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Protein

Prephenate dehydrogenase

Gene

tyrA

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathwayi: L-tyrosine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route).
Proteins known to be involved in this subpathway in this organism are:
  1. Prephenate dehydrogenase (tyrA)
This subpathway is part of the pathway L-tyrosine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route), the pathway L-tyrosine biosynthesis and in Amino-acid biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi3 – 33NADSequence analysisAdd BLAST31

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00122; UER00961.

Names & Taxonomyi

Protein namesi
Recommended name:
Prephenate dehydrogenase (EC:1.3.1.12)
Short name:
PDH
Gene namesi
Name:tyrA
Ordered Locus Names:SH1544
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000543 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002826651 – 363Prephenate dehydrogenaseAdd BLAST363

Interactioni

Protein-protein interaction databases

STRINGi279808.SH1544.

Structurei

3D structure databases

ProteinModelPortaliQ4L672.
SMRiQ4L672.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 291Prephenate/arogenate dehydrogenasePROSITE-ProRule annotationAdd BLAST290
Domaini296 – 363ACTPROSITE-ProRule annotationAdd BLAST68

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105EVN. Bacteria.
COG0287. LUCA.
HOGENOMiHOG000043494.
KOiK04517.
OMAiMWRDICL.
OrthoDBiPOG091H02BW.

Family and domain databases

InterProiView protein in InterPro
IPR008927. 6-PGluconate_DH_C-like.
IPR002912. ACT_dom.
IPR036291. NAD(P)-bd_dom_sf.
IPR003099. Prephen_DH.
PfamiView protein in Pfam
PF02153. PDH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS51671. ACT. 1 hit.
PS51176. PDH_ADH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4L672-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNILFIGLG LIGGSLASNL KYYQPNLTIS AFDADKDQLE KALSIGIIDK
60 70 80 90 100
KIEDYSEGVK NADIIIYATP VQQTELYLKE LPNYQTQSHL IVTDTGSTKS
110 120 130 140 150
NIQSYEKFLL NNDIHLVGGH PMAGSHKSGV LNSKKHLFEN AYYILVYDDA
160 170 180 190 200
RNAESAKKLQ TLLSTTSAKF ITTSAQEHDY VTGVVSHIPH IIASSLVHLS
210 220 230 240 250
ETNSKNHTLV TQLAAGGFRD VTRIASSNAD MWRDITFSNQ ENILHLLEML
260 270 280 290 300
QQQLDSISSH IRLNDTNEVH SFFSGAKKFR DQLPVKQQGA LSIAYDLYVD
310 320 330 340 350
IPDKSGMISK VTSILSLHNI SISNLKILEI REDILGALQI SFKTPEDRER
360
GIKALSDFET YIL
Length:363
Mass (Da):40,442
Last modified:August 2, 2005 - v1
Checksum:i4E34B068A10921BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA. Translation: BAE04853.1.
RefSeqiWP_011275835.1. NC_007168.1.

Genome annotation databases

EnsemblBacteriaiBAE04853; BAE04853; SH1544.
GeneIDi24247508.
KEGGisha:SH1544.

Similar proteinsi

Entry informationi

Entry nameiTYRA_STAHJ
AccessioniPrimary (citable) accession number: Q4L672
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: August 2, 2005
Last modified: October 25, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families