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Protein

tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG

Gene

mnmG

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm5s2U34.UniRule annotation

Cofactori

FADUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei123 – 1231FAD; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei178 – 1781FADUniRule annotation
Binding sitei367 – 3671FADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 166FADUniRule annotation
Nucleotide bindingi270 – 28415NADUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciSHAE279808:GJX7-2750-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmGUniRule annotation
Alternative name(s):
Glucose-inhibited division protein AUniRule annotation
Gene namesi
Name:mnmGUniRule annotation
Synonyms:gidAUniRule annotation
Ordered Locus Names:SH2675
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000543 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 625625tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmGPRO_0000117183Add
BLAST

Interactioni

Subunit structurei

Homodimer. Heterotetramer of two MnmE and two MnmG subunits.UniRule annotation

Protein-protein interaction databases

STRINGi279808.SH2675.

Structurei

3D structure databases

ProteinModelPortaliQ4L2Z3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RE5. Bacteria.
COG0445. LUCA.
HOGENOMiHOG000201060.
KOiK03495.
OMAiFRPGYAI.
OrthoDBiPOG091H01O0.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
HAMAPiMF_00129. MnmG_GidA. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR026904. GidA-assoc_3.
IPR004416. MnmG.
IPR002218. MnmG-rel.
IPR020595. MnmG-rel_CS.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
PF13932. GIDA_assoc. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR00136. gidA. 1 hit.
PROSITEiPS01280. GIDA_1. 1 hit.
PS01281. GIDA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4L2Z3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQEYDVIVI GAGHAGIEAG LASARRGAKT LMLTINLDNI AFMPCNPSVG
60 70 80 90 100
GPAKGIVVRE IDALGGQMAK AIDKTHIQMR MLNTGKGPAV RALRAQADKV
110 120 130 140 150
LYQQEMKRVI EDEDNLDIMQ GMVDELIIED NEVKGVRTNI GTEYRAQAVV
160 170 180 190 200
ITTGTFLRGE IILGNMKYSS GPNHQLPSIT LADNLRELGF EVVRFKTGTP
210 220 230 240 250
PRVNAKTIDY SKTEIQPGDD VGRAFSFETT EYILDQLPCW LTYTNDRTHK
260 270 280 290 300
VIDDNLHLSA MYSGMIKGTG PRYCPSIEDK FVRFNDKPRH QLFLEPEGRN
310 320 330 340 350
TNEVYVQGLS TSLPEHVQRQ MLETIPGLEK ADMMRAGYAI EYDAIVPTQL
360 370 380 390 400
WPTLETKMIK NLYTAGQING TSGYEEAAGQ GIMAGINAAG KVLGTGEKIL
410 420 430 440 450
SRSDAYIGVL IDDLVTKGTN EPYRLLTSRA EYRLLLRHDN ADLRLTDVGY
460 470 480 490 500
ELGMISEERY ARFNEKRQQI QDEIQRLTDI RIKPNEHTQS VIEANGGSRL
510 520 530 540 550
KDGILAIDLL RRPEMTYNTI LEILEESHQL PEAVEEQVEI QTKYEGYINK
560 570 580 590 600
SLQQVEKVKR MEEKKIPEDL DYSKVDSLAT EAREKLAEVK PLNIAQASRI
610 620
SGVNPADISI LLVYLEQGKL QRVKN
Length:625
Mass (Da):69,958
Last modified:August 2, 2005 - v1
Checksum:i61E885499A015BD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA. Translation: BAE05984.1.
RefSeqiWP_011276914.1. NC_007168.1.

Genome annotation databases

EnsemblBacteriaiBAE05984; BAE05984; SH2675.
GeneIDi24247884.
KEGGisha:SH2675.
PATRICi19621439. VBIStaHae67511_2622.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA. Translation: BAE05984.1.
RefSeqiWP_011276914.1. NC_007168.1.

3D structure databases

ProteinModelPortaliQ4L2Z3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi279808.SH2675.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAE05984; BAE05984; SH2675.
GeneIDi24247884.
KEGGisha:SH2675.
PATRICi19621439. VBIStaHae67511_2622.

Phylogenomic databases

eggNOGiENOG4107RE5. Bacteria.
COG0445. LUCA.
HOGENOMiHOG000201060.
KOiK03495.
OMAiFRPGYAI.
OrthoDBiPOG091H01O0.

Enzyme and pathway databases

BioCyciSHAE279808:GJX7-2750-MONOMER.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
HAMAPiMF_00129. MnmG_GidA. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR026904. GidA-assoc_3.
IPR004416. MnmG.
IPR002218. MnmG-rel.
IPR020595. MnmG-rel_CS.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
PF13932. GIDA_assoc. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR00136. gidA. 1 hit.
PROSITEiPS01280. GIDA_1. 1 hit.
PS01281. GIDA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMNMG_STAHJ
AccessioniPrimary (citable) accession number: Q4L2Z3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: August 2, 2005
Last modified: September 7, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.