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Protein

Aerobic glycerol-3-phosphate dehydrogenase

Gene

glpD

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

Cofactori

FADBy similarity

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (aerobic route).
Proteins known to be involved in this subpathway in this organism are:
  1. Aerobic glycerol-3-phosphate dehydrogenase (glpD)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (aerobic route), the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 49FADSequence analysisAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycerol metabolism
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciSHAE279808:G1G27-1599-MONOMER
UniPathwayiUPA00618; UER00674

Names & Taxonomyi

Protein namesi
Recommended name:
Aerobic glycerol-3-phosphate dehydrogenase (EC:1.1.5.3)
Gene namesi
Name:glpD
Ordered Locus Names:SH1608
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000543 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002700671 – 557Aerobic glycerol-3-phosphate dehydrogenaseAdd BLAST557

Interactioni

Protein-protein interaction databases

STRINGi279808.SH1608

Structurei

3D structure databases

ProteinModelPortaliQ4L608
SMRiQ4L608
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C6V Bacteria
COG0578 LUCA
HOGENOMiHOG000004812
KOiK00111
OMAiVPYYWVG
OrthoDBiPOG091H04DP

Family and domain databases

Gene3Di1.10.8.870, 1 hit
3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR031656 DAO_C
IPR038299 DAO_C_sf
IPR006076 FAD-dep_OxRdtase
IPR036188 FAD/NAD-bd_sf
IPR000447 G3P_DH_FAD-dep
PANTHERiPTHR11985 PTHR11985, 1 hit
PfamiView protein in Pfam
PF01266 DAO, 1 hit
PF16901 DAO_C, 1 hit
PRINTSiPR01001 FADG3PDH
SUPFAMiSSF51905 SSF51905, 1 hit
PROSITEiView protein in PROSITE
PS00977 FAD_G3PDH_1, 1 hit
PS00978 FAD_G3PDH_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q4L608-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSTLNREV IKKNLQNEEY DVVIIGGGIT GAGIALDASQ RGMKVALVEM
60 70 80 90 100
QDFAQGTSSR STKLVHGGLR YLKQAQIKVV AETGKERAIV YENGPHVTTP
110 120 130 140 150
EWMLLPMHKG GTFGKFTTNL GLTAYDRLAG VKKYERKKML SKKQTLNKEP
160 170 180 190 200
LVKKDGLKGG GYYVEYRTDD ARLTIEVMKR AEENGAEILN HTKSTDFIYD
210 220 230 240 250
SKSKVRGIEV QDLLTGEMYE INAKKVINAA GPWVDEVRKK DYTRNNKQLR
260 270 280 290 300
LTKGVHVVID QSKFPLRQAV YFDTEKDGRM IFAIPREGKA YVGTTDTFYD
310 320 330 340 350
NDKTKPLTTQ EDRDYLIDAI NYMFPDVNVK DEDIESTWAG VRPLILEDGK
360 370 380 390 400
DPSEISRKDE IWEGKSGLLT IAGGKLTGYR HMALEIVDLL AKRLKQEYKL
410 420 430 440 450
TFAECKTKHT PISGGDVGGS ANFESFVERK VEEGKAIGLQ ADVAKRLASK
460 470 480 490 500
YGSNVDKLYN IAQIAQDKDL KLPLELYVEL VYSVQNEMVF KPTDFLIRRS
510 520 530 540 550
GKLYFNINEV KQYKDAVVEE LAKLLNYTQS QQNEFTKEIN IAIEEATRGN

EQLAVLK
Length:557
Mass (Da):62,821
Last modified:August 2, 2005 - v1
Checksum:i0856390DC2F7AB13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA Translation: BAE04917.1
RefSeqiWP_011275898.1, NC_007168.1

Genome annotation databases

EnsemblBacteriaiBAE04917; BAE04917; SH1608
GeneIDi24246626
KEGGisha:SH1608

Similar proteinsi

Entry informationi

Entry nameiGLPD_STAHJ
AccessioniPrimary (citable) accession number: Q4L608
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: August 2, 2005
Last modified: April 25, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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