Q4L235 (ACSF4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acyl-CoA synthetase family member 4
EC=6.2.1.-

Alternative name(s):
Aminoadipate-semialdehyde dehydrogenase
Protein NRPS998

Gene names

Name:	AASDH
Synonyms:	ACSF4, U26
ORF Names:	HSPC318

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1098 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA By similarity.
Tissue specificity	Ubiquitously expressed in adult tissues. Ref.1
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family. Contains 1 acyl carrier domain.
Sequence caution	The sequence CAH56482.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	ATP-binding Nucleotide-binding Phosphopantetheine
Molecular function	Ligase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	fatty acid metabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acid-thiol ligase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q4L235-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q4L235-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q4L235-3)

The sequence of this isoform differs from the canonical sequence as follows:
     831-841: CYNGLVYVLKS → KFLNLRFVELN
     842-1098: Missing.

Isoform 4 (identifier: Q4L235-4)

The sequence of this isoform differs from the canonical sequence as follows:
     831-857: CYNGLVYVLKSNSGEKYWMFTTEDAVK → LAVLYQWTNLFIPVYLTIRAKNIFWFP
     858-1098: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1098	1098	Acyl-CoA synthetase family member 4		PRO_0000315803
Regions
	Domain	555 – 626	72	Acyl carrier
	Nucleotide binding	198 – 206	9	ATP By similarity
Sites
	Binding site	428	1	ATP By similarity
	Binding site	442	1	ATP By similarity
	Binding site	527	1	ATP By similarity
Amino acid modifications
	Modified residue	589	1	O-(pantetheine 4'-phosphoryl)serine By similarity
	Modified residue	649	1	Phosphoserine Ref.7
Natural variations
	Alternative sequence	1 – 100	100	Missing in isoform 2.		VSP_030707
	Alternative sequence	831 – 857	27	CYNGL…EDAVK → LAVLYQWTNLFIPVYLTIRA KNIFWFP in isoform 4.		VSP_030710
	Alternative sequence	831 – 841	11	CYNGLVYVLKS → KFLNLRFVELN in isoform 3.		VSP_030711
	Alternative sequence	842 – 1098	257	Missing in isoform 3.		VSP_030712
	Alternative sequence	858 – 1098	241	Missing in isoform 4.		VSP_030713
	Natural variant	61	1	I → V. Ref.6 Corresponds to variant rs34543011 [ dbSNP | Ensembl ].		VAR_061008
	Natural variant	93	1	P → R. Ref.6 Corresponds to variant rs34228795 [ dbSNP | Ensembl ].		VAR_061009
	Natural variant	368	1	K → R. Corresponds to variant rs3796543 [ dbSNP | Ensembl ].		VAR_038309
	Natural variant	747	1	A → V. Ref.2 Ref.5 Corresponds to variant rs3796544 [ dbSNP | Ensembl ].		VAR_038310
	Natural variant	774	1	V → I. Corresponds to variant rs3796545 [ dbSNP | Ensembl ].		VAR_038311
	Natural variant	865	1	T → A. Corresponds to variant rs12498340 [ dbSNP | Ensembl ].		VAR_038312
	Natural variant	1030	1	Y → D. Ref.1 Corresponds to variant rs8340 [ dbSNP | Ensembl ].		VAR_038313
Experimental info
	Sequence conflict	167	1	I → R in AAI41825. Ref.5
	Sequence conflict	167	1	I → R in AAI42710. Ref.5
	Sequence conflict	309	1	T → A in CAH56130. Ref.3
	Sequence conflict	428	1	D → G in AAQ83120. Ref.1
	Sequence conflict	428	1	D → G in CAH56482. Ref.3
	Sequence conflict	470	1	E → V in CAH56482. Ref.3
	Sequence conflict	489	1	K → Q in CAH56482. Ref.3
	Sequence conflict	498	1	F → L in CAH56482. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 24, 2009. Version 3. Checksum: 067ACB7C020AD4F1	FASTA	1,098	122,597
	10 20 30 40 50 60 MTLQELVHKA ASCYMDRVAV CFDECNNQLP VYYTYKTVVN AASELSNFLL LHCDFQGIRE 70 80 90 100 110 120 IGLYCQPGID LPSWILGILQ VPAAYVPIEP DSPPSLSTHF MKKCNLKYIL VEKKQINKFK 130 140 150 160 170 180 SFHETLLNYD TFTVEHNDLV LFRLHWKNTE VNLMLNDGKE KYEKEKIKSI SSEHVNEEKA 190 200 210 220 230 240 EEHMDLRLKH CLAYVLHTSG TTGIPKIVRV PHKCIVPNIQ HFRVLFDITQ EDVLFLASPL 250 260 270 280 290 300 TFDPSVVEIF LALSSGASLL IVPTSVKLLP SKLASVLFSH HRVTVLQATP TLLRRFGSQL 310 320 330 340 350 360 IKSTVLSATT SLRVLALGGE AFPSLTVLRS WRGEGNKTQI FNVYGITEVS SWATIYRIPE 370 380 390 400 410 420 KTLNSTLKCE LPVQLGFPLL GTVVEVRDTN GFTIQEGSGQ VFLGGRNRVC FLDDEVTVPL 430 440 450 460 470 480 GTMRATGDFV TVKDGEIFFL GRKDSQIKRH GKRLNIELVQ QVAEELQQVE SCAVTWYNQE 490 500 510 520 530 540 KLILFMVSKD ASVKEYIFKE LQKYLPSHAV PDELVLIDSL PFTSHGKIDV SELNKIYLNY 550 560 570 580 590 600 INLKSENKLS GKEDLWEKLQ YLWKSTLNLP EDLLRVPDES LFLNSGGDSL KSIRLLSEIE 610 620 630 640 650 660 KLVGTSVPGL LEIILSSSIL EIYNHILQTV VPDEDVTFRK SCATKRKLSD INQEEASGTS 670 680 690 700 710 720 LHQKAIMTFT CHNEINAFVV LSRGSQILSL NSTRFLTKLG HCSSACPSDS VSQTNIQNLK 730 740 750 760 770 780 GLNSPVLIGK SKDPSCVAKV SEEGKPAIGT QKMELHVRWR SDTGKCVDAS PLVVIPTFDK 790 800 810 820 830 840 SSTTVYIGSH SHRMKAVDFY SGKVKWEQIL GDRIESSACV SKCGNFIVVG CYNGLVYVLK 850 860 870 880 890 900 SNSGEKYWMF TTEDAVKSSA TMDPTTGLIY IGSHDQHAYA LDIYRKKCVW KSKCGGTVFS 910 920 930 940 950 960 SPCLNLIPHH LYFATLGGLL LAVNPATGNV IWKHSCGKPL FSSPQCCSQY ICIGCVDGNL 970 980 990 1000 1010 1020 LCFTHFGEQV WQFSTSGPIF SSPCTSPSEQ KIFFGSHDCF IYCCNMKGHL QWKFETTSRV 1030 1040 1050 1060 1070 1080 YATPFAFHNY NGSNEMLLAA ASTDGKVWIL ESQSGQLQSV YELPGEVFSS PVVLESMLII 1090 GCRDNYVYCL DLLGGNQK
	Isoform 2 [UniParc]. Checksum: 55CA500C21B0BA59	FASTA	998	111,420
	10 20 30 40 50 60 MKKCNLKYIL VEKKQINKFK SFHETLLNYD TFTVEHNDLV LFRLHWKNTE VNLMLNDGKE 70 80 90 100 110 120 KYEKEKIKSI SSEHVNEEKA EEHMDLRLKH CLAYVLHTSG TTGIPKIVRV PHKCIVPNIQ 130 140 150 160 170 180 HFRVLFDITQ EDVLFLASPL TFDPSVVEIF LALSSGASLL IVPTSVKLLP SKLASVLFSH 190 200 210 220 230 240 HRVTVLQATP TLLRRFGSQL IKSTVLSATT SLRVLALGGE AFPSLTVLRS WRGEGNKTQI 250 260 270 280 290 300 FNVYGITEVS SWATIYRIPE KTLNSTLKCE LPVQLGFPLL GTVVEVRDTN GFTIQEGSGQ 310 320 330 340 350 360 VFLGGRNRVC FLDDEVTVPL GTMRATGDFV TVKDGEIFFL GRKDSQIKRH GKRLNIELVQ 370 380 390 400 410 420 QVAEELQQVE SCAVTWYNQE KLILFMVSKD ASVKEYIFKE LQKYLPSHAV PDELVLIDSL 430 440 450 460 470 480 PFTSHGKIDV SELNKIYLNY INLKSENKLS GKEDLWEKLQ YLWKSTLNLP EDLLRVPDES 490 500 510 520 530 540 LFLNSGGDSL KSIRLLSEIE KLVGTSVPGL LEIILSSSIL EIYNHILQTV VPDEDVTFRK 550 560 570 580 590 600 SCATKRKLSD INQEEASGTS LHQKAIMTFT CHNEINAFVV LSRGSQILSL NSTRFLTKLG 610 620 630 640 650 660 HCSSACPSDS VSQTNIQNLK GLNSPVLIGK SKDPSCVAKV SEEGKPAIGT QKMELHVRWR 670 680 690 700 710 720 SDTGKCVDAS PLVVIPTFDK SSTTVYIGSH SHRMKAVDFY SGKVKWEQIL GDRIESSACV 730 740 750 760 770 780 SKCGNFIVVG CYNGLVYVLK SNSGEKYWMF TTEDAVKSSA TMDPTTGLIY IGSHDQHAYA 790 800 810 820 830 840 LDIYRKKCVW KSKCGGTVFS SPCLNLIPHH LYFATLGGLL LAVNPATGNV IWKHSCGKPL 850 860 870 880 890 900 FSSPQCCSQY ICIGCVDGNL LCFTHFGEQV WQFSTSGPIF SSPCTSPSEQ KIFFGSHDCF 910 920 930 940 950 960 IYCCNMKGHL QWKFETTSRV YATPFAFHNY NGSNEMLLAA ASTDGKVWIL ESQSGQLQSV 970 980 990 YELPGEVFSS PVVLESMLII GCRDNYVYCL DLLGGNQK
	Isoform 3 [UniParc]. Checksum: DDAF31A91E9453B3	FASTA	841	94,282
	10 20 30 40 50 60 MTLQELVHKA ASCYMDRVAV CFDECNNQLP VYYTYKTVVN AASELSNFLL LHCDFQGIRE 70 80 90 100 110 120 IGLYCQPGID LPSWILGILQ VPAAYVPIEP DSPPSLSTHF MKKCNLKYIL VEKKQINKFK 130 140 150 160 170 180 SFHETLLNYD TFTVEHNDLV LFRLHWKNTE VNLMLNDGKE KYEKEKIKSI SSEHVNEEKA 190 200 210 220 230 240 EEHMDLRLKH CLAYVLHTSG TTGIPKIVRV PHKCIVPNIQ HFRVLFDITQ EDVLFLASPL 250 260 270 280 290 300 TFDPSVVEIF LALSSGASLL IVPTSVKLLP SKLASVLFSH HRVTVLQATP TLLRRFGSQL 310 320 330 340 350 360 IKSTVLSATT SLRVLALGGE AFPSLTVLRS WRGEGNKTQI FNVYGITEVS SWATIYRIPE 370 380 390 400 410 420 KTLNSTLKCE LPVQLGFPLL GTVVEVRDTN GFTIQEGSGQ VFLGGRNRVC FLDDEVTVPL 430 440 450 460 470 480 GTMRATGDFV TVKDGEIFFL GRKDSQIKRH GKRLNIELVQ QVAEELQQVE SCAVTWYNQE 490 500 510 520 530 540 KLILFMVSKD ASVKEYIFKE LQKYLPSHAV PDELVLIDSL PFTSHGKIDV SELNKIYLNY 550 560 570 580 590 600 INLKSENKLS GKEDLWEKLQ YLWKSTLNLP EDLLRVPDES LFLNSGGDSL KSIRLLSEIE 610 620 630 640 650 660 KLVGTSVPGL LEIILSSSIL EIYNHILQTV VPDEDVTFRK SCATKRKLSD INQEEASGTS 670 680 690 700 710 720 LHQKAIMTFT CHNEINAFVV LSRGSQILSL NSTRFLTKLG HCSSACPSDS VSQTNIQNLK 730 740 750 760 770 780 GLNSPVLIGK SKDPSCVAKV SEEGKPAIGT QKMELHVRWR SDTGKCVDAS PLVVIPTFDK 790 800 810 820 830 840 SSTTVYIGSH SHRMKAVDFY SGKVKWEQIL GDRIESSACV SKCGNFIVVG KFLNLRFVEL N
	Isoform 4 [UniParc]. Checksum: FCF911A56BB00CA7	FASTA	857	96,217
	10 20 30 40 50 60 MTLQELVHKA ASCYMDRVAV CFDECNNQLP VYYTYKTVVN AASELSNFLL LHCDFQGIRE 70 80 90 100 110 120 IGLYCQPGID LPSWILGILQ VPAAYVPIEP DSPPSLSTHF MKKCNLKYIL VEKKQINKFK 130 140 150 160 170 180 SFHETLLNYD TFTVEHNDLV LFRLHWKNTE VNLMLNDGKE KYEKEKIKSI SSEHVNEEKA 190 200 210 220 230 240 EEHMDLRLKH CLAYVLHTSG TTGIPKIVRV PHKCIVPNIQ HFRVLFDITQ EDVLFLASPL 250 260 270 280 290 300 TFDPSVVEIF LALSSGASLL IVPTSVKLLP SKLASVLFSH HRVTVLQATP TLLRRFGSQL 310 320 330 340 350 360 IKSTVLSATT SLRVLALGGE AFPSLTVLRS WRGEGNKTQI FNVYGITEVS SWATIYRIPE 370 380 390 400 410 420 KTLNSTLKCE LPVQLGFPLL GTVVEVRDTN GFTIQEGSGQ VFLGGRNRVC FLDDEVTVPL 430 440 450 460 470 480 GTMRATGDFV TVKDGEIFFL GRKDSQIKRH GKRLNIELVQ QVAEELQQVE SCAVTWYNQE 490 500 510 520 530 540 KLILFMVSKD ASVKEYIFKE LQKYLPSHAV PDELVLIDSL PFTSHGKIDV SELNKIYLNY 550 560 570 580 590 600 INLKSENKLS GKEDLWEKLQ YLWKSTLNLP EDLLRVPDES LFLNSGGDSL KSIRLLSEIE 610 620 630 640 650 660 KLVGTSVPGL LEIILSSSIL EIYNHILQTV VPDEDVTFRK SCATKRKLSD INQEEASGTS 670 680 690 700 710 720 LHQKAIMTFT CHNEINAFVV LSRGSQILSL NSTRFLTKLG HCSSACPSDS VSQTNIQNLK 730 740 750 760 770 780 GLNSPVLIGK SKDPSCVAKV SEEGKPAIGT QKMELHVRWR SDTGKCVDAS PLVVIPTFDK 790 800 810 820 830 840 SSTTVYIGSH SHRMKAVDFY SGKVKWEQIL GDRIESSACV SKCGNFIVVG LAVLYQWTNL 850 FIPVYLTIRA KNIFWFP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a novel human homolog of mouse U26, a putative PQQ-dependent AAS dehydrogenase." Wang L., Jil C., Xu Y., Xu J., Dai J., Wu Q., Wu M., Zou X., Sun L., Gu S., Xie Y., Mao Y. Mol. Biol. Rep. 32:47-53(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT ASP-1030. Tissue: Fetal brain.
[2]	"Identification and preliminary characterization of a human protein with similarity to microbial peptide synthetases." Paliga K., Bauer K. Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-747.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 96-1098. Tissue: Liver and Small intestine.
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), VARIANT VAL-747.
[6]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-164, VARIANTS VAL-61 AND ARG-93. Tissue: Umbilical cord blood.
[7]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-649, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY314787 mRNA. Translation: AAQ83120.1. AF516672 mRNA. Translation: AAP76519.1. AY422212 mRNA. Translation: AAR31184.1. BX640635 Transcribed RNA. Translation: CAH56482.1. Different initiation. BX648853 mRNA. Translation: CAH56130.1. AC068620 Genomic DNA. No translation available. BC071815 mRNA. Translation: AAH71815.1. BC141824 mRNA. Translation: AAI41825.1. BC142709 mRNA. Translation: AAI42710.1. AF161436 mRNA. Translation: AAF28996.1.
IPI	IPI00419992. IPI00879043. IPI00879228. IPI00880184.
RefSeq	NP_861522.2. NM_181806.2.
UniGene	Hs.104347.
3D structure databases
ProteinModelPortal	Q4L235.
SMR	Q4L235. Positions 130-539, 758-1095.
ModBase	Search...
PTM databases
PhosphoSite	Q4L235.
Polymorphism databases
DMDM	269849683.
Proteomic databases
PaxDb	Q4L235.
PRIDE	Q4L235.
Protocols and materials databases
DNASU	132949.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000205214; ENSP00000205214; ENSG00000157426. ENST00000451613; ENSP00000409656; ENSG00000157426. ENST00000502617; ENSP00000421171; ENSG00000157426. ENST00000513376; ENSP00000423760; ENSG00000157426.
GeneID	132949.
KEGG	hsa:132949.
UCSC	uc003hbn.3. human. uc003hbp.3. human. uc010ihc.3. human.
Organism-specific databases
CTD	132949.
GeneCards	GC04M057204.
H-InvDB	HIX0024559.
HGNC	HGNC:23993. AASDH.
HPA	HPA036473.
MIM	614365. gene.
neXtProt	NX_Q4L235.
PharmGKB	PA162375178.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1520.
HOVERGEN	HBG057704.
InParanoid	Q4L235.
KO	K00142.
OMA	TMRATGD.
OrthoDB	EOG415GCV.
PhylomeDB	Q4L235.
Enzyme and pathway databases
BRENDA	1.2.1.31. 2681.
Gene expression databases
ArrayExpress	Q4L235.
Bgee	Q4L235.
CleanEx	HS_AASDH.
Genevestigator	Q4L235.
Family and domain databases
Gene3D	1.10.1200.10. 1 hit. 2.140.10.10. 1 hit.
InterPro	IPR026897. ACSF4. IPR009081. Acyl_carrier_prot-like. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. IPR018391. PQQ_beta_propeller_repeat. IPR027295. Quinonprotein_ADH-like_fam. IPR011047. Quinonprotein_ADH-like_supfam. [Graphical view]
PANTHER	PTHR24095:SF18. PTHR24095:SF18. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF00550. PP-binding. 1 hit. [Graphical view]
SMART	SM00564. PQQ. 6 hits. [Graphical view]
SUPFAM	SSF50998. Quin_alc_DH_like. 1 hit.
PROSITE	PS50075. ACP_DOMAIN. 1 hit. PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	AASDH. human.
GenomeRNAi	132949.
NextBio	83164.
SOURCE	Search...

Entry information

Entry name

ACSF4_HUMAN

Accession

Primary (citable) accession number: Q4L235
Secondary accession number(s): A5D8V3 , A5PL22, Q63HK2, Q63HR7, Q6IPP8, Q6TFZ6, Q7Z5Y3, Q96BW4, Q9P064

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 24, 2009
Last modified:	May 29, 2013
This is version 71 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.