Reviewed, UniProtKB/Swiss-Prot Q4L6C4 (ODO1_STAHJ)

Names and origin

Protein names

Recommended name:
    2-oxoglutarate dehydrogenase E1 component
    EC=1.2.4.2
Alternative name(s):
    Alpha-ketoglutarate dehydrogenase

Gene names

Name:	odhA
Ordered Locus Names:	SH1492

Organism

Staphylococcus haemolyticus (strain JCSC1435) [Complete proteome] [HAMAP]

Taxonomic identifier

279808 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	934 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.
Catalytic activity	2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. HAMAP MF_01169
Cofactor	Thiamine pyrophosphate By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Thiamine pyrophosphate
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from electronic annotation. Source: HAMAP thiamin pyrophosphate binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 934	934	2-oxoglutarate dehydrogenase E1 component HAMAP MF_01169		PRO_0000162184

Sequences

	Sequence		Length	Mass (Da)
	Q4L6C4-1 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 7D9E801A49E880E9	FASTA	934	105,479
	10 20 30 40 50 60 MAKDNKDVTE APVNFGANLG LMLDLYDDYL QDPSSVPDDL QVLFSTIKNG EAHVAAKSTT 70 80 90 100 110 120 EGSGSSAGDG TIKRIMRLID NIRQYGHLKA DIYPVNAPKR TNLPKLEIEE FNLDKETLEN 130 140 150 160 170 180 VSAEIVSDHF KDIYDNAYEA IERMEKRYKG PIAFEYNHIN NNKERTWLKR RIETPYRANI 190 200 210 220 230 240 NNDERKKLFD TLAHVEGFEK YLHKNFVGAK RFSIEGVDTL VPMLQHTLKR AAEIEINNIQ 250 260 270 280 290 300 IGMAHRGRLN VLTHVLEKPY EMMISEFMHT DPMKFLPEDG SLELTAGWTG DVKYHLGGVK 310 320 330 340 350 360 TTSSYGIEQR ISLANNPSHL EIVAPVVIGK TRASQDDTKH AGKPTTDFHK GMPIIIHGDA 370 380 390 400 410 420 AYPGQGINFE TMNLSNLDGY STGGALHIIT NNRIGFTTEP VDGRSTTYST DIAKGYDVPI 430 440 450 460 470 480 LHVNADDVEA TIEAIDIAME FRKEFHKDFV IDLVGYRRYG HNEMDEPSIT NPLPYHNIRK 490 500 510 520 530 540 HDSVEIIYGN KLVEDGVISK EQMEDVMDKV QKEMRAAQDK IDKSDKMDNP DMERPESLQE 550 560 570 580 590 600 PLQSDDKDFS VDHLKEINDA MLTYPEDFHV LKKLNKVLEK RREPFESENG LVDWAQAEQL 610 620 630 640 650 660 AFATIVQDGI SVRLTGQDSE RGTFSHRHAV LHDEENGDTF TPLHHVPNQK ATFEVHNSPL 670 680 690 700 710 720 SEAAVVGFEY GYNVENKNSM NIWEAQYGDF SNMAQMMFDN FMSSARAKWG ERSGLTLFLP 730 740 750 760 770 780 HAFEGQGPEH SSARLERFLQ LAAENNSTVV NLSSSSNYFH LLRAQAKSLG TEAMRPLIVM 790 800 810 820 830 840 SPKSLLRNKT VAKPIDQFTS GGFKPIIVED GNKEKVTKLV LASGKMFIDL KEHLAKNPDD 850 860 870 880 890 900 SILLVAVDRL YPFPEGEIKE VLNELPNLET VSWVQEEPKN QGAWLFVYPY LKSLVGNQFN 910 920 930 LSYHGRIQRA APAEGDGEIH KLVQNQIIES SIEK

References

[1]

"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species." Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K. J. Bacteriol. 187:7292-7308(2005) [PubMed: 16237012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP006716 Genomic DNA. Translation: BAE04801.1.
RefSeq	YP_253407.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3481998.
GenomeReviews	Gene locus SH1492 in contig AP006716_GR.
KEGG	sha:SH1492.
NMPDR	fig|279808.3.peg.2139.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4L6C4.
OMA	Q4L6C4. FEEFLQI.
Enzyme and pathway databases
BioCyc	SHAE279808:SH1492-MON.
Family and domain databases
HAMAP	MF_01169. [Tree]
InterPro	IPR011603. 2oxoglutarate_DH_E1. IPR001017. DH_E1. IPR005475. Transketolase_central-reg. [Graphical view]
PANTHER	PTHR23152. 2oxoglutarate_DH_E1. 1 hit.
Pfam	PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view]
PIRSF	PIRSF000157. Oxoglu_dh_E1. 1 hit.
TIGRFAMs	TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ODO1_STAHJ

Accession

Primary (citable) accession number: Q4L6C4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
Last sequence update:	August 2, 2005
Last modified:	June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)