ahpC

Functionⁱ

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.By similarity

Miscellaneous

The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by AhpF.By similarity

Catalytic activityⁱ

2 R'-SH + ROOH = R'-S-S-R' + H₂O + ROH.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	49	Cysteine sulfenic acid (-SOH) intermediateBy similarity		1

GO - Molecular functionⁱ

peroxidase activity Source: UniProtKB-KW
peroxiredoxin activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell redox homeostasis Source: InterPro
response to oxidative stress Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Antioxidant, Oxidoreductase, Peroxidase

Molecular function

Antioxidant, Oxidoreductase, Peroxidase

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alkyl hydroperoxide reductase C (EC:1.11.1.15) Alternative name(s): Peroxiredoxin Thioredoxin peroxidase
Gene namesⁱ	Name:ahpC Ordered Locus Names:SH2592
Organismⁱ	Staphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifierⁱ	279808 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus haemolyticus
Proteomesⁱ	UP000000543 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:P0AE08 (AHPC_ECOLI)

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000279761	1 – 189	Alkyl hydroperoxide reductase CAdd BLAST		189

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	49	Interchain (with C-168); in linked formBy similarity
Disulfide bondⁱ	168	Interchain (with C-49); in linked formBy similarity

Keywords - PTMⁱ

Disulfide bond

Interactionⁱ

Subunit structureⁱ

Homodimer; disulfide-linked, upon oxidation. 5 homodimers assemble to form a ring-like decamer.By similarity

Protein-protein interaction databases

STRINGⁱ	279808.SH2592.

STRINGⁱ

279808.SH2592.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q4L376.
SMRⁱ	Q4L376.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	2 – 159	ThioredoxinPROSITE-ProRule annotationAdd BLAST		158

Sequence similaritiesⁱ

Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.Curated

Keywords - Domainⁱ

Redox-active center

Phylogenomic databases

eggNOGⁱ	ENOG4105D3R. Bacteria. COG0450. LUCA.
HOGENOMⁱ	HOG000022343.
KEGG Orthology (KO) More...KOⁱ	K03386.
OMAⁱ	CPANWEE.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H026G.

Family and domain databases

InterProⁱ	View protein in InterPro IPR017559. AhpC. IPR000866. AhpC/TSA. IPR024706. Peroxiredoxin_AhpC-typ. IPR019479. Peroxiredoxin_C. IPR036249. Thioredoxin-like_sf. IPR013766. Thioredoxin_domain.
PANTHERⁱ	PTHR10681:SF121. PTHR10681:SF121. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10417. 1-cysPrx_C. 1 hit. PF00578. AhpC-TSA. 1 hit.
PIRSFⁱ	PIRSF000239. AHPC. 1 hit.
SUPFAMⁱ	SSF52833. SSF52833. 1 hit.
TIGRFAMsⁱ	TIGR03137. AhpC. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51352. THIOREDOXIN_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q4L376-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSLINKEILP FIAQAYDPKK DEFKEVSQDD LKGSWSVVCF YPADFSFVCP 
        60         70         80         90        100
TELEDLQNQY DKLQDLGVNV FSVSTDTHFV HKAWHDHSDA ISKIQYQMIG 
       110        120        130        140        150
DPSQTITRNF DVLDEEAGLA QRGTFIIDPD GVVQAAEINA DGIGRDASTL 
       160        170        180 
VNKIKAAQYV RQHPGEVCPA KWEEGSESLQ PGLDLVGKI

Length:189

Mass (Da):21,047

Last modified:August 2, 2005 - v1

Checksum:ⁱ2A1F87D0EFB461AF

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AP006716 Genomic DNA. Translation: BAE05901.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011276838.1. NC_007168.1.

Genome annotation databases

EnsemblBacteriaⁱ	BAE05901; BAE05901; SH2592.
GeneIDⁱ	24246502.
KEGGⁱ	sha:SH2592.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q4L376	A0A2A1K3Z1 A0A1F2KRN0	Staphylococcus haemolyticus Staphylococcus sp. HMSC14D01	189	UniRef100_Q4L376	Cluster: Alkyl hydroperoxide reductase C	3

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q4L376	Q8CMQ2 A0A2G7IMJ0 UPI000BE029B3 Q5HRY1 A0A2G7JC67 D4FLY9 A0A1R1HF31 A0A255BEJ3 A0A2A1K3Z1 A0A1F2KRN0 +50	Staphylococcus epidermidis (strain ATCC 12228) Staphylococcus epidermidis Listeria monocytogenes Staphylococcus epidermidis (strain ATCC 35984 / RP62A) Staphylococcus epidermidis M23864:W2(grey) Paenibacillus macerans (Bacillus macerans) Pectobacterium carotovorum (Erwinia carotovora) Staphylococcus haemolyticus Staphylococcus sp. HMSC14D01 Staphylococcus sp. HMSC36A02 And more	189	UniRef90_Q8CMQ2	Cluster: Alkyl hydroperoxide reductase C	61

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q4L376	P0AE10 P0AE09 P0AE08 P0AE11 A0A1X3MEK0 A0A024KQS8 A0A222QGY8 W0FVB5 W1BFQ0 A0A2D0PA20 +6295	Escherichia coli O157:H7 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) Escherichia coli (strain K12) Shigella flexneri Escherichia coli E1118 Escherichia coli D6-113.11 Escherichia coli NCCP15648 uncultured bacterium Contig1335 Klebsiella pneumoniae IS22 Escherichia coli O127:H6 And more	187	UniRef50_P0AE10	Cluster: Alkyl hydroperoxide reductase C	6,306

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AP006716 Genomic DNA. Translation: BAE05901.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011276838.1. NC_007168.1.

3D structure databases

ProteinModelPortalⁱ	Q4L376.
SMRⁱ	Q4L376.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	279808.SH2592.

STRINGⁱ

279808.SH2592.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	BAE05901; BAE05901; SH2592.
GeneIDⁱ	24246502.
KEGGⁱ	sha:SH2592.

Phylogenomic databases

eggNOGⁱ	ENOG4105D3R. Bacteria. COG0450. LUCA.
HOGENOMⁱ	HOG000022343.
KEGG Orthology (KO) More...KOⁱ	K03386.
OMAⁱ	CPANWEE.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H026G.

Family and domain databases

InterProⁱ	View protein in InterPro IPR017559. AhpC. IPR000866. AhpC/TSA. IPR024706. Peroxiredoxin_AhpC-typ. IPR019479. Peroxiredoxin_C. IPR036249. Thioredoxin-like_sf. IPR013766. Thioredoxin_domain.
PANTHERⁱ	PTHR10681:SF121. PTHR10681:SF121. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10417. 1-cysPrx_C. 1 hit. PF00578. AhpC-TSA. 1 hit.
PIRSFⁱ	PIRSF000239. AHPC. 1 hit.
SUPFAMⁱ	SSF52833. SSF52833. 1 hit.
TIGRFAMsⁱ	TIGR03137. AhpC. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51352. THIOREDOXIN_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AHPC_STAHJ
Accessionⁱ	Q4L376Primary (citable) accession number: Q4L376
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 6, 2007
	Last sequence update:	August 2, 2005
	Last modified:	January 31, 2018
	This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q4L376 (AHPC_STAHJ)

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Alkyl hydroperoxide reductase C

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

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Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ