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Q4L0E8

- RGS18_RAT

UniProt

Q4L0E8 - RGS18_RAT

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Protein

Regulator of G-protein signaling 18

Gene

Rgs18

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha (By similarity).By similarity

GO - Molecular functioni

  1. GTPase activator activity Source: RefGenome

GO - Biological processi

  1. positive regulation of GTPase activity Source: GOC
  2. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 18
Short name:
RGS18
Gene namesi
Name:Rgs18
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1306522. Rgs18.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235Regulator of G-protein signaling 18PRO_0000342605Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ4L0E8.

Expressioni

Gene expression databases

GenevestigatoriQ4L0E8.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005324.

Structurei

3D structure databases

ProteinModelPortaliQ4L0E8.
SMRiQ4L0E8. Positions 75-206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini86 – 202117RGSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG278594.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiQ4L0E8.
KOiK16449.
PhylomeDBiQ4L0E8.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4L0E8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDMSLVFFSH LNMCESKEKT FFKLMHGSGK EETNIEAKIR AKEKRNRLSL
60 70 80 90 100
LLQRPDFHGE THTSRSALLA KETRVSSEEA LKWAESFDKL LSHRDGVDAF
110 120 130 140 150
TRFLKTEFSE ENIEFWVACE DFKKCTEPQQ LILKAKSIYE KFIKNDAPKE
160 170 180 190 200
VNLDFHTKEV ITKSIAQPTL HSFDAAQSRV CQLMEHDSYK RFLKSEIYLH
210 220 230
LIEGRPQRPT NLRRRSRSFT YNEFQDVKSD VAIWL
Length:235
Mass (Da):27,645
Last modified:August 2, 2005 - v1
Checksum:i12BB334292AB6D67
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY651776 mRNA. Translation: AAV85503.1.
RefSeqiNP_001040549.1. NM_001047084.1.
UniGeneiRn.202353.

Genome annotation databases

GeneIDi289076.
KEGGirno:289076.
UCSCiRGD:1306522. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY651776 mRNA. Translation: AAV85503.1 .
RefSeqi NP_001040549.1. NM_001047084.1.
UniGenei Rn.202353.

3D structure databases

ProteinModelPortali Q4L0E8.
SMRi Q4L0E8. Positions 75-206.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000005324.

Proteomic databases

PRIDEi Q4L0E8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 289076.
KEGGi rno:289076.
UCSCi RGD:1306522. rat.

Organism-specific databases

CTDi 64407.
RGDi 1306522. Rgs18.

Phylogenomic databases

eggNOGi NOG278594.
HOGENOMi HOG000233512.
HOVERGENi HBG013233.
InParanoidi Q4L0E8.
KOi K16449.
PhylomeDBi Q4L0E8.

Miscellaneous databases

NextBioi 629173.
PROi Q4L0E8.

Gene expression databases

Genevestigatori Q4L0E8.

Family and domain databases

Gene3Di 1.10.196.10. 2 hits.
InterProi IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view ]
Pfami PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
PROSITEi PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression of regulator of G protein signalling proteins in natural killer cells, and their modulation by Ly49A and Ly49D."
    Kveberg L., Ryan J.C., Rolstad B., Inngjerdingen M.
    Immunology 115:358-365(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Fischer 344.

Entry informationi

Entry nameiRGS18_RAT
AccessioniPrimary (citable) accession number: Q4L0E8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: August 2, 2005
Last modified: October 1, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3