Reviewed, UniProtKB/Swiss-Prot Q4L4U5 (DLTA_STAHJ)

Names and origin

Protein names

Recommended name:
    D-alanine--poly(phosphoribitol) ligase subunit 1
    EC=6.1.1.13
Alternative name(s):
    D-alanine-activating enzyme
      Short name=DAE
    D-alanine-D-alanyl carrier protein ligase
      Short name=DCL

Gene names

Name:	dltA
Ordered Locus Names:	SH2021

Organism

Staphylococcus haemolyticus (strain JCSC1435) [Complete proteome] [HAMAP]

Taxonomic identifier

279808 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	485 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp By similarity.
Catalytic activity	ATP + D-alanine + poly(ribitol phosphate) = AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate). HAMAP MF_00593
Pathway	Cell wall biogenesis; lipoteichoic acid biosynthesis. HAMAP MF_00593
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	teichoic acid biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW D-alanine-poly(phosphoribitol) ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 485	485	D-alanine--poly(phosphoribitol) ligase subunit 1 HAMAP MF_00593		PRO_0000213158

Sequences

	Sequence		Length	Mass (Da)
	Q4L4U5-1 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 6724289A0688ABB3	FASTA	485	54,705
	10 20 30 40 50 60 MTDIINLIND FGQSNPERVA VRHKDEELTY QQLMDESSKL AHLLQDNHKP LIVYGHMSPY 70 80 90 100 110 120 MLVGMIGAIK AGCGYVPIDT SVPSERVNMI INKVQPDIIF NTSDTQLNHS NIQELTIQSI 130 140 150 160 170 180 QDSDNPTLFD SQMGLTDVVY TIFTSGSTGE PKGVQIEYAS LIEFAEWMVS LNESEGSQEW 190 200 210 220 230 240 LNQAPFSFDL SVMAIYPCLT SGGTLNLVDK EMINKPKLLN EMLVNTPINA WVSTPSFMEM 250 260 270 280 290 300 CLLLPNLNES SYPSLNHFFF CGEILPHRTA KALLDRYPSA VVYNTYGPTE ATVAVTGIKL 310 320 330 340 350 360 TPEVIEAYNP LPVGVSRPNT SLFTTDEGEL VIKGNSVSLG YLDNKEKTDA VFNFEDGLRI 370 380 390 400 410 420 YHTGDKAIEK DGQWFIQGRI DFQIKLNGYR MELEEIETQL RQSEFVRETV VVPVYKNNKV 430 440 450 460 470 480 IHLIGAVVPT EEVRDDLEMT RQIKSELKSR LPEYMIPRKF VWMKQLPLTS NGKLDRKQVA EDINA

References

[1]

"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species." Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K. J. Bacteriol. 187:7292-7308(2005) [PubMed: 16237012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP006716 Genomic DNA. Translation: BAE05330.1.
RefSeq	YP_253936.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3482302.
GenomeReviews	Gene locus SH2021 in contig AP006716_GR.
KEGG	sha:SH2021.
NMPDR	fig|279808.3.peg.2392.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4L4U5.
OMA	Q4L4U5. THIKHEL.
Enzyme and pathway databases
BioCyc	SHAE279808:SH2021-MON.
Family and domain databases
HAMAP	MF_00593. [Tree]
InterPro	IPR010071. AA_adenyl_domain. IPR000873. AMP-dep_Synth/Lig. IPR010072. D_ala_DACP_lig. [Graphical view]
PANTHER	PTHR11968:SF34. D_ala_DACP_lig. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. [Graphical view]
TIGRFAMs	TIGR01733. AA-adenyl-dom. 1 hit. TIGR01734. D-ala-DACP-lig. 1 hit.
PROSITE	PS00455. AMP_BINDING. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DLTA_STAHJ

Accession

Primary (citable) accession number: Q4L4U5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	August 2, 2005
Last modified:	June 16, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)