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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylformylglycinamidine synthase subunit PurS (purS), Phosphoribosylformylglycinamidine synthase subunit PurQ (purQ), Phosphoribosylformylglycinamidine synthase subunit PurL (purL)
  2. Phosphoribosylformylglycinamidine cyclo-ligase (purM)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00129

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:SH1886
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000543 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001482531 – 343Phosphoribosylformylglycinamidine cyclo-ligaseAdd BLAST343

Proteomic databases

PRIDEiQ4L580

Interactioni

Protein-protein interaction databases

STRINGi279808.SH1886

Structurei

3D structure databases

ProteinModelPortaliQ4L580
SMRiQ4L580
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CXB Bacteria
COG0150 LUCA
HOGENOMiHOG000229090
KOiK01933
OMAiNHCVNDI
OrthoDBiPOG091H0128

Family and domain databases

CDDicd02196 PurM, 1 hit
Gene3Di3.30.1330.10, 1 hit
3.90.650.10, 1 hit
HAMAPiMF_00741 AIRS, 1 hit
InterProiView protein in InterPro
IPR010918 PurM-like_C_dom
IPR036676 PurM-like_C_sf
IPR016188 PurM-like_N
IPR036921 PurM-like_N_sf
IPR004733 PurM_cligase
PANTHERiPTHR10520 PTHR10520, 1 hit
PfamiView protein in Pfam
PF00586 AIRS, 1 hit
PF02769 AIRS_C, 1 hit
SUPFAMiSSF55326 SSF55326, 1 hit
SSF56042 SSF56042, 1 hit
TIGRFAMsiTIGR00878 purM, 1 hit

Sequencei

Sequence statusi: Complete.

Q4L580-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKAYEQSGV DIHAGYEAVE RMSSHVKRTM RKEVLGGLGG FGATFDLSQL
60 70 80 90 100
NMKAPVLVSG TDGVGTKLKL AIDNDKHDTI GIDAVAMCVN DILTTGAEPL
110 120 130 140 150
YFLDYIATNK VVPEVIEQIV KGVSDGCEET NTALIGGETA EMGEMYHEGE
160 170 180 190 200
YDLAGFAVGA VEKDDYIDGS AIQEGQAIIG LASNGIHSNG YSLVRKLIKE
210 220 230 240 250
SGIDLNDDFD GRTYLETFLA PTQLYVKPIL ALKKAVQIKG MNHITGGGFY
260 270 280 290 300
ENIPRGLPEG LAANIDTQAF PTPNVFNWLQ QQANIDTKEM YNVFNMGIGF
310 320 330 340
TVIIDKKDVA QTLDILKQEG ISAFEIGEII EDKDTPIHLE GVE
Length:343
Mass (Da):37,146
Last modified:August 2, 2005 - v1
Checksum:iBC5420B09A750CAF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA Translation: BAE05195.1
RefSeqiWP_011276159.1, NC_007168.1

Genome annotation databases

EnsemblBacteriaiBAE05195; BAE05195; SH1886
GeneIDi24248095
KEGGisha:SH1886

Similar proteinsi

Entry informationi

Entry nameiPUR5_STAHJ
AccessioniPrimary (citable) accession number: Q4L580
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: August 2, 2005
Last modified: April 25, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health