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Protein

Regulator of G-protein signaling 18

Gene

Rgs18

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 18
Short name:
RGS18
Gene namesi
Name:Rgs18
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1306522 Rgs18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003426051 – 235Regulator of G-protein signaling 18Add BLAST235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49PhosphoserineBy similarity1
Modified residuei216PhosphoserineBy similarity1
Modified residuei218PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4L0E8
PRIDEiQ4L0E8

PTM databases

iPTMnetiQ4L0E8
PhosphoSitePlusiQ4L0E8

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005324

Structurei

3D structure databases

ProteinModelPortaliQ4L0E8
SMRiQ4L0E8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 202RGSPROSITE-ProRule annotationAdd BLAST117

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
HOGENOMiHOG000233512
HOVERGENiHBG013233
InParanoidiQ4L0E8
KOiK16449
PhylomeDBiQ4L0E8

Family and domain databases

Gene3Di1.10.196.10, 2 hits
InterProiView protein in InterPro
IPR016137 RGS
IPR034950 RGS18
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PANTHERiPTHR10845:SF155 PTHR10845:SF155, 1 hit
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit

Sequencei

Sequence statusi: Complete.

Q4L0E8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMSLVFFSH LNMCESKEKT FFKLMHGSGK EETNIEAKIR AKEKRNRLSL
60 70 80 90 100
LLQRPDFHGE THTSRSALLA KETRVSSEEA LKWAESFDKL LSHRDGVDAF
110 120 130 140 150
TRFLKTEFSE ENIEFWVACE DFKKCTEPQQ LILKAKSIYE KFIKNDAPKE
160 170 180 190 200
VNLDFHTKEV ITKSIAQPTL HSFDAAQSRV CQLMEHDSYK RFLKSEIYLH
210 220 230
LIEGRPQRPT NLRRRSRSFT YNEFQDVKSD VAIWL
Length:235
Mass (Da):27,645
Last modified:August 2, 2005 - v1
Checksum:i12BB334292AB6D67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY651776 mRNA Translation: AAV85503.1
RefSeqiNP_001040549.1, NM_001047084.1
UniGeneiRn.105775
Rn.202353

Genome annotation databases

GeneIDi289076
KEGGirno:289076
UCSCiRGD:1306522 rat

Similar proteinsi

Entry informationi

Entry nameiRGS18_RAT
AccessioniPrimary (citable) accession number: Q4L0E8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: August 2, 2005
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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