ID   TYRA_STAHJ              Reviewed;         363 AA.
AC   Q4L672;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   16-JUN-2009, entry version 29.
DE   RecName: Full=Prephenate dehydrogenase;
DE            Short=PDH;
DE            EC=1.3.1.12;
GN   Name=tyrA; OrderedLocusNames=SH1544;
OS   Staphylococcus haemolyticus (strain JCSC1435).
OC   Bacteria; Firmicutes; Bacillales; Staphylococcus.
OX   NCBI_TaxID=279808;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16237012; DOI=10.1128/JB.187.21.7292-7308.2005;
RA   Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA   Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S.,
RA   Lee J.C., Hiramatsu K.;
RT   "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT   extreme plasticity of its genome and the evolution of human-colonizing
RT   staphylococcal species.";
RL   J. Bacteriol. 187:7292-7308(2005).
CC   -!- CATALYTIC ACTIVITY: Prephenate + NAD(+) = 4-hydroxyphenylpyruvate
CC       + CO(2) + NADH.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tyrosine biosynthesis; L-
CC       tyrosine from prephenate: step 1/2.
CC   -!- SIMILARITY: Contains 1 ACT domain.
CC   -!- SIMILARITY: Contains 1 prephenate/arogenate dehydrogenase domain.
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DR   EMBL; AP006716; BAE04853.1; -; Genomic_DNA.
DR   RefSeq; YP_253459.1; -.
DR   GeneID; 3481626; -.
DR   GenomeReviews; AP006716_GR; SH1544.
DR   KEGG; sha:SH1544; -.
DR   NMPDR; fig|279808.3.peg.2461; -.
DR   HOGENOM; Q4L672; -.
DR   OMA; Q4L672; QRAIRWG.
DR   BioCyc; SHAE279808:SH1544-MON; -.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0008977; F:prephenate dehydrogenase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006571; P:tyrosine biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002912; ACT_bd.
DR   InterPro; IPR003099; Prephen_DH.
DR   PANTHER; PTHR21363; Prephen_DH; 1.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF02153; PDH; 1.
DR   PROSITE; PS51176; PDH_ADH; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; NAD; Oxidoreductase; Tyrosine biosynthesis.
FT   CHAIN         1    363       Prephenate dehydrogenase.
FT                                /FTId=PRO_0000282665.
FT   DOMAIN        2    291       Prephenate/arogenate dehydrogenase.
FT   DOMAIN      295    360       ACT.
FT   NP_BIND       3     33       NAD (Potential).
SQ   SEQUENCE   363 AA;  40442 MW;  4E34B068A10921BC CRC64;
     MKNILFIGLG LIGGSLASNL KYYQPNLTIS AFDADKDQLE KALSIGIIDK KIEDYSEGVK
     NADIIIYATP VQQTELYLKE LPNYQTQSHL IVTDTGSTKS NIQSYEKFLL NNDIHLVGGH
     PMAGSHKSGV LNSKKHLFEN AYYILVYDDA RNAESAKKLQ TLLSTTSAKF ITTSAQEHDY
     VTGVVSHIPH IIASSLVHLS ETNSKNHTLV TQLAAGGFRD VTRIASSNAD MWRDITFSNQ
     ENILHLLEML QQQLDSISSH IRLNDTNEVH SFFSGAKKFR DQLPVKQQGA LSIAYDLYVD
     IPDKSGMISK VTSILSLHNI SISNLKILEI REDILGALQI SFKTPEDRER GIKALSDFET
     YIL
//