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Protein

Alkyl hydroperoxide reductase C

Gene

ahpC

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.By similarity

Miscellaneous

The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by AhpF.By similarity

Catalytic activityi

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei49Cysteine sulfenic acid (-SOH) intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntioxidant, Oxidoreductase, Peroxidase

Names & Taxonomyi

Protein namesi
Recommended name:
Alkyl hydroperoxide reductase C (EC:1.11.1.15)
Alternative name(s):
Peroxiredoxin
Thioredoxin peroxidase
Gene namesi
Name:ahpC
Ordered Locus Names:SH2592
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000543 Componenti: Chromosome

Subcellular locationi

Q4L376:
  • Cytoplasm By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002797611 – 189Alkyl hydroperoxide reductase CAdd BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49Interchain (with C-168); in linked formBy similarity
Disulfide bondi168Interchain (with C-49); in linked formBy similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Homodimer; disulfide-linked, upon oxidation. 5 homodimers assemble to form a ring-like decamer.By similarity

Protein-protein interaction databases

STRINGi279808.SH2592.

Structurei

3D structure databases

ProteinModelPortaliQ4L376.
SMRiQ4L376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 159ThioredoxinPROSITE-ProRule annotationAdd BLAST158

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4105D3R. Bacteria.
COG0450. LUCA.
HOGENOMiHOG000022343.
KOiK03386.
OMAiCPANWEE.
OrthoDBiPOG091H026G.

Family and domain databases

InterProiView protein in InterPro
IPR017559. AhpC.
IPR000866. AhpC/TSA.
IPR024706. Peroxiredoxin_AhpC-typ.
IPR019479. Peroxiredoxin_C.
IPR036249. Thioredoxin-like_sf.
IPR013766. Thioredoxin_domain.
PANTHERiPTHR10681:SF121. PTHR10681:SF121. 1 hit.
PfamiView protein in Pfam
PF10417. 1-cysPrx_C. 1 hit.
PF00578. AhpC-TSA. 1 hit.
PIRSFiPIRSF000239. AHPC. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR03137. AhpC. 1 hit.
PROSITEiView protein in PROSITE
PS51352. THIOREDOXIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4L376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLINKEILP FIAQAYDPKK DEFKEVSQDD LKGSWSVVCF YPADFSFVCP
60 70 80 90 100
TELEDLQNQY DKLQDLGVNV FSVSTDTHFV HKAWHDHSDA ISKIQYQMIG
110 120 130 140 150
DPSQTITRNF DVLDEEAGLA QRGTFIIDPD GVVQAAEINA DGIGRDASTL
160 170 180
VNKIKAAQYV RQHPGEVCPA KWEEGSESLQ PGLDLVGKI
Length:189
Mass (Da):21,047
Last modified:August 2, 2005 - v1
Checksum:i2A1F87D0EFB461AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA. Translation: BAE05901.1.
RefSeqiWP_011276838.1. NC_007168.1.

Genome annotation databases

EnsemblBacteriaiBAE05901; BAE05901; SH2592.
GeneIDi24246502.
KEGGisha:SH2592.

Similar proteinsi

Entry informationi

Entry nameiAHPC_STAHJ
AccessioniPrimary (citable) accession number: Q4L376
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: August 2, 2005
Last modified: October 25, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families