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Protein

DNA repair protein REV1

Gene

REV1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents (By similarity). May play a role in homologous recombination and immunoglobulin gene conversion.By similarity1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei362 – 3621dCTPBy similarity
Metal bindingi427 – 4271MagnesiumPROSITE-ProRule annotation
Metal bindingi427 – 4271Magnesium 1PROSITE-ProRule annotation
Metal bindingi427 – 4271Magnesium 2PROSITE-ProRule annotation
Binding sitei533 – 5331dCTPBy similarity
Metal bindingi581 – 5811MagnesiumPROSITE-ProRule annotation
Metal bindingi581 – 5811Magnesium 1PROSITE-ProRule annotation
Binding sitei581 – 5811dCTPBy similarity
Metal bindingi582 – 5821Magnesium 1PROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi427 – 4315dCTP bindingBy similarity
Nucleotide bindingi521 – 5277dCTP bindingBy similarity

GO - Molecular functioni

GO - Biological processi

  • DNA repair Source: Reactome
  • double-strand break repair Source: UniProtKB
  • error-prone translesion synthesis Source: InterPro
  • gene conversion of immunoglobulin genes Source: UniProtKB
  • translesion synthesis Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA damage, DNA repair, DNA synthesis

Keywords - Ligandi

DNA-binding, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-GGA-353503. Translesion synthesis by Pol kappa.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein REV1 (EC:2.7.7.-)
Alternative name(s):
Rev1-like terminal deoxycytidyl transferase
Gene namesi
Name:REV1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12551255DNA repair protein REV1PRO_0000405249Add
BLAST

Proteomic databases

PaxDbiQ4KWZ7.

Interactioni

Subunit structurei

Monomer.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei781 – 7811Interaction with target DNABy similarity
Sitei794 – 7941Interaction with target DNABy similarity

Protein-protein interaction databases

BioGridi679901. 1 interaction.
STRINGi9031.ENSGALP00000027018.

Structurei

3D structure databases

ProteinModelPortaliQ4KWZ7.
SMRiQ4KWZ7. Positions 51-136.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 13488BRCTPROSITE-ProRule annotationAdd
BLAST
Domaini423 – 664242UmuCPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni357 – 36711Interaction with target DNABy similarityAdd
BLAST
Regioni664 – 6674Interaction with target DNABy similarity
Regioni720 – 7289Interaction with target DNABy similarity
Regioni1156 – 1255100Protein interaction domainBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1079 – 10857Nuclear localization signalBy similarity

Domaini

The C-terminal domain is necessary for protein interactions.By similarity

Sequence similaritiesi

Belongs to the DNA polymerase type-Y family.Curated
Contains 1 BRCT domain.PROSITE-ProRule annotation
Contains 1 umuC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2093. Eukaryota.
COG0389. LUCA.
HOGENOMiHOG000154094.
HOVERGENiHBG054140.
InParanoidiQ4KWZ7.
KOiK03515.
PhylomeDBiQ4KWZ7.

Family and domain databases

Gene3Di3.30.1490.100. 1 hit.
3.40.50.10190. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR017961. DNA_pol_Y-fam_little_finger.
IPR025527. DUF4414.
IPR012112. REV1.
IPR031991. Rev1_C.
IPR001126. UmuC.
[Graphical view]
PfamiPF16589. BRCT_2. 1 hit.
PF14377. DUF4414. 1 hit.
PF00817. IMS. 1 hit.
PF11799. IMS_C. 1 hit.
PF16727. REV1_C. 1 hit.
[Graphical view]
PIRSFiPIRSF036573. REV1. 1 hit.
SMARTiSM00292. BRCT. 1 hit.
[Graphical view]
SUPFAMiSSF100879. SSF100879. 1 hit.
SSF52113. SSF52113. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS50173. UMUC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4KWZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRGGWRKRA GEGDGWGGWG GYMSAKVKKL EDQFRSDSAI QHQRDGNSSS
60 70 80 90 100
IFSGVAIYVN GFTDPSADEL RRLMMLHGGQ YHVYYSRSKT THIIATNLPN
110 120 130 140 150
AKIKELKGEK VVRPEWIVES IKAGRLLSHI PYQLYTKQSS VQKGLSFNSI
160 170 180 190 200
CKPEDAMPGP SNIAKDLNRV NHIKQCEMES EITPNGISSW NEEEEEDSDG
210 220 230 240 250
LGFTKLDQIL PERKQNGIQS HKDSTAIFNG HTHNTCISAL KTQDCLVPSS
260 270 280 290 300
NSVASRFSPG PVQEEGKPEK GIVDFRDCTM QQLQQSNKNT DFSWNPHRTM
310 320 330 340 350
SNSSSSSSLH SNTKINGAHH STVQGPSSTK STSVPTPSKA ASLSVSKPSD
360 370 380 390 400
CSFISDFYSR SRLHHISTWK CELTEFVNSL QRKNSGVFPG REKLKKWKAG
410 420 430 440 450
RSALKTDTGN VSVASSAKPQ SCIMHVDMDC FFVSVAIRNR PDLKGKPVAV
460 470 480 490 500
TSNRGAGKAP LRPGANPQLE WQYYQNKLLN GKAEIRIPDK LDSLVWEHSD
510 520 530 540 550
SAHMNGVDCD LTVLSMAEIA SCSYEARQAG IKNGMFFGQA KKLCPNLQAV
560 570 580 590 600
SYDFNAYKEV AQTVYEILAS YTHNIEAVSC DEALVDITEI LTETRLTPDE
610 620 630 640 650
LANAIRDEIK AQTKCTASVG MGSNILLARM ATRKAKPDGQ YHLKPEEVDD
660 670 680 690 700
FIRGQLVTNL PGVGRSMESK LASLGIRTCG DLQCASMSKL QKEFGPKTGQ
710 720 730 740 750
MLYRFCRGLD DRPVRTEKER KSVSAEINYG IRFTQPKEAE AFLLSLSEEI
760 770 780 790 800
QRRLEAAGMK GKRLTLKIMV RKAGAPVEPA KYGGHGICDN IARTVTLDHA
810 820 830 840 850
TDSAKVIGKE TLNMFHTMKL NISDMRGVGI QVQQLVPISK TTSAQSAVQS
860 870 880 890 900
GRLPGGSHSV IDLLHVQKAK KCSEEEHKEV FVAAMDLEIS SDSRTCTVLP
910 920 930 940 950
SRGTHLTAGL NSNVSKTDSA VKLNGLHSPI SVKSRLNLSI EVPSASQLDK
960 970 980 990 1000
SVLEALPPDL REQVEQIYTI QQGETYGDSK REPINGCNTA LLSQPVGTVL
1010 1020 1030 1040 1050
LQVPELQEPN ANMGINVIAL PAFSQVDPEV FAALPAELQA ELKDAYDQRQ
1060 1070 1080 1090 1100
KQPEQQPANA FVSKNPCLQL KHATTKNKKK IRKKNPVSPV KKIQSPLKNK
1110 1120 1130 1140 1150
LLGSPAKNMP AASGSPQKLI DGFLKQEGAA AQLEAVPSTS DASDPSALQT
1160 1170 1180 1190 1200
EQCGSFRPQA PNLAGAVEFN DVKTLLKEWI TTISDPMEED ILQVVKYCTD
1210 1220 1230 1240 1250
LIEEKDLEKL DLVVKYMKRL MQSSVESVWN MAFDFILDNV QVVLQQTYGS

TLKVI
Length:1,255
Mass (Da):138,065
Last modified:August 2, 2005 - v1
Checksum:iA8B151298C80682C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY675169 mRNA. Translation: AAV80844.1.
RefSeqiNP_001025982.2. NM_001030811.2.
UniGeneiGga.24037.

Genome annotation databases

GeneIDi418703.
KEGGigga:418703.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY675169 mRNA. Translation: AAV80844.1.
RefSeqiNP_001025982.2. NM_001030811.2.
UniGeneiGga.24037.

3D structure databases

ProteinModelPortaliQ4KWZ7.
SMRiQ4KWZ7. Positions 51-136.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi679901. 1 interaction.
STRINGi9031.ENSGALP00000027018.

Proteomic databases

PaxDbiQ4KWZ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi418703.
KEGGigga:418703.

Organism-specific databases

CTDi51455.

Phylogenomic databases

eggNOGiKOG2093. Eukaryota.
COG0389. LUCA.
HOGENOMiHOG000154094.
HOVERGENiHBG054140.
InParanoidiQ4KWZ7.
KOiK03515.
PhylomeDBiQ4KWZ7.

Enzyme and pathway databases

ReactomeiR-GGA-353503. Translesion synthesis by Pol kappa.

Miscellaneous databases

NextBioi20821851.
PROiQ4KWZ7.

Family and domain databases

Gene3Di3.30.1490.100. 1 hit.
3.40.50.10190. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR017961. DNA_pol_Y-fam_little_finger.
IPR025527. DUF4414.
IPR012112. REV1.
IPR031991. Rev1_C.
IPR001126. UmuC.
[Graphical view]
PfamiPF16589. BRCT_2. 1 hit.
PF14377. DUF4414. 1 hit.
PF00817. IMS. 1 hit.
PF11799. IMS_C. 1 hit.
PF16727. REV1_C. 1 hit.
[Graphical view]
PIRSFiPIRSF036573. REV1. 1 hit.
SMARTiSM00292. BRCT. 1 hit.
[Graphical view]
SUPFAMiSSF100879. SSF100879. 1 hit.
SSF52113. SSF52113. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS50173. UMUC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Multiple roles of vertebrate REV genes in DNA repair and recombination."
    Okada T., Sonoda E., Yoshimura M., Kawano Y., Saya H., Kohzaki M., Takeda S.
    Mol. Cell. Biol. 25:6103-6111(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.

Entry informationi

Entry nameiREV1_CHICK
AccessioniPrimary (citable) accession number: Q4KWZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: August 2, 2005
Last modified: May 11, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.