Q4L4R1 (AROD_STAHJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10

Alternative name(s):
Type I DHQase

Gene names

Name:	aroD
Ordered Locus Names:	SH2055

Organism

Staphylococcus haemolyticus (strain JCSC1435) [Complete proteome] [HAMAP]

Taxonomic identifier

279808 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	241 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214
Subunit structure	Homodimer By similarity. HAMAP MF_00214
Sequence similarities	Belongs to the type-I 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 241	241	3-dehydroquinate dehydratase HAMAP MF_00214		PRO_1000043189
Sites
	Active site	133	1	Proton acceptor By similarity
	Active site	160	1	Schiff-base intermediate with substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4L4R1 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: E6AA589B23FBD871	FASTA	241	27,366
	10 20 30 40 50 60 MTNVEVAATV APNQLLDTLT LDNIKEYSND IDIIELRIDQ WEDRHLELLK SNLEQLQELN 70 80 90 100 110 120 INANVLVTYR TISQGGKGEM THEAYMTLLK EIIKNHHCQM IDIEWDSDFD VFAHRDLINL 130 140 150 160 170 180 AHRYNKQVVI SYHNFQETPD IDILKFTYYK MNQLNPDYVK IAVMPQDKED VATLLEAVAT 190 200 210 220 230 240 SADTLDAKVI GISMSKVGLV SRTAQGVFGG TVSYGCLGEP QAPGQIHVKT LKQQLLFYSN H

References

[1]

"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species." Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K. J. Bacteriol. 187:7292-7308(2005) [PubMed: 16237012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JCSC1435.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006716 Genomic DNA. Translation: BAE05364.1.
RefSeq	YP_253970.1. NC_007168.1.
3D structure databases
HSSP	HSSP built from PDB template 1L9W based on UniProtKB P24670.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4L4R1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000046348; EBSTAP00000044799; EBSTAG00000046345.
GeneID	3483000.
GenomeReviews	Gene locus SH2055 in contig AP006716_GR.
KEGG	sha:SH2055.
NMPDR	fig|279808.3.peg.2521.
PATRIC	19620209. VBIStaHae67511_2025.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0710.
GeneTree	EBGT00050000025297.
HOGENOM	HBG732926.
OMA	IAKIAVM.
PhylomeDB	Q4L4R1.
ProtClustDB	PRK13575.
Enzyme and pathway databases
BioCyc	SHAE279808:SH2055-MONOMER.
Family and domain databases
HAMAP	MF_00214. AroD. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR001381. DHquinase_I. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K03785.
Pfam	PF01487. DHquinase_I. 1 hit. [Graphical view]
TIGRFAMs	TIGR01093. AroD. 1 hit.
PROSITE	PS01028. DEHYDROQUINASE_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROD_STAHJ

Accession

Primary (citable) accession number: Q4L4R1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 2, 2005
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program