Reviewed, UniProtKB/Swiss-Prot Q4L672 (TYRA_STAHJ)

Names and origin

Protein names

Recommended name:
    Prephenate dehydrogenase
      Short name=PDH
    EC=1.3.1.12

Gene names

Name:	tyrA
Ordered Locus Names:	SH1544

Organism

Staphylococcus haemolyticus (strain JCSC1435) [Complete proteome] [HAMAP]

Taxonomic identifier

279808 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	363 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Predicted.

General annotation (Comments)

Catalytic activity	Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.
Pathway	Amino-acid biosynthesis; L-tyrosine biosynthesis; L-tyrosine from prephenate: step 1/2.
Sequence similarities	Contains 1 ACT domain. Contains 1 prephenate/arogenate dehydrogenase domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tyrosine biosynthesis
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro prephenate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: InterPro prephenate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 363	363	Prephenate dehydrogenase		PRO_0000282665
Regions
	Domain	2 – 291	290	Prephenate/arogenate dehydrogenase
	Domain	295 – 360	66	ACT
	Nucleotide binding	3 – 33	31	NAD Potential

Sequences

	Sequence		Length	Mass (Da)
	Q4L672-1 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 4E34B068A10921BC	FASTA	363	40,442
	10 20 30 40 50 60 MKNILFIGLG LIGGSLASNL KYYQPNLTIS AFDADKDQLE KALSIGIIDK KIEDYSEGVK 70 80 90 100 110 120 NADIIIYATP VQQTELYLKE LPNYQTQSHL IVTDTGSTKS NIQSYEKFLL NNDIHLVGGH 130 140 150 160 170 180 PMAGSHKSGV LNSKKHLFEN AYYILVYDDA RNAESAKKLQ TLLSTTSAKF ITTSAQEHDY 190 200 210 220 230 240 VTGVVSHIPH IIASSLVHLS ETNSKNHTLV TQLAAGGFRD VTRIASSNAD MWRDITFSNQ 250 260 270 280 290 300 ENILHLLEML QQQLDSISSH IRLNDTNEVH SFFSGAKKFR DQLPVKQQGA LSIAYDLYVD 310 320 330 340 350 360 IPDKSGMISK VTSILSLHNI SISNLKILEI REDILGALQI SFKTPEDRER GIKALSDFET YIL

References

[1]

"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species." Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K. J. Bacteriol. 187:7292-7308(2005) [PubMed: 16237012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP006716 Genomic DNA. Translation: BAE04853.1.
RefSeq	YP_253459.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q4L672.
Genome annotation databases
GeneID	3481626.
GenomeReviews	Gene locus SH1544 in contig AP006716_GR.
KEGG	sha:SH1544.
NMPDR	fig|279808.3.peg.2461.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4L672.
OMA	QRAIRWG.
Enzyme and pathway databases
BioCyc	SHAE279808:SH1544-MON.
Family and domain databases
InterPro	IPR002912. ACT_bd. IPR003099. Prephen_DH. [Graphical view]
PANTHER	PTHR21363. Prephen_DH. 1 hit.
Pfam	PF01842. ACT. 1 hit. PF02153. PDH. 1 hit. [Graphical view]
PROSITE	PS51176. PDH_ADH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYRA_STAHJ

Accession

Primary (citable) accession number: Q4L672

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	August 2, 2005
Last modified:	November 3, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)