Q4L6K3 (P5CR_STAHJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyrroline-5-carboxylate reductase
Short name=P5C reductase
Short name=P5CR
EC=1.5.1.2

Gene names

Name:	proC
Ordered Locus Names:	SH1413

Organism

Staphylococcus haemolyticus (strain JCSC1435) [Complete proteome] [HAMAP]

Taxonomic identifier

279808 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Pyrroline-5-carboxylate reductase		PRO_0000187306

Sequences

	Sequence		Length	Mass (Da)
	Q4L6K3 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 90DAC8041979B794	FASTA	271	30,168
	10 20 30 40 50 60 MKLVFYGAGN MAQAIFKGII NSKKLKSHDI YLTNKSNEEA LKNFAEELGV EYSYDDEKLL 70 80 90 100 110 120 QDADYVFLGS KPYDFEKVAQ RIQPYINENN RFISIMAGLP INYIQEQLQV ENPIARIMPN 130 140 150 160 170 180 TNAQVGHSVT GISFSGNFGP KSKEEVNDLV NAFGSVIEVD EDHLHQVTAI TGSGPAFLYH 190 200 210 220 230 240 VFEQYVKAGT DLGLEKDQVE ESIKNLIIGT SKMIERSDLS MEQLRKNITS KGGTTQAGLN 250 260 270 ALAQHDIEAI FKDCLNAAVH RSVELSKNED N

References

[1]

"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species." Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K. J. Bacteriol. 187:7292-7308(2005) [PubMed: 16237012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JCSC1435.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006716 Genomic DNA. Translation: BAE04722.1.
RefSeq	YP_253328.1. NC_007168.1.
3D structure databases
ProteinModelPortal	Q4L6K3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4L6K3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000044469; EBSTAP00000042920; EBSTAG00000044467.
GeneID	3483380.
GenomeReviews	Gene locus SH1413 in contig AP006716_GR.
KEGG	sha:SH1413.
NMPDR	fig|279808.3.peg.1901.
PATRIC	19618939. VBIStaHae67511_1393.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0345.
GeneTree	EBGT00050000024862.
HOGENOM	HBG726602.
OMA	PIARIMP.
PhylomeDB	Q4L6K3.
ProtClustDB	CLSK885395.
Enzyme and pathway databases
BioCyc	SHAE279808:SH1413-MONOMER.
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. Pyrroline-COOH_reductase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00286.
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMs	TIGR00112. ProC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

P5CR_STAHJ

Accession

Primary (citable) accession number: Q4L6K3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	August 2, 2005
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program