Reviewed, UniProtKB/Swiss-Prot Q4L376 (AHPC_STAHJ)

Names and origin

Protein names

Recommended name:
    Alkyl hydroperoxide reductase subunit C
    EC=1.11.1.15
Alternative name(s):
    Peroxiredoxin
    Thioredoxin peroxidase

Gene names

Name:	ahpC
Ordered Locus Names:	SH2592

Organism

Staphylococcus haemolyticus (strain JCSC1435) [Complete proteome] [HAMAP]

Taxonomic identifier

279808 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Directly reduces organic hydroperoxides in its reduced dithiol form By similarity.
Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.
Subunit structure	Homodimer; disulfide-linked, upon oxidation By similarity.
Post-translational modification	The Cys-49-SH group is the primary site of oxidation by H2O2, and the oxidized Cys-49 (probably Cys-SOH) rapidly reacts with Cys-168-SH of the other subunit to form an intermolecular disulfide. This disulfide is subsequently reduced by thioredoxin By similarity.
Sequence similarities	Belongs to the ahpC/TSA family. Contains 1 thioredoxin domain.

Ontologies

Keywords
Domain	Redox-active center
Molecular function	Antioxidant Oxidoreductase Peroxidase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 189	189	Alkyl hydroperoxide reductase subunit C		PRO_0000279761
Regions
	Domain	2 – 159	158	Thioredoxin
Sites
	Active site	49	1	Cysteine sulfenic acid (-SOH) intermediate By similarity
Amino acid modifications
	Disulfide bond	49		Interchain (with C-168); in linked form By similarity
	Disulfide bond	168		Interchain (with C-49); in linked form By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4L376-1 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 2A1F87D0EFB461AF	FASTA	189	21,047
	10 20 30 40 50 60 MSLINKEILP FIAQAYDPKK DEFKEVSQDD LKGSWSVVCF YPADFSFVCP TELEDLQNQY 70 80 90 100 110 120 DKLQDLGVNV FSVSTDTHFV HKAWHDHSDA ISKIQYQMIG DPSQTITRNF DVLDEEAGLA 130 140 150 160 170 180 QRGTFIIDPD GVVQAAEINA DGIGRDASTL VNKIKAAQYV RQHPGEVCPA KWEEGSESLQ PGLDLVGKI

References

[1]

"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species." Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K. J. Bacteriol. 187:7292-7308(2005) [PubMed: 16237012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP006716 Genomic DNA. Translation: BAE05901.1.
RefSeq	YP_254507.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3482442.
GenomeReviews	Gene locus SH2592 in contig AP006716_GR.
KEGG	sha:SH2592.
NMPDR	fig|279808.3.peg.1207.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4L376.
OMA	Q4L376. GDLADHY.
Enzyme and pathway databases
BioCyc	SHAE279808:SH2592-MON.
Family and domain databases
InterPro	IPR000866. Alkyl_hydroperoxide_Rdtase. IPR017559. Peroxiredoxin. IPR017936. Thioredoxin-like. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF00578. AhpC-TSA. 1 hit. [Graphical view]
TIGRFAMs	TIGR03137. AhpC. 1 hit.
PROSITE	PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AHPC_STAHJ

Accession

Primary (citable) accession number: Q4L376

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 6, 2007
Last sequence update:	August 2, 2005
Last modified:	June 16, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)