPR EDGFNITVAS 200
EVMAILCLAR NINDLKEKIS RITIGYTRDR KPVTVADLKV EGALAMILKD 250
AIKPNLVQTI EGTPALVHGG PFANIAHGCN SILATETARD LADIVVTEAG 300
FGSDLGAEKF IDIKAREAGF EPSAVVLVAT VRALKMHGGV AKDDLKEENV 350
EAVKAGIVNL ERHVNNIRKF GVEPVIALNA FIHDTDAETE AVKAWAKENN 400
VRIALTEVWE KGGKGGVELA NQVLEVIEQP NDFKFLYDLD QSLEEKIETI 450
VKDIYGGSSV TFSKKAKKQL KEFTDNGWGQ YPICMAKTQY SFSDDATALG 500
APTDFDITIR ELEAKTGAGF IVALTGAIMT MPGLPKKPAA LNMDVTEDGH 550
AVGLF 555
Length:555
Mass (Da):59,718
Last modified:August 2, 2005 - v1
Checksum:i4F158417D278407C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006716 Genomic DNA. Translation: BAE04499.1.
RefSeqiWP_011275491.1. NC_007168.1.
YP_253105.1. NC_007168.1.

Genome annotation databases

EnsemblBacteriaiBAE04499; BAE04499; SH1190.
GeneIDi3482260.
KEGGisha:SH1190.
PATRICi19618499. VBIStaHae67511_1173.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006716 Genomic DNA. Translation: BAE04499.1 .
RefSeqi WP_011275491.1. NC_007168.1.
YP_253105.1. NC_007168.1.

3D structure databases

ProteinModelPortali Q4L776.
SMRi Q4L776. Positions 6-553.
ModBasei Search...

Protein-protein interaction databases

STRINGi 279808.SH1190.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE04499 ; BAE04499 ; SH1190 .
GeneIDi 3482260.
KEGGi sha:SH1190.
PATRICi 19618499. VBIStaHae67511_1173.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SHAE279808:GJX7-1244-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species."
    Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K.
    J. Bacteriol. 187:7292-7308(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCSC1435.

Entry informationi

Entry nameiFTHS_STAHJ
AccessioniPrimary (citable) accession number: Q4L776
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: August 2, 2005
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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