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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

odhA

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).UniRule annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

thiamine diphosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandThiamine pyrophosphate

Enzyme and pathway databases

BioCyciSHAE279808:G1G27-1488-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 componentUniRule annotation (EC:1.2.4.2UniRule annotation)
Alternative name(s):
Alpha-ketoglutarate dehydrogenaseUniRule annotation
Gene namesi
Name:odhAUniRule annotation
Ordered Locus Names:SH1492
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000543 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001621841 – 9342-oxoglutarate dehydrogenase E1 componentAdd BLAST934

Proteomic databases

PRIDEiQ4L6C4

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi279808.SH1492

Structurei

3D structure databases

ProteinModelPortaliQ4L6C4
SMRiQ4L6C4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-ketoglutarate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C7P Bacteria
COG0567 LUCA
HOGENOMiHOG000259588
KOiK00164
OMAiIDMVCYR
OrthoDBiPOG091H03SK

Family and domain databases

HAMAPiMF_01169 SucA_OdhA, 1 hit
InterProiView protein in InterPro
IPR011603 2oxoglutarate_DH_E1
IPR023784 2oxoglutarate_DH_E1_bac
IPR001017 DH_E1
IPR031717 KGD_C
IPR029061 THDP-binding
IPR005475 Transketolase-like_Pyr-bd
PANTHERiPTHR23152 PTHR23152, 1 hit
PfamiView protein in Pfam
PF00676 E1_dh, 1 hit
PF16870 OxoGdeHyase_C, 1 hit
PF02779 Transket_pyr, 1 hit
PIRSFiPIRSF000157 Oxoglu_dh_E1, 1 hit
SMARTiView protein in SMART
SM00861 Transket_pyr, 1 hit
SUPFAMiSSF52518 SSF52518, 2 hits
TIGRFAMsiTIGR00239 2oxo_dh_E1, 1 hit

Sequencei

Sequence statusi: Complete.

Q4L6C4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKDNKDVTE APVNFGANLG LMLDLYDDYL QDPSSVPDDL QVLFSTIKNG
60 70 80 90 100
EAHVAAKSTT EGSGSSAGDG TIKRIMRLID NIRQYGHLKA DIYPVNAPKR
110 120 130 140 150
TNLPKLEIEE FNLDKETLEN VSAEIVSDHF KDIYDNAYEA IERMEKRYKG
160 170 180 190 200
PIAFEYNHIN NNKERTWLKR RIETPYRANI NNDERKKLFD TLAHVEGFEK
210 220 230 240 250
YLHKNFVGAK RFSIEGVDTL VPMLQHTLKR AAEIEINNIQ IGMAHRGRLN
260 270 280 290 300
VLTHVLEKPY EMMISEFMHT DPMKFLPEDG SLELTAGWTG DVKYHLGGVK
310 320 330 340 350
TTSSYGIEQR ISLANNPSHL EIVAPVVIGK TRASQDDTKH AGKPTTDFHK
360 370 380 390 400
GMPIIIHGDA AYPGQGINFE TMNLSNLDGY STGGALHIIT NNRIGFTTEP
410 420 430 440 450
VDGRSTTYST DIAKGYDVPI LHVNADDVEA TIEAIDIAME FRKEFHKDFV
460 470 480 490 500
IDLVGYRRYG HNEMDEPSIT NPLPYHNIRK HDSVEIIYGN KLVEDGVISK
510 520 530 540 550
EQMEDVMDKV QKEMRAAQDK IDKSDKMDNP DMERPESLQE PLQSDDKDFS
560 570 580 590 600
VDHLKEINDA MLTYPEDFHV LKKLNKVLEK RREPFESENG LVDWAQAEQL
610 620 630 640 650
AFATIVQDGI SVRLTGQDSE RGTFSHRHAV LHDEENGDTF TPLHHVPNQK
660 670 680 690 700
ATFEVHNSPL SEAAVVGFEY GYNVENKNSM NIWEAQYGDF SNMAQMMFDN
710 720 730 740 750
FMSSARAKWG ERSGLTLFLP HAFEGQGPEH SSARLERFLQ LAAENNSTVV
760 770 780 790 800
NLSSSSNYFH LLRAQAKSLG TEAMRPLIVM SPKSLLRNKT VAKPIDQFTS
810 820 830 840 850
GGFKPIIVED GNKEKVTKLV LASGKMFIDL KEHLAKNPDD SILLVAVDRL
860 870 880 890 900
YPFPEGEIKE VLNELPNLET VSWVQEEPKN QGAWLFVYPY LKSLVGNQFN
910 920 930
LSYHGRIQRA APAEGDGEIH KLVQNQIIES SIEK
Length:934
Mass (Da):105,479
Last modified:August 2, 2005 - v1
Checksum:i7D9E801A49E880E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA Translation: BAE04801.1
RefSeqiWP_011275787.1, NC_007168.1

Genome annotation databases

EnsemblBacteriaiBAE04801; BAE04801; SH1492
GeneIDi24245825
KEGGisha:SH1492

Similar proteinsi

Entry informationi

Entry nameiODO1_STAHJ
AccessioniPrimary (citable) accession number: Q4L6C4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: August 2, 2005
Last modified: April 25, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome