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Q4L672 (TYRA_STAHJ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prephenate dehydrogenase

Short name=PDH
EC=1.3.1.12
Gene names
Name:tyrA
Ordered Locus Names:SH1544
OrganismStaphylococcus haemolyticus (strain JCSC1435) [Complete proteome] [HAMAP]
Taxonomic identifier279808 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Catalytic activity

Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathway

Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.

Sequence similarities

Contains 1 ACT domain.

Contains 1 prephenate/arogenate dehydrogenase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363Prephenate dehydrogenase
PRO_0000282665

Regions

Domain2 – 291290Prephenate/arogenate dehydrogenase
Domain296 – 36368ACT
Nucleotide binding3 – 3331NAD Potential

Sequences

Sequence LengthMass (Da)Tools
Q4L672 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: 4E34B068A10921BC

FASTA36340,442
        10         20         30         40         50         60 
MKNILFIGLG LIGGSLASNL KYYQPNLTIS AFDADKDQLE KALSIGIIDK KIEDYSEGVK 

        70         80         90        100        110        120 
NADIIIYATP VQQTELYLKE LPNYQTQSHL IVTDTGSTKS NIQSYEKFLL NNDIHLVGGH 

       130        140        150        160        170        180 
PMAGSHKSGV LNSKKHLFEN AYYILVYDDA RNAESAKKLQ TLLSTTSAKF ITTSAQEHDY 

       190        200        210        220        230        240 
VTGVVSHIPH IIASSLVHLS ETNSKNHTLV TQLAAGGFRD VTRIASSNAD MWRDITFSNQ 

       250        260        270        280        290        300 
ENILHLLEML QQQLDSISSH IRLNDTNEVH SFFSGAKKFR DQLPVKQQGA LSIAYDLYVD 

       310        320        330        340        350        360 
IPDKSGMISK VTSILSLHNI SISNLKILEI REDILGALQI SFKTPEDRER GIKALSDFET 


YIL 

« Hide

References

[1]"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species."
Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K.
J. Bacteriol. 187:7292-7308(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JCSC1435.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP006716 Genomic DNA. Translation: BAE04853.1.
RefSeqYP_253459.1. NC_007168.1.

3D structure databases

ProteinModelPortalQ4L672.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING279808.SH1544.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAE04853; BAE04853; SH1544.
GeneID3481626.
KEGGsha:SH1544.
PATRIC19619195. VBIStaHae67511_1521.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0287.
HOGENOMHOG000043494.
KOK04517.
OMALQITFKN.
OrthoDBEOG6B8XMB.

Enzyme and pathway databases

BioCycSHAE279808:GJX7-1598-MONOMER.
UniPathwayUPA00122; UER00961.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR002912. ACT_dom.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view]
PfamPF01842. ACT. 1 hit.
PF02153. PDH. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
PROSITEPS51671. ACT. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYRA_STAHJ
AccessionPrimary (citable) accession number: Q4L672
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: August 2, 2005
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways