Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glycerol-3-phosphate dehydrogenase [NAD(P)+]

Gene

gpsA

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H.

Pathwayi: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106NAD; via amide nitrogen1
Binding sitei106Substrate1
Binding sitei141NAD; via amide nitrogen1
Active sitei192Proton acceptor1
Binding sitei256NAD1
Binding sitei282NAD1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 13NAD6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00940.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC:1.1.1.94)
Alternative name(s):
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase
Gene namesi
Name:gpsA
Ordered Locus Names:SH1437
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000543 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001380311 – 332Glycerol-3-phosphate dehydrogenase [NAD(P)+]Add BLAST332

Interactioni

Protein-protein interaction databases

STRINGi279808.SH1437.

Structurei

3D structure databases

ProteinModelPortaliQ4L6H9.
SMRiQ4L6H9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni256 – 257Substrate binding2

Sequence similaritiesi

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

Phylogenomic databases

eggNOGiENOG4105CSF. Bacteria.
COG0240. LUCA.
HOGENOMiHOG000246854.
KOiK00057.
OMAiNMIGKGY.
OrthoDBiPOG091H060E.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
HAMAPiMF_00394. NAD_Glyc3P_dehydrog. 1 hit.
InterProiView protein in InterPro
IPR008927. 6-PGluconate_DH-like_C_sf.
IPR013328. 6PGD_dom2.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR011128. G3P_DH_NAD-dep_N.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00957. NAD_G3PDH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4L6H9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKITVFGMG SFGTALANVL AENGHTVLMW GKNEDSVKEL NDHHQNKRYL
60 70 80 90 100
KDVVLDSRIK ATSDIKEAAN FTDIYLMALP TKAMREVTSE IDSLIDSKKT
110 120 130 140 150
FIHVAKGIEN DTFKRVSEMI EDSISEDHNG GIGVLSGPSH AEEVVIKQPT
160 170 180 190 200
TVAASSKDEK VSKLIQDLFM NDYLRVYTNN DLVGVELGGA LKNIIAVASG
210 220 230 240 250
IVAGMGYGDN AKAALMTRGL AEISRLGEKL GADPMTFLGL GGIGDLIVTC
260 270 280 290 300
TSTHSRNYTL GFKLGQGQTM DEALNEMNMV VEGIYTTNSV YHLAKQQNVD
310 320 330
MPITNALYKV LFEDNPVKDS VKDLMGRDKK SE
Length:332
Mass (Da):36,188
Last modified:August 2, 2005 - v1
Checksum:iE79DE9980BA4D212
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA. Translation: BAE04746.1.
RefSeqiWP_011275732.1. NC_007168.1.

Genome annotation databases

EnsemblBacteriaiBAE04746; BAE04746; SH1437.
GeneIDi24245985.
KEGGisha:SH1437.

Similar proteinsi

Entry informationi

Entry nameiGPDA_STAHJ
AccessioniPrimary (citable) accession number: Q4L6H9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: August 2, 2005
Last modified: November 22, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families