Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q4L0E8

- RGS18_RAT

UniProt

Q4L0E8 - RGS18_RAT

Protein

Regulator of G-protein signaling 18

Gene

Rgs18

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (02 Aug 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha By similarity.By similarity

    GO - Molecular functioni

    1. GTPase activator activity Source: RefGenome

    GO - Biological processi

    1. positive regulation of GTPase activity Source: GOC
    2. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 18
    Short name:
    RGS18
    Gene namesi
    Name:Rgs18
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1306522. Rgs18.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 235235Regulator of G-protein signaling 18PRO_0000342605Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei49 – 491PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ4L0E8.

    Expressioni

    Gene expression databases

    GenevestigatoriQ4L0E8.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000005324.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4L0E8.
    SMRiQ4L0E8. Positions 75-206.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini86 – 202117RGSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG278594.
    HOGENOMiHOG000233512.
    HOVERGENiHBG013233.
    InParanoidiQ4L0E8.
    KOiK16449.
    PhylomeDBiQ4L0E8.

    Family and domain databases

    Gene3Di1.10.196.10. 2 hits.
    InterProiIPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view]
    PfamiPF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    PROSITEiPS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4L0E8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDMSLVFFSH LNMCESKEKT FFKLMHGSGK EETNIEAKIR AKEKRNRLSL    50
    LLQRPDFHGE THTSRSALLA KETRVSSEEA LKWAESFDKL LSHRDGVDAF 100
    TRFLKTEFSE ENIEFWVACE DFKKCTEPQQ LILKAKSIYE KFIKNDAPKE 150
    VNLDFHTKEV ITKSIAQPTL HSFDAAQSRV CQLMEHDSYK RFLKSEIYLH 200
    LIEGRPQRPT NLRRRSRSFT YNEFQDVKSD VAIWL 235
    Length:235
    Mass (Da):27,645
    Last modified:August 2, 2005 - v1
    Checksum:i12BB334292AB6D67
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY651776 mRNA. Translation: AAV85503.1.
    RefSeqiNP_001040549.1. NM_001047084.1.
    UniGeneiRn.202353.

    Genome annotation databases

    GeneIDi289076.
    KEGGirno:289076.
    UCSCiRGD:1306522. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY651776 mRNA. Translation: AAV85503.1 .
    RefSeqi NP_001040549.1. NM_001047084.1.
    UniGenei Rn.202353.

    3D structure databases

    ProteinModelPortali Q4L0E8.
    SMRi Q4L0E8. Positions 75-206.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000005324.

    Proteomic databases

    PRIDEi Q4L0E8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 289076.
    KEGGi rno:289076.
    UCSCi RGD:1306522. rat.

    Organism-specific databases

    CTDi 64407.
    RGDi 1306522. Rgs18.

    Phylogenomic databases

    eggNOGi NOG278594.
    HOGENOMi HOG000233512.
    HOVERGENi HBG013233.
    InParanoidi Q4L0E8.
    KOi K16449.
    PhylomeDBi Q4L0E8.

    Miscellaneous databases

    NextBioi 629173.
    PROi Q4L0E8.

    Gene expression databases

    Genevestigatori Q4L0E8.

    Family and domain databases

    Gene3Di 1.10.196.10. 2 hits.
    InterProi IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view ]
    Pfami PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    PROSITEi PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of regulator of G protein signalling proteins in natural killer cells, and their modulation by Ly49A and Ly49D."
      Kveberg L., Ryan J.C., Rolstad B., Inngjerdingen M.
      Immunology 115:358-365(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Fischer 344.

    Entry informationi

    Entry nameiRGS18_RAT
    AccessioniPrimary (citable) accession number: Q4L0E8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: August 2, 2005
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3