Reviewed, UniProtKB/Swiss-Prot Q4L321 (UXUA_STAHJ)

Names and origin

Protein names

Recommended name:
    Mannonate dehydratase
    EC=4.2.1.8
Alternative name(s):
    D-mannonate hydrolase

Gene names

Name:	uxuA
Ordered Locus Names:	SH2647

Organism

Staphylococcus haemolyticus (strain JCSC1435) [Complete proteome] [HAMAP]

Taxonomic identifier

279808 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 348	348	Mannonate dehydratase HAMAP MF_00106		PRO_0000231058

Sequences

	Sequence		Length	Mass (Da)
	Q4L321-1 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 721D45C2A47AA864	FASTA	348	40,078
	10 20 30 40 50 60 MKMTFRWYGK DDPISLEYIK QIPGMKGIVS AIYDVPVGEV WPLDKIKALK QEIEDAGMEL 70 80 90 100 110 120 SVIESVPVHE DIKLGKPTRD KYIENYCETL RNLGQAGIKI VCYNFMPVFD WTRSQLDYRL 130 140 150 160 170 180 DDGSTCLIYD EQDVEKMNPL SGELSLPGWD SSYTKEDLKQ LFDDYKEVDE ETLWDNLNYF 190 200 210 220 230 240 IQKVIPVAEE EDVLMAIHPD DPPWNIFGLP RIITNKENLE RFINLYDSKY NGLTMCSGSL 250 260 270 280 290 300 GADRRNDFVD MLRYFGEKGR VNFVHARNVK LIGDKSFQES AHLSEKGSID MYEVVKTLHS 310 320 330 340 FDYHGPIRPD HGRMIWGETG KPGYGLYDRA LGATYLNGLY EAVSKNNK

References

[1]

"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species." Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K. J. Bacteriol. 187:7292-7308(2005) [PubMed: 16237012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP006716 Genomic DNA. Translation: BAE05956.1.
RefSeq	YP_254562.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q4L321.
Genome annotation databases
GeneID	3481635.
GenomeReviews	Gene locus SH2647 in contig AP006716_GR.
KEGG	sha:SH2647.
NMPDR	fig|279808.3.peg.1467.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4L321.
OMA	IWGETGR.
Enzyme and pathway databases
BioCyc	SHAE279808:SH2647-MON.
Family and domain databases
HAMAP	MF_00106. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
TIGRFAMs	TIGR00695. uxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA_STAHJ

Accession

Primary (citable) accession number: Q4L321

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	August 2, 2005
Last modified:	November 3, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)