Q4L0E8 (RGS18_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Regulator of G-protein signaling 18
Short name=RGS18

Gene names

Name:

Rgs18

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	235 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Contains 1 RGS domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Signal transduction inhibitor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	termination of G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from Biological aspect of Ancestor. Source: RefGenome plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	GTPase activator activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 235	235	Regulator of G-protein signaling 18		PRO_0000342605
Regions
	Domain	86 – 202	117	RGS
Amino acid modifications
	Modified residue	49	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4L0E8 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 12BB334292AB6D67	FASTA	235	27,645
	10 20 30 40 50 60 MDMSLVFFSH LNMCESKEKT FFKLMHGSGK EETNIEAKIR AKEKRNRLSL LLQRPDFHGE 70 80 90 100 110 120 THTSRSALLA KETRVSSEEA LKWAESFDKL LSHRDGVDAF TRFLKTEFSE ENIEFWVACE 130 140 150 160 170 180 DFKKCTEPQQ LILKAKSIYE KFIKNDAPKE VNLDFHTKEV ITKSIAQPTL HSFDAAQSRV 190 200 210 220 230 CQLMEHDSYK RFLKSEIYLH LIEGRPQRPT NLRRRSRSFT YNEFQDVKSD VAIWL

References

[1]	"Expression of regulator of G protein signalling proteins in natural killer cells, and their modulation by Ly49A and Ly49D." Kveberg L., Ryan J.C., Rolstad B., Inngjerdingen M. Immunology 115:358-365(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Fischer 344.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY651776 mRNA. Translation: AAV85503.1.
IPI	IPI00203674.
RefSeq	NP_001040549.1. NM_001047084.1.
UniGene	Rn.202353.
3D structure databases
HSSP	HSSP built from PDB template 1AGR based on UniProtKB P49799.
ProteinModelPortal	Q4L0E8.
SMR	Q4L0E8. Positions 75-206.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000005324.
Proteomic databases
PRIDE	Q4L0E8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	289076.
KEGG	rno:289076.
UCSC	RGD:1306522. rat.
Organism-specific databases
CTD	64407.
RGD	1306522. Rgs18.
Phylogenomic databases
eggNOG	NOG278594.
HOGENOM	HOG000233512.
HOVERGEN	HBG013233.
InParanoid	Q4L0E8.
KO	K16449.
OrthoDB	EOG42BX9H.
Gene expression databases
Genevestigator	Q4L0E8.
Family and domain databases
Gene3D	1.10.196.10. 2 hits.
InterPro	IPR000342. Regulat_G_prot_signal. IPR024066. Regulat_G_prot_signal_dom1. IPR016137. Regulat_G_prot_signal_superfam. [Graphical view]
Pfam	PF00615. RGS. 1 hit. [Graphical view]
PRINTS	PR01301. RGSPROTEIN.
SMART	SM00315. RGS. 1 hit. [Graphical view]
SUPFAM	SSF48097. Regulat_G_prot_signal_superfam. 1 hit.
PROSITE	PS50132. RGS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	629173.

Entry information

Entry name

RGS18_RAT

Accession

Primary (citable) accession number: Q4L0E8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	August 2, 2005
Last modified:	April 3, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program