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Q4L750 (DHA_STAHJ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alanine dehydrogenase
EC=1.4.1.1
Gene names
Name:ald
Ordered Locus Names:SH1216
OrganismStaphylococcus haemolyticus (strain JCSC1435) [Complete proteome] [HAMAP]
Taxonomic identifier279808 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length373 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer By similarity.

Catalytic activity

L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH.

Pathway

Amino-acid degradation; L-alanine degradation via dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step 1/1.

Sequence similarities

Belongs to the AlaDH/PNT family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionalanine dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 373373Alanine dehydrogenase
PRO_0000287324

Regions

Nucleotide binding169 – 19931NAD By similarity

Sites

Active site951 Potential

Sequences

Sequence LengthMass (Da)Tools
Q4L750 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: 66E91EE689108294

FASTA37339,966
        10         20         30         40         50         60 
MKIGIPKEIK NNENRVGLSP SGVHALVEQG HTVLVEKDAG LGSFFEDKDY KDAGADIVSE 

        70         80         90        100        110        120 
QSSVWDVEMV IKVKEPLEEE YKYFKEGLIL FTYLHLANEE KLTQALVDNK VVGIAYETVQ 

       130        140        150        160        170        180 
LPDRSLPLLT PMSEVAGRMS AQVGSQFLQK FNGGMGILLG GVPGVPKGKV SIIGGGQAGT 

       190        200        210        220        230        240 
NAAKIALGLG ANVTILDVNP KRLAELDDLF DGRVNTIMSN PLNIENAVKE SDLVIGAVLI 

       250        260        270        280        290        300 
PGAKAPSLVT EDMIKQMKDG SVIVDIAIDQ GGIFETTDKI TTHDDPTYVK HGVVHYAVAN 

       310        320        330        340        350        360 
MPGAVPRTST IALNNATLPY AQLLASKGYR EAFKANHALS LGLNTYKGHV THKGVAEAFG 

       370 
LEYTSVEDAL KED

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References

[1]"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species."
Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K.
J. Bacteriol. 187:7292-7308(2005) [PubMed: 16237012] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JCSC1435.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006716 Genomic DNA. Translation: BAE04525.1.
RefSeqYP_253131.1. NC_007168.1.

3D structure databases

ProteinModelPortalQ4L750.
SMRQ4L750. Positions 1-371.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ4L750.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000046458; EBSTAP00000044909; EBSTAG00000046455.
GeneID3482407.
GenomeReviewsGene locus SH1216 in contig AP006716_GR.
KEGGsha:SH1216.
NMPDRfig|279808.3.peg.2455.
PATRIC19618551. VBIStaHae67511_1199.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0686.
GeneTreeEBGT00050000024386.
HOGENOMHBG289735.
OMAVAHGHEV.
PhylomeDBQ4L750.
ProtClustDBCLSK885510.

Enzyme and pathway databases

BioCycSHAE279808:SH1216-MONOMER.

Family and domain databases

InterProIPR008142. Ala_DH/PNT_CS1.
IPR008143. Ala_DH/PNT_CS2.
IPR008141. Ala_DH/Pyr_transHydgase.
IPR007886. AlaDH/PNT_N.
IPR007698. AlaDH/PNT_NAD(H)-bd.
[Graphical view]
KOK00259.
PANTHERPTHR10160:SF3. PTHR10160:SF3. 1 hit.
PfamPF01262. AlaDh_PNT_C. 1 hit.
PF05222. AlaDh_PNT_N. 1 hit.
[Graphical view]
PIRSFPIRSF000183. Alanine_dh. 1 hit.
SMARTSM01002. AlaDh_PNT_C. 1 hit.
SM01003. AlaDh_PNT_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR00518. AlaDH. 1 hit.
PROSITEPS00836. ALADH_PNT_1. 1 hit.
PS00837. ALADH_PNT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHA_STAHJ
AccessionPrimary (citable) accession number: Q4L750
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: August 2, 2005
Last modified: January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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