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Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei59Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processDNA damage, DNA repair

Enzyme and pathway databases

BioCyciSHAE279808:G1G27-2371-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDGUniRule annotation
Gene namesi
Name:ungUniRule annotation
Ordered Locus Names:SH2411
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000543 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000099471 – 219Uracil-DNA glycosylaseAdd BLAST219

Interactioni

Protein-protein interaction databases

STRINGi279808.SH2411

Structurei

3D structure databases

ProteinModelPortaliQ4L3Q7
SMRiQ4L3Q7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D5S Bacteria
COG0692 LUCA
HOGENOMiHOG000229528
KOiK03648
OMAiQANGLCF
OrthoDBiPOG091H03VL

Family and domain databases

CDDicd10027 UDG_F1, 1 hit
Gene3Di3.40.470.101 hit
HAMAPiMF_00148 UDG, 1 hit
InterProiView protein in InterPro
IPR002043 UDG_fam1
IPR018085 Ura-DNA_Glyclase_AS
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264 PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SMARTiView protein in SMART
SM00986 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00628 ung, 1 hit
PROSITEiView protein in PROSITE
PS00130 U_DNA_GLYCOSYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q4L3Q7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEWSEIFHDI TERHDFKEMH DFLEKEYTTQ TIYPDRDNIY QAFDLTPFED
60 70 80 90 100
VKVVILGQDP YHGPNQAHGL AFSVQPSAKF PPSLRNMYQE LEDDIGCHRT
110 120 130 140 150
SPHLQDWARE GVLLLNTVLT VRQGQAHSHK DIGWETFTDE VIQAISKYRD
160 170 180 190 200
DVVFILWGKP AQQKIKLIDT SKHYIIKSPH PSPLSAYRGF FGSKPYSKTN
210
DYLVSKGKSP INWCENGED
Length:219
Mass (Da):25,384
Last modified:August 2, 2005 - v1
Checksum:iA50EB149D3B2312A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA Translation: BAE05720.1
RefSeqiWP_011276666.1, NC_007168.1

Genome annotation databases

EnsemblBacteriaiBAE05720; BAE05720; SH2411
GeneIDi24248193
KEGGisha:SH2411

Similar proteinsi

Entry informationi

Entry nameiUNG_STAHJ
AccessioniPrimary (citable) accession number: Q4L3Q7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 2, 2005
Last modified: April 25, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome