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Q4L672

- TYRA_STAHJ

UniProt

Q4L672 - TYRA_STAHJ

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Protein
Prephenate dehydrogenase
Gene
tyrA, SH1544
Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Catalytic activityi

Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi3 – 3331NAD Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. prephenate dehydrogenase (NADP+) activity Source: InterPro
  3. prephenate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. tyrosine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSHAE279808:GJX7-1598-MONOMER.
UniPathwayiUPA00122; UER00961.

Names & Taxonomyi

Protein namesi
Recommended name:
Prephenate dehydrogenase (EC:1.3.1.12)
Short name:
PDH
Gene namesi
Name:tyrA
Ordered Locus Names:SH1544
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000543: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363Prephenate dehydrogenase
PRO_0000282665Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279808.SH1544.

Structurei

3D structure databases

ProteinModelPortaliQ4L672.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 291290Prephenate/arogenate dehydrogenase
Add
BLAST
Domaini296 – 36368ACT
Add
BLAST

Sequence similaritiesi

Contains 1 ACT domain.

Phylogenomic databases

eggNOGiCOG0287.
HOGENOMiHOG000043494.
KOiK04517.
OMAiLQITFKN.
OrthoDBiEOG6B8XMB.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR002912. ACT_dom.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF02153. PDH. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4L672-1 [UniParc]FASTAAdd to Basket

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MKNILFIGLG LIGGSLASNL KYYQPNLTIS AFDADKDQLE KALSIGIIDK    50
KIEDYSEGVK NADIIIYATP VQQTELYLKE LPNYQTQSHL IVTDTGSTKS 100
NIQSYEKFLL NNDIHLVGGH PMAGSHKSGV LNSKKHLFEN AYYILVYDDA 150
RNAESAKKLQ TLLSTTSAKF ITTSAQEHDY VTGVVSHIPH IIASSLVHLS 200
ETNSKNHTLV TQLAAGGFRD VTRIASSNAD MWRDITFSNQ ENILHLLEML 250
QQQLDSISSH IRLNDTNEVH SFFSGAKKFR DQLPVKQQGA LSIAYDLYVD 300
IPDKSGMISK VTSILSLHNI SISNLKILEI REDILGALQI SFKTPEDRER 350
GIKALSDFET YIL 363
Length:363
Mass (Da):40,442
Last modified:August 2, 2005 - v1
Checksum:i4E34B068A10921BC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006716 Genomic DNA. Translation: BAE04853.1.
RefSeqiYP_253459.1. NC_007168.1.

Genome annotation databases

EnsemblBacteriaiBAE04853; BAE04853; SH1544.
GeneIDi3481626.
KEGGisha:SH1544.
PATRICi19619195. VBIStaHae67511_1521.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006716 Genomic DNA. Translation: BAE04853.1 .
RefSeqi YP_253459.1. NC_007168.1.

3D structure databases

ProteinModelPortali Q4L672.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 279808.SH1544.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE04853 ; BAE04853 ; SH1544 .
GeneIDi 3481626.
KEGGi sha:SH1544.
PATRICi 19619195. VBIStaHae67511_1521.

Phylogenomic databases

eggNOGi COG0287.
HOGENOMi HOG000043494.
KOi K04517.
OMAi LQITFKN.
OrthoDBi EOG6B8XMB.

Enzyme and pathway databases

UniPathwayi UPA00122 ; UER00961 .
BioCyci SHAE279808:GJX7-1598-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR002912. ACT_dom.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view ]
Pfami PF01842. ACT. 1 hit.
PF02153. PDH. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
PROSITEi PS51671. ACT. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species."
    Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K.
    J. Bacteriol. 187:7292-7308(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCSC1435.

Entry informationi

Entry nameiTYRA_STAHJ
AccessioniPrimary (citable) accession number: Q4L672
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: August 2, 2005
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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