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Protein

Signal transduction histidine-protein kinase ArlS

Gene

arlS

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Member of the two-component regulatory system ArlS/ArlR. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to ArlR (By similarity).By similarity

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Two-component regulatory system

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSHAE279808:GJX7-1545-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transduction histidine-protein kinase ArlS (EC:2.7.13.3)
Gene namesi
Name:arlS
Ordered Locus Names:SH1491
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000543 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei14 – 3421HelicalSequence analysisAdd
BLAST
Transmembranei157 – 17721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453Signal transduction histidine-protein kinase ArlSPRO_0000293451Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei243 – 2431Phosphohistidine; by autocatalysisPROSITE-ProRule annotation

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi279808.SH1491.

Structurei

3D structure databases

ProteinModelPortaliQ4L6C5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini179 – 23254HAMPPROSITE-ProRule annotationAdd
BLAST
Domaini240 – 453214Histidine kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HAMP domain.PROSITE-ProRule annotation
Contains 1 histidine kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105GR3. Bacteria.
COG0642. LUCA.
HOGENOMiHOG000223177.
KOiK18940.
OMAiASSINQM.
OrthoDBiEOG6G4VQG.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4L6C5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKKGTLKYK WMMITTLIMF STIILFCLVI IFFLKDTLRD GEIDEAEHSS
60 70 80 90 100
SEIVNLVESR SMNNITTLDL TAMLENFEKA IIYDRNGKQL MQSSNENMIN
110 120 130 140 150
FKPDIDFVDP ETIQISKHNG IPYLIITEPI HSERFEGYSV LIHSLEGYNN
160 170 180 190 200
VVRSLYFVAI AFGLLATFIM AGISYIFSTQ LTKPLVTMSN KMIQIRRDGF
210 220 230 240 250
QNKLELKTNY EETDNLIDTF NDMMYQIEES FNQQRQFVED ASHELRTPLQ
260 270 280 290 300
IIQGHLNLIQ RWGKKDPAVL EESLNISLEE MNRITKLVEE LLLLTKDKVN
310 320 330 340 350
IQALEFEEVN INEEIRSRIK SLKQLHPDYQ FKTHLSKKPL TLQINRHQFE
360 370 380 390 400
QLLLIFIDNA MKYDKDNKQI EIATQLRNKQ ISIEITDHGL GIPKEDQEFI
410 420 430 440 450
FDRFYRVDKS RSRSQGGNGL GLFIAEKIVQ QYGGYITVDS EVNQYTTFKI

IFK
Length:453
Mass (Da):52,861
Last modified:August 2, 2005 - v1
Checksum:iD8021E99B1E335BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA. Translation: BAE04800.1.
RefSeqiWP_011275786.1. NC_007168.1.

Genome annotation databases

EnsemblBacteriaiBAE04800; BAE04800; SH1491.
GeneIDi24245895.
KEGGisha:SH1491.
PATRICi19619093. VBIStaHae67511_1470.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA. Translation: BAE04800.1.
RefSeqiWP_011275786.1. NC_007168.1.

3D structure databases

ProteinModelPortaliQ4L6C5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi279808.SH1491.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAE04800; BAE04800; SH1491.
GeneIDi24245895.
KEGGisha:SH1491.
PATRICi19619093. VBIStaHae67511_1470.

Phylogenomic databases

eggNOGiENOG4105GR3. Bacteria.
COG0642. LUCA.
HOGENOMiHOG000223177.
KOiK18940.
OMAiASSINQM.
OrthoDBiEOG6G4VQG.

Enzyme and pathway databases

BioCyciSHAE279808:GJX7-1545-MONOMER.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species."
    Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K.
    J. Bacteriol. 187:7292-7308(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCSC1435.

Entry informationi

Entry nameiARLS_STAHJ
AccessioniPrimary (citable) accession number: Q4L6C5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: August 2, 2005
Last modified: June 8, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.