1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase eta-1

Preferred order of sections

Names and origin

Protein names

Recommended name:
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase eta-1
EC=3.1.4.11

Alternative name(s):
Phosphoinositide phospholipase C-eta-1
Phospholipase C-eta-1
Short name=PLC-eta-1
Phospholipase C-like protein 3
Short name=PLC-L3

Gene names

Name:	PLCH1
Synonyms:	KIAA1069, PLCL3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1693 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes. Ref.1
Catalytic activity	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H₂O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Cofactor	Calcium.
Subcellular location	Cytoplasm. Membrane Ref.1.
Tissue specificity	Expressed in brain and to a lower extent in lung. In brain, it is found in cerebrum, cerebellum and spinal cord. Ref.1
Sequence similarities	Contains 1 C2 domain. Contains 2 EF-hand domains. Contains 1 PH domain. Contains 1 PI-PLC X-box domain. Contains 1 PI-PLC Y-box domain.
Sequence caution	The sequence BAB14129.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Lipid degradation
Cellular component	Cytoplasm Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat
Ligand	Calcium Metal-binding
Molecular function	Hydrolase Transducer
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW phosphatidylinositol-mediated signaling Inferred from direct assay Ref.1. Source: MGI
Cellular component	nuclear membrane Inferred from direct assay. Source: HPA
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro calcium-dependent phospholipase C activity Inferred from direct assay Ref.1. Source: MGI phosphatidylinositol phospholipase C activity Inferred from electronic annotation. Source: EC signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q4KWH8-1) Also known as: PLC-eta-1; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q4KWH8-2) The sequence of this isoform differs from the canonical sequence as follows: 1-18: Missing. 862-881: Missing.
Note: No experimental confirmation available.

Isoform 3 (identifier: Q4KWH8-3) Also known as: PLC-eta-1a; The sequence of this isoform differs from the canonical sequence as follows: 1000-1002: AED → VQI 1003-1693: Missing.

Isoform 4 (identifier: Q4KWH8-4) The sequence of this isoform differs from the canonical sequence as follows: 862-881: Missing. 1000-1034: AEDKDGRRKGKASIKDPHFLNFNKKLSSSSSALLH → DSSFCRPTEQAKAEMCKVPFPRQLECVMKMEISET 1035-1693: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1693

1693

1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase eta-1

PRO_0000329007

Regions

Domain

20 – 128

109

PH

Domain

142 – 177

36

EF-hand 1

Domain

178 – 214

37

EF-hand 2

Domain

299 – 444

146

PI-PLC X-box

Domain

601 – 714

114

PI-PLC Y-box

Domain

719 – 826

108

C2

Calcium binding

155 – 166

12

Potential

Compositional bias

1026 – 1030

5

Poly-Ser

Sites

Active site

314

1

By similarity

Active site

358

1

By similarity

Metal binding

315

1

Calcium 1; catalytic By similarity

Metal binding

344

1

Calcium 1; catalytic By similarity

Metal binding

346

1

Calcium 1; catalytic By similarity

Metal binding

393

1

Calcium 1; catalytic By similarity

Metal binding

758

1

Calcium 2; via carbonyl oxygen By similarity

Metal binding

760

1

Calcium 2 By similarity

Metal binding

784

1

Calcium 2 By similarity

Metal binding

813

1

Calcium 3 By similarity

Metal binding

814

1

Calcium 3; via carbonyl oxygen By similarity

Metal binding

815

1

Calcium 3 By similarity

Binding site

442

1

Substrate By similarity

Binding site

444

1

Substrate By similarity

Binding site

627

1

Substrate By similarity

Binding site

654

1

Substrate By similarity

Amino acid modifications

Modified residue

1307

1

Phosphoserine Ref.6

Modified residue

1494

1

Phosphoserine Ref.6

Natural variations

Alternative sequence

1 – 18

18

Missing in isoform 2.

VSP_032901

Alternative sequence

862 – 881

20

Missing in isoform 2 and isoform 4.

VSP_032902

Alternative sequence

1000 – 1034

35

AEDKD…SALLH → DSSFCRPTEQAKAEMCKVPF PRQLECVMKMEISET in isoform 4.

VSP_032903

Alternative sequence

1000 – 1002

3

AED → VQI in isoform 3.

VSP_032904

Alternative sequence

1003 – 1693

691

Missing in isoform 3.

VSP_032905

Alternative sequence

1035 – 1693

659

Missing in isoform 4.

VSP_032906

Sequences

Sequence		Length	Mass (Da)
Isoform 1 (PLC-eta-1) [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 00F2ADD21C4D14E6 Show »	FASTA	1,693	189,223
10 20 30 40 50 60 MADLEVYKNL SPEKVERCMS VMQSGTQMIK LKRGTKGLVR LFYLDEHRTR LRWRPSRKSE 70 80 90 100 110 120 KAKILIDSIY KVTEGRQSEI FHRQAEGNFD PSCCFTIYHG NHMESLDLIT SNPEEARTWI 130 140 150 160 170 180 TGLKYLMAGI SDEDSLAKRQ RTHDQWVKQT FEEADKNGDG LLNIEEIHQL MHKLNVNLPR 190 200 210 220 230 240 RKVRQMFQEA DTDENQGTLT FEEFCVFYKM MSLRRDLYLL LLSYSDKKDH LTVEELAQFL 250 260 270 280 290 300 KVEQKMNNVT TDYCLDIIKK FEVSEENKVK NVLGIEGFTN FMRSPACDIF NPLHHEVYQD 310 320 330 340 350 360 MDQPLCNYYI ASSHNTYLTG DQLLSQSKVD MYARVLQEGC RCVEVDCWDG PDGEPVVHHG 370 380 390 400 410 420 YTLTSKILFR DVVETINKHA FVKNEFPVIL SIENHCSIQQ QRKIAQYLKG IFGDKLDLSS 430 440 450 460 470 480 VDTGECKQLP SPQSLKGKIL VKGKKLPYHL GDDAEEGEVS DEDSADEIED ECKFKLHYSN 490 500 510 520 530 540 GTTEHQVESF IRKKLESLLK ESQIRDKEDP DSFTVRALLK ATHEGLNAHL KQSPDVKESG 550 560 570 580 590 600 KKSHGRSLMT NFGKHKKTTK SRSKSYSTDD EEDTQQSTGK EGGQLYRLGR RRKTMKLCRE 610 620 630 640 650 660 LSDLVVYTNS VAAQDIVDDG TTGNVLSFSE TRAHQVVQQK SEQFMIYNQK QLTRIYPSAY 670 680 690 700 710 720 RIDSSNFNPL PYWNAGCQLV ALNYQSEGRM MQLNRAKFKA NGNCGYVLKP QQMCKGTFNP 730 740 750 760 770 780 FSGDPLPANP KKQLILKVIS GQQLPKPPDS MFGDRGEIID PFVEVEIIGL PVDCCKDQTR 790 800 810 820 830 840 VVDDNGFNPV WEETLTFTVH MPEIALVRFL VWDHDPIGRD FVGQRTVTFS SLVPGYRHVY 850 860 870 880 890 900 LEGLTEASIF VHITINEIYG KWSPLILNPS YTILHFLGAT KNRQLQGLKG LFNKNPRHSS 910 920 930 940 950 960 SENNSHYVRK RSIGDRILRR TASAPAKGRK KSKMGFQEMV EIKDSVSEAT RDQDGVLRRT 970 980 990 1000 1010 1020 TRSLQARPVS MPVDRNLLGA LSLPVSETAK DIEGKENSLA EDKDGRRKGK ASIKDPHFLN 1030 1040 1050 1060 1070 1080 FNKKLSSSSS ALLHKDTSQG DTIVSTAHMS VTGEQLGMSS PRGGRTTSNA TSNCQENPCP 1090 1100 1110 1120 1130 1140 SKSLSPKQHL APDPVVNPTQ DLHGVKIKEK GNPEDFVEGK SILSGSVLSH SNLEIKNLEG 1150 1160 1170 1180 1190 1200 NRGKGRAATS FSLSDVSMLC SDIPDLHSTA ILQESVISHL IDNVTLTNEN EPGSSISALI 1210 1220 1230 1240 1250 1260 GQFDETNNQA LTVVSHLHNT SVMSGHCPLP SLGLKMPIKH GFCKGKSKSS FLCSSPELIA 1270 1280 1290 1300 1310 1320 LSSSETTKHA TNTVYETTCT PISKTKPDDD LSSKAKTAAL ESNLPGSPNT SRGWLPKSPT 1330 1340 1350 1360 1370 1380 KGEDWETLKS CSPASSPDLT LEDVIADPTL CFNSGESSLV EIDGESENLS LTTCEYRREG 1390 1400 1410 1420 1430 1440 TSQLASPLKL KYNQGVVEHF QRGLRNGYCK ETLRPSVPEI FNNIQDVKTQ SISYLAYQGA 1450 1460 1470 1480 1490 1500 GFVHNHFSDS DAKMFQTCVP QQSSAQDMHV PVPKQLAHLP LPALKLPSPC KSKSLGDLTS 1510 1520 1530 1540 1550 1560 EDIACNFESK YQCISKSFVT TGIRDKKGVT VKTKSLEPID ALTEQLRKLV SFDQEDNCQV 1570 1580 1590 1600 1610 1620 LYSKQDANQL PRALVRKLSS RSQSRVRNIA SRAKEKQEAN KQKVPNPSNG AGVVLRNKPS 1630 1640 1650 1660 1670 1680 APTPAVNRHS TGSYIAGYLK NTKGGGLEGR GIPEGACTAL HYGHVDQFCS DNSVLQTEPS 1690 SDDKPEIYFL LRL « Hide
Isoform 2 [UniParc]. Checksum: 42135E91A9064CEF Show »	FASTA	1,655	184,863
10 20 30 40 50 60 MSVMQSGTQM IKLKRGTKGL VRLFYLDEHR TRLRWRPSRK SEKAKILIDS IYKVTEGRQS 70 80 90 100 110 120 EIFHRQAEGN FDPSCCFTIY HGNHMESLDL ITSNPEEART WITGLKYLMA GISDEDSLAK 130 140 150 160 170 180 RQRTHDQWVK QTFEEADKNG DGLLNIEEIH QLMHKLNVNL PRRKVRQMFQ EADTDENQGT 190 200 210 220 230 240 LTFEEFCVFY KMMSLRRDLY LLLLSYSDKK DHLTVEELAQ FLKVEQKMNN VTTDYCLDII 250 260 270 280 290 300 KKFEVSEENK VKNVLGIEGF TNFMRSPACD IFNPLHHEVY QDMDQPLCNY YIASSHNTYL 310 320 330 340 350 360 TGDQLLSQSK VDMYARVLQE GCRCVEVDCW DGPDGEPVVH HGYTLTSKIL FRDVVETINK 370 380 390 400 410 420 HAFVKNEFPV ILSIENHCSI QQQRKIAQYL KGIFGDKLDL SSVDTGECKQ LPSPQSLKGK 430 440 450 460 470 480 ILVKGKKLPY HLGDDAEEGE VSDEDSADEI EDECKFKLHY SNGTTEHQVE SFIRKKLESL 490 500 510 520 530 540 LKESQIRDKE DPDSFTVRAL LKATHEGLNA HLKQSPDVKE SGKKSHGRSL MTNFGKHKKT 550 560 570 580 590 600 TKSRSKSYST DDEEDTQQST GKEGGQLYRL GRRRKTMKLC RELSDLVVYT NSVAAQDIVD 610 620 630 640 650 660 DGTTGNVLSF SETRAHQVVQ QKSEQFMIYN QKQLTRIYPS AYRIDSSNFN PLPYWNAGCQ 670 680 690 700 710 720 LVALNYQSEG RMMQLNRAKF KANGNCGYVL KPQQMCKGTF NPFSGDPLPA NPKKQLILKV 730 740 750 760 770 780 ISGQQLPKPP DSMFGDRGEI IDPFVEVEII GLPVDCCKDQ TRVVDDNGFN PVWEETLTFT 790 800 810 820 830 840 VHMPEIALVR FLVWDHDPIG RDFVGQRTVT FSSLVPGYRH VYLEGLTEAS IFVHITINEI 850 860 870 880 890 900 YGKNRQLQGL KGLFNKNPRH SSSENNSHYV RKRSIGDRIL RRTASAPAKG RKKSKMGFQE 910 920 930 940 950 960 MVEIKDSVSE ATRDQDGVLR RTTRSLQARP VSMPVDRNLL GALSLPVSET AKDIEGKENS 970 980 990 1000 1010 1020 LAEDKDGRRK GKASIKDPHF LNFNKKLSSS SSALLHKDTS QGDTIVSTAH MSVTGEQLGM 1030 1040 1050 1060 1070 1080 SSPRGGRTTS NATSNCQENP CPSKSLSPKQ HLAPDPVVNP TQDLHGVKIK EKGNPEDFVE 1090 1100 1110 1120 1130 1140 GKSILSGSVL SHSNLEIKNL EGNRGKGRAA TSFSLSDVSM LCSDIPDLHS TAILQESVIS 1150 1160 1170 1180 1190 1200 HLIDNVTLTN ENEPGSSISA LIGQFDETNN QALTVVSHLH NTSVMSGHCP LPSLGLKMPI 1210 1220 1230 1240 1250 1260 KHGFCKGKSK SSFLCSSPEL IALSSSETTK HATNTVYETT CTPISKTKPD DDLSSKAKTA 1270 1280 1290 1300 1310 1320 ALESNLPGSP NTSRGWLPKS PTKGEDWETL KSCSPASSPD LTLEDVIADP TLCFNSGESS 1330 1340 1350 1360 1370 1380 LVEIDGESEN LSLTTCEYRR EGTSQLASPL KLKYNQGVVE HFQRGLRNGY CKETLRPSVP 1390 1400 1410 1420 1430 1440 EIFNNIQDVK TQSISYLAYQ GAGFVHNHFS DSDAKMFQTC VPQQSSAQDM HVPVPKQLAH 1450 1460 1470 1480 1490 1500 LPLPALKLPS PCKSKSLGDL TSEDIACNFE SKYQCISKSF VTTGIRDKKG VTVKTKSLEP 1510 1520 1530 1540 1550 1560 IDALTEQLRK LVSFDQEDNC QVLYSKQDAN QLPRALVRKL SSRSQSRVRN IASRAKEKQE 1570 1580 1590 1600 1610 1620 ANKQKVPNPS NGAGVVLRNK PSAPTPAVNR HSTGSYIAGY LKNTKGGGLE GRGIPEGACT 1630 1640 1650 ALHYGHVDQF CSDNSVLQTE PSSDDKPEIY FLLRL « Hide
Isoform 3 (PLC-eta-1a) [UniParc]. Checksum: 333C3E46F453A55D Show »	FASTA	1,002	114,506
10 20 30 40 50 60 MADLEVYKNL SPEKVERCMS VMQSGTQMIK LKRGTKGLVR LFYLDEHRTR LRWRPSRKSE 70 80 90 100 110 120 KAKILIDSIY KVTEGRQSEI FHRQAEGNFD PSCCFTIYHG NHMESLDLIT SNPEEARTWI 130 140 150 160 170 180 TGLKYLMAGI SDEDSLAKRQ RTHDQWVKQT FEEADKNGDG LLNIEEIHQL MHKLNVNLPR 190 200 210 220 230 240 RKVRQMFQEA DTDENQGTLT FEEFCVFYKM MSLRRDLYLL LLSYSDKKDH LTVEELAQFL 250 260 270 280 290 300 KVEQKMNNVT TDYCLDIIKK FEVSEENKVK NVLGIEGFTN FMRSPACDIF NPLHHEVYQD 310 320 330 340 350 360 MDQPLCNYYI ASSHNTYLTG DQLLSQSKVD MYARVLQEGC RCVEVDCWDG PDGEPVVHHG 370 380 390 400 410 420 YTLTSKILFR DVVETINKHA FVKNEFPVIL SIENHCSIQQ QRKIAQYLKG IFGDKLDLSS 430 440 450 460 470 480 VDTGECKQLP SPQSLKGKIL VKGKKLPYHL GDDAEEGEVS DEDSADEIED ECKFKLHYSN 490 500 510 520 530 540 GTTEHQVESF IRKKLESLLK ESQIRDKEDP DSFTVRALLK ATHEGLNAHL KQSPDVKESG 550 560 570 580 590 600 KKSHGRSLMT NFGKHKKTTK SRSKSYSTDD EEDTQQSTGK EGGQLYRLGR RRKTMKLCRE 610 620 630 640 650 660 LSDLVVYTNS VAAQDIVDDG TTGNVLSFSE TRAHQVVQQK SEQFMIYNQK QLTRIYPSAY 670 680 690 700 710 720 RIDSSNFNPL PYWNAGCQLV ALNYQSEGRM MQLNRAKFKA NGNCGYVLKP QQMCKGTFNP 730 740 750 760 770 780 FSGDPLPANP KKQLILKVIS GQQLPKPPDS MFGDRGEIID PFVEVEIIGL PVDCCKDQTR 790 800 810 820 830 840 VVDDNGFNPV WEETLTFTVH MPEIALVRFL VWDHDPIGRD FVGQRTVTFS SLVPGYRHVY 850 860 870 880 890 900 LEGLTEASIF VHITINEIYG KWSPLILNPS YTILHFLGAT KNRQLQGLKG LFNKNPRHSS 910 920 930 940 950 960 SENNSHYVRK RSIGDRILRR TASAPAKGRK KSKMGFQEMV EIKDSVSEAT RDQDGVLRRT 970 980 990 1000 TRSLQARPVS MPVDRNLLGA LSLPVSETAK DIEGKENSLV QI « Hide
Isoform 4 [UniParc]. Checksum: 74AA8EB84E16050F Show »	FASTA	1,014	115,945
10 20 30 40 50 60 MADLEVYKNL SPEKVERCMS VMQSGTQMIK LKRGTKGLVR LFYLDEHRTR LRWRPSRKSE 70 80 90 100 110 120 KAKILIDSIY KVTEGRQSEI FHRQAEGNFD PSCCFTIYHG NHMESLDLIT SNPEEARTWI 130 140 150 160 170 180 TGLKYLMAGI SDEDSLAKRQ RTHDQWVKQT FEEADKNGDG LLNIEEIHQL MHKLNVNLPR 190 200 210 220 230 240 RKVRQMFQEA DTDENQGTLT FEEFCVFYKM MSLRRDLYLL LLSYSDKKDH LTVEELAQFL 250 260 270 280 290 300 KVEQKMNNVT TDYCLDIIKK FEVSEENKVK NVLGIEGFTN FMRSPACDIF NPLHHEVYQD 310 320 330 340 350 360 MDQPLCNYYI ASSHNTYLTG DQLLSQSKVD MYARVLQEGC RCVEVDCWDG PDGEPVVHHG 370 380 390 400 410 420 YTLTSKILFR DVVETINKHA FVKNEFPVIL SIENHCSIQQ QRKIAQYLKG IFGDKLDLSS 430 440 450 460 470 480 VDTGECKQLP SPQSLKGKIL VKGKKLPYHL GDDAEEGEVS DEDSADEIED ECKFKLHYSN 490 500 510 520 530 540 GTTEHQVESF IRKKLESLLK ESQIRDKEDP DSFTVRALLK ATHEGLNAHL KQSPDVKESG 550 560 570 580 590 600 KKSHGRSLMT NFGKHKKTTK SRSKSYSTDD EEDTQQSTGK EGGQLYRLGR RRKTMKLCRE 610 620 630 640 650 660 LSDLVVYTNS VAAQDIVDDG TTGNVLSFSE TRAHQVVQQK SEQFMIYNQK QLTRIYPSAY 670 680 690 700 710 720 RIDSSNFNPL PYWNAGCQLV ALNYQSEGRM MQLNRAKFKA NGNCGYVLKP QQMCKGTFNP 730 740 750 760 770 780 FSGDPLPANP KKQLILKVIS GQQLPKPPDS MFGDRGEIID PFVEVEIIGL PVDCCKDQTR 790 800 810 820 830 840 VVDDNGFNPV WEETLTFTVH MPEIALVRFL VWDHDPIGRD FVGQRTVTFS SLVPGYRHVY 850 860 870 880 890 900 LEGLTEASIF VHITINEIYG KNRQLQGLKG LFNKNPRHSS SENNSHYVRK RSIGDRILRR 910 920 930 940 950 960 TASAPAKGRK KSKMGFQEMV EIKDSVSEAT RDQDGVLRRT TRSLQARPVS MPVDRNLLGA 970 980 990 1000 1010 LSLPVSETAK DIEGKENSLD SSFCRPTEQA KAEMCKVPFP RQLECVMKME ISET « Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of a novel phospholipase C, PLC-eta." Hwang J.-I., Oh Y.-S., Shin K.-J., Kim H., Ryu S.H., Suh P.-G. Biochem. J. 389:181-186(2005) [PubMed: 15702972] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 926-1693 (ISOFORM 1). Tissue: Eye and Testis.
[3]	"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:197-205(1999) [PubMed: 10470851] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 216-1693 (ISOFORM 3). Tissue: Brain.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 392-1034 (ISOFORM 4).
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1470-1693 (ISOFORMS 1/2). Tissue: Testis.
[6]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1307 AND SER-1494, MASS SPECTROMETRY. Tissue: Embryonic kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY691170 mRNA. Translation: AAW22607.1. AY691171 mRNA. Translation: AAW22608.1. BC043248 mRNA. Translation: AAH43248.2. BC113950 mRNA. Translation: AAI13951.1. AB028992 mRNA. Translation: BAA83021.1. AK022610 mRNA. Translation: BAB14129.1. Different initiation. CR749869 mRNA. Translation: CAH18710.1.
IPI	IPI00175416. IPI00783616. IPI00848061. IPI00889624.
RefSeq	NP_001124432.1. NM_001130960.1. NP_001124433.1. NM_001130961.1. NP_055811.1. NM_014996.2.
UniGene	Hs.567423.
3D structure databases
HSSP	HSSP built from PDB template 1QAS based on UniProtKB P10688.
ProteinModelPortal	Q4KWH8.
SMR	Q4KWH8. Positions 19-890.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q4KWH8. 1 interaction.
STRING	Q4KWH8.
PTM databases
PhosphoSite	Q4KWH8.
Polymorphism databases
DMDM	121947010.
Proteomic databases
PRIDE	Q4KWH8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000340059; ENSP00000345988; ENSG00000114805.
GeneID	23007.
KEGG	hsa:23007.
UCSC	uc003fai.2. human. uc003faj.2. human. uc010hvs.1. human.
Organism-specific databases
CTD	23007.
GeneCards	GC03M155094.
HGNC	HGNC:29185. PLCH1.
HPA	HPA036176.
MIM	612835. gene.
neXtProt	NX_Q4KWH8.
PharmGKB	PA128394595.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG12321.
GeneTree	ENSGT00600000084266.
HOVERGEN	HBG095591.
InParanoid	Q4KWH8.
OMA	AYQGAGF.
PhylomeDB	Q4KWH8.
Enzyme and pathway databases
BRENDA	3.1.4.11. 2681.
Gene expression databases
ArrayExpress	Q4KWH8.
Bgee	Q4KWH8.
CleanEx	HS_PLCH1.
Genevestigator	Q4KWH8.
Family and domain databases
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR018029. C2_membr_targeting. IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR018249. EF_HAND_2. IPR002048. EF_hand_Ca-bd. IPR011993. PH_type. IPR001192. Pinositol_PLipase_C. IPR017946. PLC-like_Pdiesterase_TIM-brl. IPR001849. Pleckstrin_homology. IPR015359. PLipase_C_EF-hand-like. IPR000909. PLipase_C_PInositol-sp_X_dom. IPR001711. PLipase_C_Pinositol-sp_Y. [Graphical view]
Gene3D	G3DSA:1.10.238.10. EF-Hand_type. 3 hits. G3DSA:2.30.29.30. PH_type. 1 hit. G3DSA:3.20.20.190. PLC-like_Pdiesterase_TIM-brl. 2 hits.
Pfam	PF00168. C2. 1 hit. PF09279. efhand_like. 1 hit. PF00388. PI-PLC-X. 1 hit. PF00387. PI-PLC-Y. 1 hit. [Graphical view]
PRINTS	PR00390. PHPHLIPASEC.
SMART	SM00239. C2. 1 hit. SM00054. EFh. 2 hits. SM00233. PH. 1 hit. SM00148. PLCXc. 1 hit. SM00149. PLCYc. 1 hit. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 1 hit. SSF51695. PLC-like_Pdiesterase_TIM-brl. 1 hit.
PROSITE	PS50004. C2. 1 hit. PS00018. EF_HAND_1. 1 hit. PS50222. EF_HAND_2. 3 hits. PS50003. PH_DOMAIN. 1 hit. PS50007. PIPLC_X_DOMAIN. 1 hit. PS50008. PIPLC_Y_DOMAIN. 1 hit. [Graphical view]
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Other
NextBio	43921.
SOURCE	Search...

Entry information

Entry name

PLCH1_HUMAN

Accession

Primary (citable) accession number: Q4KWH8
Secondary accession number(s): Q29RV9

Q9UPT3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	August 2, 2005
Last modified:	January 25, 2012
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents