Q4L3C1 (SLE1_STAHJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetylmuramoyl-L-alanine amidase sle1
EC=3.5.1.28

Gene names

Name:	sle1
Synonyms:	aaa
Ordered Locus Names:	SH2547

Organism

Staphylococcus haemolyticus (strain JCSC1435) [Complete proteome] [HAMAP]

Taxonomic identifier

279808 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus haemolyticus

Protein attributes

Sequence length	329 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Peptidoglycan hydrolase involved in the splitting of the septum during cell division By similarity.
Catalytic activity	Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.
Subcellular location	Secreted By similarity. Cell surface By similarity.
Sequence similarities	Contains 3 LysM repeats. Contains 1 peptidase C51 domain.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell wall biogenesis/degradation Septation Virulence
Cellular component	Secreted
Domain	Repeat Signal
Molecular function	Antimicrobial Bacteriolytic enzyme Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	barrier septum assembly Inferred from electronic annotation. Source: UniProtKB-KW cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cell surface Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	N-acetylmuramoyl-L-alanine amidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 329	303	N-acetylmuramoyl-L-alanine amidase sle1		PRO_0000231629
Regions
	Repeat	30 – 72	43	LysM 1
	Repeat	90 – 132	43	LysM 2
	Repeat	154 – 196	43	LysM 3
	Domain	205 – 329	125	Peptidase C51

Sequences

	Sequence		Length	Mass (Da)
	Q4L3C1 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 8C1645D548459455	FASTA	329	36,019
	10 20 30 40 50 60 MNKKILATAV LGTGALSTLF AHQAEASTTH TVRSGESLWS ISHHYGITVS KLKSLNGLSS 70 80 90 100 110 120 NLIFPNQVLK VSGSSNYSSR SNYGNSSSTY TVRAGDSLSS IASRYGTTYR HIMNLNGLNS 130 140 150 160 170 180 FLIFPGQQLK VSGSVSSNSH SSYNSNSGGS SSTYTVRYGD SLSSIASRYG TTYQHIMRLN 190 200 210 220 230 240 GLNNFFIYPG QKLRVSGSAS SNTYSTRSAQ STYYSSPVFN HRNLYDWGQC TWHVFNRRAA 250 260 270 280 290 300 IGKGISTYWW NANNWDNAAA RDGYRIDGNP TVGSIAQSDA GYYGHVAFVE RVNSNGSILV 310 320 SEMNFSASPG ILTYRTIPAY QVRNYKFIH

References

[1]

"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species." Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K. J. Bacteriol. 187:7292-7308(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JCSC1435.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006716 Genomic DNA. Translation: BAE05856.1.
RefSeq	YP_254462.1. NC_007168.1.
3D structure databases
ProteinModelPortal	Q4L3C1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAE05856; BAE05856; SH2547.
GeneID	3482633.
KEGG	sha:SH2547.
PATRIC	19621195. VBIStaHae67511_2500.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3942.
HOGENOM	HOG000279823.
OMA	LIASKYN.
ProtClustDB	CLSK884669.
Enzyme and pathway databases
BioCyc	SHAE279808:GJX7-2622-MONOMER.
Family and domain databases
InterPro	IPR007921. CHAP. IPR018392. Peptidoglycan-bd_lysin. IPR002482. Peptidoglycan-bd_Lysin_subgr. [Graphical view]
Pfam	PF05257. CHAP. 1 hit. PF01476. LysM. 3 hits. [Graphical view]
SMART	SM00257. LysM. 3 hits. [Graphical view]
PROSITE	PS50911. CHAP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SLE1_STAHJ

Accession

Primary (citable) accession number: Q4L3C1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	August 2, 2005
Last modified:	May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program