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Protein

Signal transduction histidine-protein kinase ArlS

Gene

arlS

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Member of the two-component regulatory system ArlS/ArlR. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to ArlR (By similarity).By similarity

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
Biological processTwo-component regulatory system
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSHAE279808:G1G27-1487-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transduction histidine-protein kinase ArlS (EC:2.7.13.3)
Gene namesi
Name:arlS
Ordered Locus Names:SH1491
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000543 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002934511 – 453Signal transduction histidine-protein kinase ArlSAdd BLAST453

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei243Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ4L6C5

Interactioni

Protein-protein interaction databases

STRINGi279808.SH1491

Structurei

3D structure databases

ProteinModelPortaliQ4L6C5
SMRiQ4L6C5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini179 – 232HAMPPROSITE-ProRule annotationAdd BLAST54
Domaini240 – 453Histidine kinasePROSITE-ProRule annotationAdd BLAST214

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105GR3 Bacteria
COG0642 LUCA
HOGENOMiHOG000223177
KOiK18940
OMAiMTIMIND
OrthoDBiPOG091H02OU

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
cd00082 HisKA, 1 hit
Gene3Di3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR003660 HAMP_dom
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR005467 His_kinase_dom
IPR003661 HisK_dim/P
IPR036097 HisK_dim/P_sf
IPR004358 Sig_transdc_His_kin-like_C
PfamiView protein in Pfam
PF02518 HATPase_c, 1 hit
PF00512 HisKA, 1 hit
PRINTSiPR00344 BCTRLSENSOR
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SM00388 HisKA, 1 hit
SUPFAMiSSF47384 SSF47384, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS50885 HAMP, 1 hit
PS50109 HIS_KIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q4L6C5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKKGTLKYK WMMITTLIMF STIILFCLVI IFFLKDTLRD GEIDEAEHSS
60 70 80 90 100
SEIVNLVESR SMNNITTLDL TAMLENFEKA IIYDRNGKQL MQSSNENMIN
110 120 130 140 150
FKPDIDFVDP ETIQISKHNG IPYLIITEPI HSERFEGYSV LIHSLEGYNN
160 170 180 190 200
VVRSLYFVAI AFGLLATFIM AGISYIFSTQ LTKPLVTMSN KMIQIRRDGF
210 220 230 240 250
QNKLELKTNY EETDNLIDTF NDMMYQIEES FNQQRQFVED ASHELRTPLQ
260 270 280 290 300
IIQGHLNLIQ RWGKKDPAVL EESLNISLEE MNRITKLVEE LLLLTKDKVN
310 320 330 340 350
IQALEFEEVN INEEIRSRIK SLKQLHPDYQ FKTHLSKKPL TLQINRHQFE
360 370 380 390 400
QLLLIFIDNA MKYDKDNKQI EIATQLRNKQ ISIEITDHGL GIPKEDQEFI
410 420 430 440 450
FDRFYRVDKS RSRSQGGNGL GLFIAEKIVQ QYGGYITVDS EVNQYTTFKI

IFK
Length:453
Mass (Da):52,861
Last modified:August 2, 2005 - v1
Checksum:iD8021E99B1E335BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA Translation: BAE04800.1
RefSeqiWP_011275786.1, NC_007168.1

Genome annotation databases

EnsemblBacteriaiBAE04800; BAE04800; SH1491
GeneIDi24245895
KEGGisha:SH1491

Similar proteinsi

Entry informationi

Entry nameiARLS_STAHJ
AccessioniPrimary (citable) accession number: Q4L6C5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: August 2, 2005
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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