Q4L6U7 (AROE_STAHJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	SH1319

Organism

Staphylococcus haemolyticus (strain JCSC1435) [Complete proteome] [HAMAP]

Taxonomic identifier

279808 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	Shikimate dehydrogenase HAMAP MF_00222		PRO_1000021342
Regions
	Nucleotide binding	124 – 128	5	NADP By similarity
Sites
	Active site	64	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q4L6U7 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 105A82FAB93FA52E	FASTA	268	30,117
	10 20 30 40 50 60 MKYAVIGDPV SHSLSPVMHQ VNFKSLNMED TYEALHIPTQ DFHDIRHIIE DNHINGFNVT 70 80 90 100 110 120 IPHKERIIPY LDEINDQAKA VGAVNTVKII NNKWIGYNTD GIGYVMGLKQ VYPDLENAYV 130 140 150 160 170 180 LILGAGGASK GIANELSKIV QPKLTIANRT MSRFETWDMD INAISLEQSE QYLDEFDIII 190 200 210 220 230 240 NTTSAGLNNN DDIVISLDNL SSSTLVSDII YIPYKTKFLK EAEFKGNTVY NGLDMFINQG 250 260 AESFKIWTGK QPNILEMKYA VLNKLKGV

References

[1]

"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species." Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K. J. Bacteriol. 187:7292-7308(2005) [PubMed: 16237012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JCSC1435.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006716 Genomic DNA. Translation: BAE04628.1.
RefSeq	YP_253234.1. NC_007168.1.
3D structure databases
HSSP	HSSP built from PDB template 2GPT based on UniProtKB Q9SQT8.
ProteinModelPortal	Q4L6U7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4L6U7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000044624; EBSTAP00000043075; EBSTAG00000044622.
GeneID	3482392.
GenomeReviews	Gene locus SH1319 in contig AP006716_GR.
KEGG	sha:SH1319.
NMPDR	fig|279808.3.peg.1013.
PATRIC	19618751. VBIStaHae67511_1299.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0169.
GeneTree	EBGT00050000025479.
HOGENOM	HBG553408.
OMA	GIANELY.
PhylomeDB	Q4L6U7.
ProtClustDB	CLSK885454.
Enzyme and pathway databases
BioCyc	SHAE279808:SH1319-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_STAHJ

Accession

Primary (citable) accession number: Q4L6U7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 2, 2005
Last modified:	January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program