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Q4L3C1

- SLE1_STAHJ

UniProt

Q4L3C1 - SLE1_STAHJ

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Protein

N-acetylmuramoyl-L-alanine amidase sle1

Gene

sle1

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Peptidoglycan hydrolase involved in the splitting of the septum during cell division.By similarity

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

GO - Molecular functioni

  1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC

GO - Biological processi

  1. barrier septum assembly Source: UniProtKB-KW
  2. cell wall organization Source: UniProtKB-KW
  3. cytolysis Source: UniProtKB-KW
  4. defense response to bacterium Source: UniProtKB-KW
  5. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Hydrolase

Keywords - Biological processi

Cell cycle, Cell division, Cell wall biogenesis/degradation, Septation, Virulence

Enzyme and pathway databases

BioCyciSHAE279808:GJX7-2622-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylmuramoyl-L-alanine amidase sle1 (EC:3.5.1.28)
Gene namesi
Name:sle1
Synonyms:aaa
Ordered Locus Names:SH2547
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000543: Chromosome

Subcellular locationi

Secreted By similarity. Cell surface By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 329303N-acetylmuramoyl-L-alanine amidase sle1PRO_0000231629Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279808.SH2547.

Structurei

3D structure databases

ProteinModelPortaliQ4L3C1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati30 – 7243LysM 1Add
BLAST
Repeati90 – 13243LysM 2Add
BLAST
Repeati154 – 19643LysM 3Add
BLAST
Domaini205 – 329125Peptidase C51PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 LysM repeats.Curated
Contains 1 peptidase C51 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG3942.
HOGENOMiHOG000279823.
OMAiEMNYSAS.
OrthoDBiEOG6GTZPF.

Family and domain databases

Gene3Di3.10.350.10. 3 hits.
InterProiIPR007921. CHAP_dom.
IPR018392. LysM_dom.
[Graphical view]
PfamiPF05257. CHAP. 1 hit.
PF01476. LysM. 3 hits.
[Graphical view]
SMARTiSM00257. LysM. 3 hits.
[Graphical view]
SUPFAMiSSF54106. SSF54106. 3 hits.
PROSITEiPS50911. CHAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4L3C1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKKILATAV LGTGALSTLF AHQAEASTTH TVRSGESLWS ISHHYGITVS
60 70 80 90 100
KLKSLNGLSS NLIFPNQVLK VSGSSNYSSR SNYGNSSSTY TVRAGDSLSS
110 120 130 140 150
IASRYGTTYR HIMNLNGLNS FLIFPGQQLK VSGSVSSNSH SSYNSNSGGS
160 170 180 190 200
SSTYTVRYGD SLSSIASRYG TTYQHIMRLN GLNNFFIYPG QKLRVSGSAS
210 220 230 240 250
SNTYSTRSAQ STYYSSPVFN HRNLYDWGQC TWHVFNRRAA IGKGISTYWW
260 270 280 290 300
NANNWDNAAA RDGYRIDGNP TVGSIAQSDA GYYGHVAFVE RVNSNGSILV
310 320
SEMNFSASPG ILTYRTIPAY QVRNYKFIH
Length:329
Mass (Da):36,019
Last modified:August 2, 2005 - v1
Checksum:i8C1645D548459455
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006716 Genomic DNA. Translation: BAE05856.1.
RefSeqiYP_254462.1. NC_007168.1.

Genome annotation databases

EnsemblBacteriaiBAE05856; BAE05856; SH2547.
GeneIDi3482633.
KEGGisha:SH2547.
PATRICi19621195. VBIStaHae67511_2500.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006716 Genomic DNA. Translation: BAE05856.1 .
RefSeqi YP_254462.1. NC_007168.1.

3D structure databases

ProteinModelPortali Q4L3C1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 279808.SH2547.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE05856 ; BAE05856 ; SH2547 .
GeneIDi 3482633.
KEGGi sha:SH2547.
PATRICi 19621195. VBIStaHae67511_2500.

Phylogenomic databases

eggNOGi COG3942.
HOGENOMi HOG000279823.
OMAi EMNYSAS.
OrthoDBi EOG6GTZPF.

Enzyme and pathway databases

BioCyci SHAE279808:GJX7-2622-MONOMER.

Family and domain databases

Gene3Di 3.10.350.10. 3 hits.
InterProi IPR007921. CHAP_dom.
IPR018392. LysM_dom.
[Graphical view ]
Pfami PF05257. CHAP. 1 hit.
PF01476. LysM. 3 hits.
[Graphical view ]
SMARTi SM00257. LysM. 3 hits.
[Graphical view ]
SUPFAMi SSF54106. SSF54106. 3 hits.
PROSITEi PS50911. CHAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species."
    Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K.
    J. Bacteriol. 187:7292-7308(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCSC1435.

Entry informationi

Entry nameiSLE1_STAHJ
AccessioniPrimary (citable) accession number: Q4L3C1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: August 2, 2005
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3