Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q4L505 (SPX_STAHJ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Regulatory protein spx
Gene names
Name:spxA
Ordered Locus Names:SH1961
OrganismStaphylococcus haemolyticus (strain JCSC1435) [Complete proteome] [HAMAP]
Taxonomic identifier279808 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacillalesStaphylococcus

Protein attributes

Sequence length131 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress By similarity. HAMAP MF_01132

Subcellular location

Cytoplasm Probable HAMAP MF_01132.

Sequence similarities

Belongs to the ArsC family. Spx subfamily.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentCytoplasm
   DomainRedox-active center
   PTMDisulfide bond
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processnegative regulation of transcription, DNA-dependent

Inferred from electronic annotation. Source: InterPro

transcription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 131131Regulatory protein spx HAMAP MF_01132
PRO_0000162570

Amino acid modifications

Disulfide bond10 ↔ 13Redox-active Potential

Sequences

Sequence LengthMass (Da)Tools
Q4L505 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: 89F9C1FE367979BF

FASTA13115,422
        10         20         30         40         50         60 
MVTLFTSPSC TSCRKAKAWL QEHDIPYTER NIFSEHLTID EIKQILKMTE DGTDEIISTR 

        70         80         90        100        110        120 
SKTYQKLNVD IDSLPLQDLY AIIQDNPGLL RRPIILDEKR LQVGYNEDEI RRFLPRKVRT 

       130 
FQLQEAQRLV D 

« Hide

References

[1]"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species."
Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K.
J. Bacteriol. 187:7292-7308(2005) [PubMed: 16237012] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JCSC1435.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP006716 Genomic DNA. Translation: BAE05270.1.
RefSeqYP_253876.1. NC_007168.1.

3D structure databases

ProteinModelPortalQ4L505.
SMRQ4L505. Positions 1-118.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ4L505.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000044476; EBSTAP00000042927; EBSTAG00000044474.
GeneID3483058.
GenomeReviewsGene locus SH1961 in contig AP006716_GR.
KEGGsha:SH1961.
NMPDRfig|279808.3.peg.2163.
PATRIC19620027. VBIStaHae67511_1934.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1393.
GeneTreeEBGT00050000024542.
HOGENOMHBG734370.
OMAFTERNIF.
ProtClustDBPRK01655.

Enzyme and pathway databases

BioCycSHAE279808:SH1961-MONOMER.

Family and domain databases

HAMAPMF_01132. SpxA.
[Tree]
InterProIPR006660. Arsenate_reductase-like.
IPR012336. Thioredoxin-like_fold.
IPR023731. Tscrpt_reg_Spx.
IPR006504. Tscrpt_reg_Spx/MgsR.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KOK00537.
PfamPF03960. ArsC. 1 hit.
[Graphical view]
SUPFAMSSF52833. Thiordxn-like_fd. 1 hit.
TIGRFAMsTIGR01617. ArsC_related. 1 hit.
PROSITEPS51353. ARSC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSPX_STAHJ
AccessionPrimary (citable) accession number: Q4L505
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: August 2, 2005
Last modified: January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families