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Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

Cofactori

FADUniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 14FADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandFAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
Gene namesi
Name:trmFOUniRule annotation
Synonyms:gid
Ordered Locus Names:SH1663
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000543 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001172671 – 435Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOAdd BLAST435

Interactioni

Protein-protein interaction databases

STRINGi279808.SH1663.

Structurei

3D structure databases

ProteinModelPortaliQ4L5V3.
SMRiQ4L5V3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QXI. Bacteria.
COG1206. LUCA.
HOGENOMiHOG000252054.
KOiK04094.
OMAiRFGPMKP.
OrthoDBiPOG091H00B3.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
HAMAPiMF_01037. TrmFO. 1 hit.
InterProiView protein in InterPro
IPR023753. FAD/NAD-binding_dom.
IPR002218. MnmG-rel.
IPR020595. MnmG-rel_CS.
IPR004417. TrmFO.
PANTHERiPTHR11806. PTHR11806. 1 hit.
PTHR11806:SF5. PTHR11806:SF5. 1 hit.
PfamiView protein in Pfam
PF01134. GIDA. 1 hit.
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.
PROSITEiView protein in PROSITE
PS01281. GIDA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4L5V3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQTVNIVGA GLAGSEAAYQ LAQRGIKVNL IEMRPVKQTP AHHTDKFAEL
60 70 80 90 100
VCSNSLRGNA LTNGVGVLKE EMRRLDSLII SAADKARVPA GGALAVDRHD
110 120 130 140 150
FSGYITETLR NHPNVTVINE EINSIPEGYT IIATGPLTTE NLAKEIVDIT
160 170 180 190 200
GKDQLYFYDA AAPIIEKESI DMDKVYLKSR YDKGEAAYLN CPMTEEEFNR
210 220 230 240 250
FYDAVLEAEV APTNEFEKEK YFEGCMPFEV MAERGRKTLL FGPMKPVGLE
260 270 280 290 300
DPKTGKRPFA VVQLRQDDAA GTLYNIVGFQ THLKWGAQKE VIRLIPGLEN
310 320 330 340 350
VDIVRYGVMH RNTFINSPDV LNEKYELIKE DRIQFAGQMT GVEGYVESAA
360 370 380 390 400
SGLVAGINLA HKLLDKGEVI FPRETMIGSM AYYISHAKNE KNFQPMNANF
410 420 430
GLLPSLEKRI KDKKERYEAQ ANRALEYLEN YKKTL
Length:435
Mass (Da):48,657
Last modified:August 2, 2005 - v1
Checksum:iB7F97F800C05F9D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA. Translation: BAE04972.1.
RefSeqiWP_011275949.1. NC_007168.1.

Genome annotation databases

EnsemblBacteriaiBAE04972; BAE04972; SH1663.
GeneIDi24248070.
KEGGisha:SH1663.

Similar proteinsi

Entry informationi

Entry nameiTRMFO_STAHJ
AccessioniPrimary (citable) accession number: Q4L5V3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: August 2, 2005
Last modified: August 30, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families