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Q4L0E8 (RGS18_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Regulator of G-protein signaling 18

Short name=RGS18
Gene names
Name:Rgs18
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Contains 1 RGS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 235235Regulator of G-protein signaling 18
PRO_0000342605

Regions

Domain86 – 202117RGS

Amino acid modifications

Modified residue491Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4L0E8 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: 12BB334292AB6D67

FASTA23527,645
        10         20         30         40         50         60 
MDMSLVFFSH LNMCESKEKT FFKLMHGSGK EETNIEAKIR AKEKRNRLSL LLQRPDFHGE 

        70         80         90        100        110        120 
THTSRSALLA KETRVSSEEA LKWAESFDKL LSHRDGVDAF TRFLKTEFSE ENIEFWVACE 

       130        140        150        160        170        180 
DFKKCTEPQQ LILKAKSIYE KFIKNDAPKE VNLDFHTKEV ITKSIAQPTL HSFDAAQSRV 

       190        200        210        220        230 
CQLMEHDSYK RFLKSEIYLH LIEGRPQRPT NLRRRSRSFT YNEFQDVKSD VAIWL 

« Hide

References

[1]"Expression of regulator of G protein signalling proteins in natural killer cells, and their modulation by Ly49A and Ly49D."
Kveberg L., Ryan J.C., Rolstad B., Inngjerdingen M.
Immunology 115:358-365(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Fischer 344.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY651776 mRNA. Translation: AAV85503.1.
RefSeqNP_001040549.1. NM_001047084.1.
UniGeneRn.202353.

3D structure databases

ProteinModelPortalQ4L0E8.
SMRQ4L0E8. Positions 75-206.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000005324.

Proteomic databases

PRIDEQ4L0E8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID289076.
KEGGrno:289076.
UCSCRGD:1306522. rat.

Organism-specific databases

CTD64407.
RGD1306522. Rgs18.

Phylogenomic databases

eggNOGNOG278594.
HOGENOMHOG000233512.
HOVERGENHBG013233.
InParanoidQ4L0E8.
KOK16449.
PhylomeDBQ4L0E8.

Gene expression databases

GenevestigatorQ4L0E8.

Family and domain databases

Gene3D1.10.196.10. 2 hits.
InterProIPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamPF00615. RGS. 1 hit.
[Graphical view]
PRINTSPR01301. RGSPROTEIN.
SMARTSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMSSF48097. SSF48097. 1 hit.
PROSITEPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio629173.
PROQ4L0E8.

Entry information

Entry nameRGS18_RAT
AccessionPrimary (citable) accession number: Q4L0E8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: August 2, 2005
Last modified: April 16, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families