Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

3-dehydroquinate dehydratase

Gene

aroD

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.UniRule annotation

Catalytic activityi

3-dehydroquinate = 3-dehydroshikimate + H2O.UniRule annotation

Pathwayi: chorismate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (aroD)
  4. Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase (aroK)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei703-dehydroquinateUniRule annotation1
Active sitei133Proton donor/acceptorUniRule annotation1
Active sitei160Schiff-base intermediate with substrateUniRule annotation1
Binding sitei2023-dehydroquinateUniRule annotation1
Binding sitei2253-dehydroquinateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00053; UER00086.

Names & Taxonomyi

Protein namesi
Recommended name:
3-dehydroquinate dehydrataseUniRule annotation (EC:4.2.1.10UniRule annotation)
Short name:
3-dehydroquinaseUniRule annotation
Alternative name(s):
Type I DHQaseUniRule annotation
Type I dehydroquinaseUniRule annotation
Short name:
DHQ1UniRule annotation
Gene namesi
Name:aroDUniRule annotation
Ordered Locus Names:SH2055
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000543 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000431891 – 2413-dehydroquinate dehydrataseAdd BLAST241

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi279808.SH2055.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni35 – 373-dehydroquinate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the type-I 3-dehydroquinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105FF2. Bacteria.
COG0710. LUCA.
HOGENOMiHOG000105514.
KOiK03785.
OMAiCTFGAGE.
OrthoDBiPOG091H02LE.

Family and domain databases

CDDicd00502. DHQase_I. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00214. AroD. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001381. DHquinase_I.
[Graphical view]
PfamiPF01487. DHquinase_I. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01093. aroD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4L4R1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNVEVAATV APNQLLDTLT LDNIKEYSND IDIIELRIDQ WEDRHLELLK
60 70 80 90 100
SNLEQLQELN INANVLVTYR TISQGGKGEM THEAYMTLLK EIIKNHHCQM
110 120 130 140 150
IDIEWDSDFD VFAHRDLINL AHRYNKQVVI SYHNFQETPD IDILKFTYYK
160 170 180 190 200
MNQLNPDYVK IAVMPQDKED VATLLEAVAT SADTLDAKVI GISMSKVGLV
210 220 230 240
SRTAQGVFGG TVSYGCLGEP QAPGQIHVKT LKQQLLFYSN H
Length:241
Mass (Da):27,366
Last modified:August 2, 2005 - v1
Checksum:iE6AA589B23FBD871
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA. Translation: BAE05364.1.
RefSeqiWP_011276319.1. NC_007168.1.

Genome annotation databases

EnsemblBacteriaiBAE05364; BAE05364; SH2055.
GeneIDi24246033.
KEGGisha:SH2055.
PATRICi19620209. VBIStaHae67511_2025.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA. Translation: BAE05364.1.
RefSeqiWP_011276319.1. NC_007168.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi279808.SH2055.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAE05364; BAE05364; SH2055.
GeneIDi24246033.
KEGGisha:SH2055.
PATRICi19620209. VBIStaHae67511_2025.

Phylogenomic databases

eggNOGiENOG4105FF2. Bacteria.
COG0710. LUCA.
HOGENOMiHOG000105514.
KOiK03785.
OMAiCTFGAGE.
OrthoDBiPOG091H02LE.

Enzyme and pathway databases

UniPathwayiUPA00053; UER00086.

Family and domain databases

CDDicd00502. DHQase_I. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00214. AroD. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001381. DHquinase_I.
[Graphical view]
PfamiPF01487. DHquinase_I. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01093. aroD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAROD_STAHJ
AccessioniPrimary (citable) accession number: Q4L4R1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 2, 2005
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.