ahpC

Functionⁱ

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.By similarity

Miscellaneous

The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by AhpF.By similarity

Catalytic activityⁱ

2 R'-SH + ROOH = R'-S-S-R' + H₂O + ROH.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	49	Cysteine sulfenic acid (-SOH) intermediateBy similarity		1

GO - Molecular functionⁱ

peroxidase activity Source: UniProtKB-KW
peroxiredoxin activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell redox homeostasis Source: InterPro
response to oxidative stress Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Antioxidant, Oxidoreductase, Peroxidase

Molecular function

Antioxidant, Oxidoreductase, Peroxidase

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alkyl hydroperoxide reductase C (EC:1.11.1.15) Alternative name(s): Peroxiredoxin Thioredoxin peroxidase
Gene namesⁱ	Name:ahpC Ordered Locus Names:SH2592
Organismⁱ	Staphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifierⁱ	279808 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus haemolyticus
Proteomesⁱ	UP000000543 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:P0AE08 (AHPC_ECOLI)

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000279761	1 – 189	Alkyl hydroperoxide reductase CAdd BLAST		189

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	49	Interchain (with C-168); in linked formBy similarity
Disulfide bondⁱ	168	Interchain (with C-49); in linked formBy similarity

Keywords - PTMⁱ

Disulfide bond

Interactionⁱ

Subunit structureⁱ

Homodimer; disulfide-linked, upon oxidation. 5 homodimers assemble to form a ring-like decamer.By similarity

Protein-protein interaction databases

STRINGⁱ	279808.SH2592

STRINGⁱ

279808.SH2592

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q4L376
SMRⁱ	Q4L376
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	2 – 159	ThioredoxinPROSITE-ProRule annotationAdd BLAST		158

Sequence similaritiesⁱ

Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.Curated

Keywords - Domainⁱ

Redox-active center

Phylogenomic databases

eggNOGⁱ	ENOG4105D3R Bacteria COG0450 LUCA
HOGENOMⁱ	HOG000022343
KEGG Orthology (KO) More...KOⁱ	K03386
OMAⁱ	CPANWEE
Database of Orthologous Groups More...OrthoDBⁱ	POG091H026G

Family and domain databases

InterProⁱ	View protein in InterPro IPR017559 AhpC IPR000866 AhpC/TSA IPR024706 Peroxiredoxin_AhpC-typ IPR019479 Peroxiredoxin_C IPR036249 Thioredoxin-like_sf IPR013766 Thioredoxin_domain
PANTHERⁱ	PTHR10681:SF121 PTHR10681:SF121, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10417 1-cysPrx_C, 1 hit PF00578 AhpC-TSA, 1 hit
PIRSFⁱ	PIRSF000239 AHPC, 1 hit
SUPFAMⁱ	SSF52833 SSF52833, 1 hit
TIGRFAMsⁱ	TIGR03137 AhpC, 1 hit
PROSITEⁱ	View protein in PROSITE PS51352 THIOREDOXIN_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q4L376-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSLINKEILP FIAQAYDPKK DEFKEVSQDD LKGSWSVVCF YPADFSFVCP 
        60         70         80         90        100
TELEDLQNQY DKLQDLGVNV FSVSTDTHFV HKAWHDHSDA ISKIQYQMIG 
       110        120        130        140        150
DPSQTITRNF DVLDEEAGLA QRGTFIIDPD GVVQAAEINA DGIGRDASTL 
       160        170        180 
VNKIKAAQYV RQHPGEVCPA KWEEGSESLQ PGLDLVGKI

Length:189

Mass (Da):21,047

Last modified:August 2, 2005 - v1

Checksum:ⁱ2A1F87D0EFB461AF

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AP006716 Genomic DNA Translation: BAE05901.1
NCBI Reference Sequences More...RefSeqⁱ	WP_011276838.1, NC_007168.1

Genome annotation databases

EnsemblBacteriaⁱ	BAE05901; BAE05901; SH2592
GeneIDⁱ	24246502
KEGGⁱ	sha:SH2592

Protein	Similar proteins		Species	Score	Length
Q4L376	Peroxiredoxin		STAHA		189
Peroxiredoxin		Staphylococcus sp. HMSC14D01		189

Protein	Similar proteins		Species	Score	Length
Q4L376	Alkyl hydroperoxide reductase C		STAES		189
UPI000BE029B3		LISMN		168
Alkyl hydroperoxide reductase C		STAEQ		189
Peroxiredoxin		Staphylococcus epidermidis M23864:W2(grey)		189
Peroxiredoxin (Fragment)		PAEMA		67
+48

Protein	Similar proteins		Species	Score	Length
Q4L376	Alkyl hydroperoxide reductase C		ECO57		187
Alkyl hydroperoxide reductase C		ECOL6		187
Alkyl hydroperoxide reductase C	)	ECOLI		187
Alkyl hydroperoxide reductase C		SHIFL		187
AhpC-TSA multi-domain protein		Escherichia coli NCCP15648		187
+7550

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AP006716 Genomic DNA Translation: BAE05901.1
NCBI Reference Sequences More...RefSeqⁱ	WP_011276838.1, NC_007168.1

3D structure databases

ProteinModelPortalⁱ	Q4L376
SMRⁱ	Q4L376
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	279808.SH2592

STRINGⁱ

279808.SH2592

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	BAE05901; BAE05901; SH2592
GeneIDⁱ	24246502
KEGGⁱ	sha:SH2592

Phylogenomic databases

eggNOGⁱ	ENOG4105D3R Bacteria COG0450 LUCA
HOGENOMⁱ	HOG000022343
KEGG Orthology (KO) More...KOⁱ	K03386
OMAⁱ	CPANWEE
Database of Orthologous Groups More...OrthoDBⁱ	POG091H026G

Family and domain databases

InterProⁱ	View protein in InterPro IPR017559 AhpC IPR000866 AhpC/TSA IPR024706 Peroxiredoxin_AhpC-typ IPR019479 Peroxiredoxin_C IPR036249 Thioredoxin-like_sf IPR013766 Thioredoxin_domain
PANTHERⁱ	PTHR10681:SF121 PTHR10681:SF121, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10417 1-cysPrx_C, 1 hit PF00578 AhpC-TSA, 1 hit
PIRSFⁱ	PIRSF000239 AHPC, 1 hit
SUPFAMⁱ	SSF52833 SSF52833, 1 hit
TIGRFAMsⁱ	TIGR03137 AhpC, 1 hit
PROSITEⁱ	View protein in PROSITE PS51352 THIOREDOXIN_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AHPC_STAHJ
Accessionⁱ	Q4L376Primary (citable) accession number: Q4L376
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 6, 2007
	Last sequence update:	August 2, 2005
	Last modified:	April 25, 2018
	This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

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UniProtKB - Q4L376 (AHPC_STAHJ)

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Alkyl hydroperoxide reductase C

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ