Q4L6G8 (AROA_STAHJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	SH1448

Organism

Staphylococcus haemolyticus (strain JCSC1435) [Complete proteome] [HAMAP]

Taxonomic identifier

279808 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	432 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 432	432	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_1000012487

Sequences

	Sequence		Length	Mass (Da)
	Q4L6G8 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: EF1CB6A6821F89DA	FASTA	432	46,879
	10 20 30 40 50 60 MSNEQMIDIK GPLIGEIEVP GDKSMTHRAI MLASLATGQS TIYKPLLGED CLRTIEIFKL 70 80 90 100 110 120 LGVNIELAEE KIIVDSPGYN KFKTPHQTLY TGNSGTTTRL LAGLLSGLNL NCVLSGDASI 130 140 150 160 170 180 GKRPMDRVMK PLRLMGANIT GIDDNFTPLI IKPASINGIT YKMEVASAQV KSALLFASLF 190 200 210 220 230 240 SNDSSKITEL DVSRNHTETM FEQFNIPISI SGKEITTQPN AIEHIKAKDF YVPGDISSAA 250 260 270 280 290 300 FFIVAALITP GSDITIHNVG INPTRSGIID IVKQMEGNIE CLNITDTSEP TASIRVKYTP 310 320 330 340 350 360 NLKPVLIEGD IVPKAIDELP IIALLCTQAS GTSIIKDAEE LKVKETNRID TTADMLGLLG 370 380 390 400 410 420 FELQPTDDGL IIHPSEFKKS ATVDSLTDHR IGMMLAIASL LSDKPLNIRQ FDAVNVSFPG 430 FLPKLMLLEN EG

References

[1]

"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species." Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K. J. Bacteriol. 187:7292-7308(2005) [PubMed: 16237012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JCSC1435.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006716 Genomic DNA. Translation: BAE04757.1.
RefSeq	YP_253363.1. NC_007168.1.
3D structure databases
ProteinModelPortal	Q4L6G8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4L6G8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000046499; EBSTAP00000044950; EBSTAG00000046496.
GeneID	3482389.
GenomeReviews	Gene locus SH1448 in contig AP006716_GR.
KEGG	sha:SH1448.
NMPDR	fig|279808.3.peg.2008.
PATRIC	19619007. VBIStaHae67511_1427.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0128.
GeneTree	EBGT00050000024855.
HOGENOM	HBG646626.
OMA	VVMVMAT.
PhylomeDB	Q4L6G8.
ProtClustDB	PRK02427.
Enzyme and pathway databases
BioCyc	SHAE279808:SH1448-MONOMER.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_STAHJ

Accession

Primary (citable) accession number: Q4L6G8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 2, 2005
Last modified:	January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program