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Protein

Sodium/hydrogen exchanger 8

Gene

Slc9a8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/hydrogen exchanger 8
Alternative name(s):
Na(+)/H(+) exchanger 8
Short name:
NHE-8
Solute carrier family 9 member 8
Gene namesi
Name:Slc9a8
Synonyms:Nhe8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1308193. Slc9a8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei54 – 7421HelicalSequence analysisAdd
BLAST
Transmembranei78 – 9821HelicalSequence analysisAdd
BLAST
Transmembranei117 – 13721HelicalSequence analysisAdd
BLAST
Transmembranei150 – 17021HelicalSequence analysisAdd
BLAST
Transmembranei185 – 20521HelicalSequence analysisAdd
BLAST
Transmembranei255 – 27521HelicalSequence analysisAdd
BLAST
Transmembranei305 – 32521HelicalSequence analysisAdd
BLAST
Transmembranei348 – 36821HelicalSequence analysisAdd
BLAST
Transmembranei373 – 39321HelicalSequence analysisAdd
BLAST
Transmembranei411 – 43121HelicalSequence analysisAdd
BLAST
Transmembranei445 – 46521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 575575Sodium/hydrogen exchanger 8PRO_0000379803Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei504 – 5041PhosphothreonineBy similarity
Modified residuei565 – 5651PhosphoserineBy similarity
Modified residuei567 – 5671PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4L208.
PRIDEiQ4L208.

PTM databases

PhosphoSiteiQ4L208.

Expressioni

Tissue specificityi

Intestine. Shows an apical localization in intestinal epithelial cells.1 Publication

Developmental stagei

Expression is higher in 2 and 3 week old rats and lower in adults.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012175.

Structurei

3D structure databases

ProteinModelPortaliQ4L208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1965. Eukaryota.
COG0025. LUCA.
HOGENOMiHOG000172307.
InParanoidiQ4L208.
KOiK14724.
PhylomeDBiQ4L208.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR018409. Na/H_exchanger_8.
IPR004709. NaH_exchanger.
[Graphical view]
PANTHERiPTHR10110. PTHR10110. 1 hit.
PTHR10110:SF122. PTHR10110:SF122. 1 hit.
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
PRINTSiPR01084. NAHEXCHNGR.
TIGRFAMsiTIGR00840. b_cpa1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4L208-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEFSNTTH ESFNFTLHTT LGVTTKLVLP TPAEPILPVQ TGEQAQQEEQ
60 70 80 90 100
SSGMTIFFSL LVLAICIILV HLLIRYRLHF LPESVAVVSL GILMGAVIKV
110 120 130 140 150
IEFKKLANWK EEEMFRPNMF FLLLLPPIIF ESGYSLHKGN FFQNIGSITL
160 170 180 190 200
FAVFGTAISA FVVGGGIYFL GQADVISKLN MTDSFAFGSL ISAVDPVATI
210 220 230 240 250
AIFNALHVDP VLNMLVFGES ILNDAVSIVL TNTAEGLTRK HMSDVSGWQT
260 270 280 290 300
FSQALGYFLK MFFGSAALGT LTGLISALVL KHIDLRKTPS LEFGMMIIFA
310 320 330 340 350
YLPYGLAEGI SLSGIMAILF SGIVMSHYTH HNLSPVTQIL MQQTLRTVAF
360 370 380 390 400
LCETCVFAFL GLSIFSFPHK FEISFVIWCI VLVLFGRAVN IFPLSYLLNF
410 420 430 440 450
FRDHKITPKM MFIMWFSGLR GAIPYALSLH LGLEPMEKRQ LIGTTTIIIV
460 470 480 490 500
LFTILLLGGS TMPLIRLVDI EDARARRRSK KDVNLSKTEK MGNAIESEHL
510 520 530 540 550
SELTEEEYEA HYIRQQDLKG FMWLDAKYLN PFFTRRLTQE DLHHGRIQMK
560 570
SLTNKWYEEV RQGPSGSEDD EQELF
Length:575
Mass (Da):64,609
Last modified:August 2, 2005 - v1
Checksum:i57E85DEFB7122C2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY496958 mRNA. Translation: AAS75864.1.
RefSeqiNP_001020452.1. NM_001025281.1.
UniGeneiRn.153853.

Genome annotation databases

GeneIDi311651.
KEGGirno:311651.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY496958 mRNA. Translation: AAS75864.1.
RefSeqiNP_001020452.1. NM_001025281.1.
UniGeneiRn.153853.

3D structure databases

ProteinModelPortaliQ4L208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012175.

PTM databases

PhosphoSiteiQ4L208.

Proteomic databases

PaxDbiQ4L208.
PRIDEiQ4L208.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi311651.
KEGGirno:311651.

Organism-specific databases

CTDi23315.
RGDi1308193. Slc9a8.

Phylogenomic databases

eggNOGiKOG1965. Eukaryota.
COG0025. LUCA.
HOGENOMiHOG000172307.
InParanoidiQ4L208.
KOiK14724.
PhylomeDBiQ4L208.

Miscellaneous databases

NextBioi663992.
PROiQ4L208.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR018409. Na/H_exchanger_8.
IPR004709. NaH_exchanger.
[Graphical view]
PANTHERiPTHR10110. PTHR10110. 1 hit.
PTHR10110:SF122. PTHR10110:SF122. 1 hit.
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
PRINTSiPR01084. NAHEXCHNGR.
TIGRFAMsiTIGR00840. b_cpa1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Subcloning, localization, and expression of the rat intestinal sodium-hydrogen exchanger isoform 8."
    Xu H., Chen R., Ghishan F.K.
    Am. J. Physiol. 289:G36-G41(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiSL9A8_RAT
AccessioniPrimary (citable) accession number: Q4L208
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: August 2, 2005
Last modified: November 11, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.