UniProtKB - Q4L376 (AHPC_STAHJ)
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Protein
Alkyl hydroperoxide reductase C
Gene
ahpC
Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Functioni
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.By similarity
Miscellaneous
The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by AhpF.By similarity
Catalytic activityi
2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 49 | Cysteine sulfenic acid (-SOH) intermediateBy similarity | 1 |
GO - Molecular functioni
- peroxidase activity Source: UniProtKB-KW
- peroxiredoxin activity Source: UniProtKB-EC
GO - Biological processi
- cell redox homeostasis Source: InterPro
- response to oxidative stress Source: InterPro
Keywordsi
Molecular function | Antioxidant, Oxidoreductase, Peroxidase |
Names & Taxonomyi
Protein namesi | Recommended name: Alkyl hydroperoxide reductase C (EC:1.11.1.15)Alternative name(s): Peroxiredoxin Thioredoxin peroxidase |
Gene namesi | Name:ahpC Ordered Locus Names:SH2592 |
Organismi | Staphylococcus haemolyticus (strain JCSC1435) |
Taxonomic identifieri | 279808 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm By similarity
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000279761 | 1 – 189 | Alkyl hydroperoxide reductase CAdd BLAST | 189 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 49 | Interchain (with C-168); in linked formBy similarity | ||
Disulfide bondi | 168 | Interchain (with C-49); in linked formBy similarity |
Keywords - PTMi
Disulfide bondInteractioni
Subunit structurei
Homodimer; disulfide-linked, upon oxidation. 5 homodimers assemble to form a ring-like decamer.By similarity
Protein-protein interaction databases
STRINGi | 279808.SH2592. |
Structurei
3D structure databases
ProteinModelPortali | Q4L376. |
SMRi | Q4L376. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 159 | ThioredoxinPROSITE-ProRule annotationAdd BLAST | 158 |
Sequence similaritiesi
Keywords - Domaini
Redox-active centerPhylogenomic databases
eggNOGi | ENOG4105D3R. Bacteria. COG0450. LUCA. |
HOGENOMi | HOG000022343. |
KOi | K03386. |
OMAi | CPANWEE. |
OrthoDBi | POG091H026G. |
Family and domain databases
InterProi | View protein in InterPro IPR017559. AhpC. IPR000866. AhpC/TSA. IPR024706. Peroxiredoxin_AhpC-typ. IPR019479. Peroxiredoxin_C. IPR036249. Thioredoxin-like_sf. IPR013766. Thioredoxin_domain. |
PANTHERi | PTHR10681:SF121. PTHR10681:SF121. 1 hit. |
Pfami | View protein in Pfam PF10417. 1-cysPrx_C. 1 hit. PF00578. AhpC-TSA. 1 hit. |
PIRSFi | PIRSF000239. AHPC. 1 hit. |
SUPFAMi | SSF52833. SSF52833. 1 hit. |
TIGRFAMsi | TIGR03137. AhpC. 1 hit. |
PROSITEi | View protein in PROSITE PS51352. THIOREDOXIN_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q4L376-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLINKEILP FIAQAYDPKK DEFKEVSQDD LKGSWSVVCF YPADFSFVCP
60 70 80 90 100
TELEDLQNQY DKLQDLGVNV FSVSTDTHFV HKAWHDHSDA ISKIQYQMIG
110 120 130 140 150
DPSQTITRNF DVLDEEAGLA QRGTFIIDPD GVVQAAEINA DGIGRDASTL
160 170 180
VNKIKAAQYV RQHPGEVCPA KWEEGSESLQ PGLDLVGKI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP006716 Genomic DNA. Translation: BAE05901.1. |
RefSeqi | WP_011276838.1. NC_007168.1. |
Genome annotation databases
EnsemblBacteriai | BAE05901; BAE05901; SH2592. |
GeneIDi | 24246502. |
KEGGi | sha:SH2592. |
Similar proteinsi
Entry informationi
Entry namei | AHPC_STAHJ | |
Accessioni | Q4L376Primary (citable) accession number: Q4L376 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 6, 2007 |
Last sequence update: | August 2, 2005 | |
Last modified: | January 31, 2018 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |