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Protein

Nucleoside diphosphate kinase

Gene

ndk

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.UniRule annotation

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei9ATPUniRule annotation1
Binding sitei57ATPUniRule annotation1
Binding sitei85ATPUniRule annotation1
Binding sitei91ATPUniRule annotation1
Binding sitei102ATPUniRule annotation1
Binding sitei112ATPUniRule annotation1
Active sitei115Pros-phosphohistidine intermediateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processNucleotide metabolism
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSHAE279808:G1G27-1439-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinaseUniRule annotation (EC:2.7.4.6UniRule annotation)
Short name:
NDKUniRule annotation
Short name:
NDP kinaseUniRule annotation
Alternative name(s):
Nucleoside-2-P kinaseUniRule annotation
Gene namesi
Name:ndkUniRule annotation
Ordered Locus Names:SH1445
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000543 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002265811 – 149Nucleoside diphosphate kinaseAdd BLAST149

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ4L6H1

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi279808.SH1445

Structurei

3D structure databases

ProteinModelPortaliQ4L6H1
SMRiQ4L6H1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NDK family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UGX Bacteria
COG0105 LUCA
HOGENOMiHOG000224564
KOiK00940
OMAiKIVAMKM
OrthoDBiPOG091H040S

Family and domain databases

Gene3Di3.30.70.141, 1 hit
HAMAPiMF_00451 NDP_kinase, 1 hit
InterProiView protein in InterPro
IPR034907 NDK-like_dom
IPR036850 NDK-like_dom_sf
IPR001564 Nucleoside_diP_kinase
IPR023005 Nucleoside_diP_kinase_AS
PfamiView protein in Pfam
PF00334 NDK, 1 hit
PRINTSiPR01243 NUCDPKINASE
SMARTiView protein in SMART
SM00562 NDK, 1 hit
SUPFAMiSSF54919 SSF54919, 1 hit
PROSITEiView protein in PROSITE
PS00469 NDP_KINASES, 1 hit

Sequencei

Sequence statusi: Complete.

Q4L6H1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERTFLMIKP DAIQRNLVGE IISRIERKGL KLVGAKLMTV PQALAEEHYS
60 70 80 90 100
EHTDKPFYGK LISFITSAPV FAMVVEGEDA VDVSRHIIGK TNPSEATPGS
110 120 130 140
IRGDLGLTVG RNVIHGSDSV ESAQREINLW FKEEELSSYE APRDTWLYE
Length:149
Mass (Da):16,674
Last modified:August 2, 2005 - v1
Checksum:i153B322F30BB8589
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA Translation: BAE04754.1
RefSeqiWP_011275740.1, NC_007168.1

Genome annotation databases

EnsemblBacteriaiBAE04754; BAE04754; SH1445
GeneIDi24247259
KEGGisha:SH1445

Similar proteinsi

Entry informationi

Entry nameiNDK_STAHJ
AccessioniPrimary (citable) accession number: Q4L6H1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: August 2, 2005
Last modified: April 25, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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