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Q4KWH5

- PLCH1_MOUSE

UniProt

Q4KWH5 - PLCH1_MOUSE

Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1

Gene

Plch1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (02 Aug 2005)
      Previous versions | rss
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    Functioni

    The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes.1 Publication

    Catalytic activityi

    1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

    Cofactori

    Calcium.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei314 – 3141PROSITE-ProRule annotation
    Metal bindingi315 – 3151Calcium 1; catalyticBy similarity
    Metal bindingi344 – 3441Calcium 1; catalyticBy similarity
    Metal bindingi346 – 3461Calcium 1; catalyticBy similarity
    Active sitei358 – 3581PROSITE-ProRule annotation
    Metal bindingi393 – 3931Calcium 1; catalyticBy similarity
    Binding sitei442 – 4421SubstrateBy similarity
    Binding sitei444 – 4441SubstrateBy similarity
    Binding sitei628 – 6281SubstrateBy similarity
    Binding sitei655 – 6551SubstrateBy similarity
    Metal bindingi759 – 7591Calcium 2; via carbonyl oxygenBy similarity
    Metal bindingi761 – 7611Calcium 2By similarity
    Metal bindingi785 – 7851Calcium 2By similarity
    Metal bindingi814 – 8141Calcium 3By similarity
    Metal bindingi815 – 8151Calcium 3; via carbonyl oxygenBy similarity
    Metal bindingi816 – 8161Calcium 3By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi155 – 16612PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium-dependent phospholipase C activity Source: MGI
    2. calcium ion binding Source: InterPro
    3. phosphatidylinositol phospholipase C activity Source: UniProtKB-EC
    4. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW
    2. phosphatidylinositol-mediated signaling Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Transducer

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    BRENDAi3.1.4.11. 3474.
    ReactomeiREACT_196473. Synthesis of IP3 and IP4 in the cytosol.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC:3.1.4.11)
    Alternative name(s):
    Phosphoinositide phospholipase C-eta-1
    Phospholipase C-eta-1
    Short name:
    PLC-eta-1
    Phospholipase C-like protein 3
    Short name:
    PLC-L3
    Gene namesi
    Name:Plch1
    Synonyms:Kiaa1069, Plcl3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:2683547. Plch1.

    Subcellular locationi

    Cytoplasm. Membrane By similarity

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. cytosol Source: MGI
    3. membrane Source: MGI
    4. nuclear membrane Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 168216821-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1PRO_0000329008Add
    BLAST

    Proteomic databases

    PaxDbiQ4KWH5.
    PRIDEiQ4KWH5.

    PTM databases

    PhosphoSiteiQ4KWH5.

    Expressioni

    Tissue specificityi

    Expressed in brain and to a lower extent in lung. In brain, it is found in cerebrum, cerebellum and spinal cord.1 Publication

    Gene expression databases

    BgeeiQ4KWH5.
    GenevestigatoriQ4KWH5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4KWH5.
    SMRiQ4KWH5. Positions 94-503, 601-858.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 128109PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini142 – 17736EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini178 – 21437EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini299 – 444146PI-PLC X-boxPROSITE-ProRule annotationAdd
    BLAST
    Domaini602 – 715114PI-PLC Y-boxPROSITE-ProRule annotationAdd
    BLAST
    Domaini720 – 827108C2PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi591 – 5944Poly-Arg
    Compositional biasi1027 – 10315Poly-Ser

    Sequence similaritiesi

    Contains 1 C2 domain.PROSITE-ProRule annotation
    Contains 2 EF-hand domains.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 1 PI-PLC X-box domain.PROSITE-ProRule annotation
    Contains 1 PI-PLC Y-box domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG149692.
    GeneTreeiENSGT00740000114979.
    HOGENOMiHOG000006871.
    HOVERGENiHBG095591.
    InParanoidiQ4KWH5.
    OMAiIEDECKF.
    PhylomeDBiQ4KWH5.
    TreeFamiTF313216.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    2.30.29.30. 1 hit.
    2.60.40.150. 1 hit.
    3.20.20.190. 2 hits.
    InterProiIPR000008. C2_dom.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001192. PI-PLC_fam.
    IPR028392. PLC-eta1.
    IPR017946. PLC-like_Pdiesterase_TIM-brl.
    IPR015359. PLipase_C_EF-hand-like.
    IPR000909. PLipase_C_PInositol-sp_X_dom.
    IPR001711. PLipase_C_Pinositol-sp_Y.
    [Graphical view]
    PANTHERiPTHR10336. PTHR10336. 1 hit.
    PTHR10336:SF51. PTHR10336:SF51. 1 hit.
    PfamiPF00168. C2. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    PF09279. EF-hand_like. 1 hit.
    PF00388. PI-PLC-X. 1 hit.
    PF00387. PI-PLC-Y. 1 hit.
    [Graphical view]
    PRINTSiPR00390. PHPHLIPASEC.
    SMARTiSM00239. C2. 1 hit.
    SM00054. EFh. 2 hits.
    SM00233. PH. 1 hit.
    SM00148. PLCXc. 1 hit.
    SM00149. PLCYc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 1 hit.
    SSF51695. SSF51695. 2 hits.
    PROSITEiPS50004. C2. 1 hit.
    PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 3 hits.
    PS50003. PH_DOMAIN. 1 hit.
    PS50007. PIPLC_X_DOMAIN. 1 hit.
    PS50008. PIPLC_Y_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q4KWH5-1) [UniParc]FASTAAdd to Basket

    Also known as: PLC-eta-1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MADLEVYKNL SPEKVERCMS VMQSGTQMIK LKRGTKGLVR LFYLDEHRTR     50
    LRWRPSRKSE KAKILIDSIY KVTEGRQSEI FHRQAEGNFD PSCCFTIYHG 100
    NHMESLDLIT SNPEEARTWI TGLKYLMAGI SDEDSLAKRQ RTHDQWVKQT 150
    FEEADKNGDG LLNIEEIHQL MHKLNVNLPR RKVRQMFQEA DTDENQGTLT 200
    FEEFCVFYKM MSLRRDLYLL LLSYSDKKDH LTVEELAQFL KVEQKMSNVT 250
    LDYCLDIIMK FEVSEENKVK NVLGIEGFTN FMRSPACDVF NPLHHEVYQD 300
    MDQPLCNYYI ASSHNTYLTG DQLLSQSKVD MYARVLQEGC RCVEVDCWDG 350
    PDGEPVVHHG YTLTSKILFR DVVETINKHA FVKNEFPVIL SIENHCSIQQ 400
    QRKIAQYLKG ILQDKLDLSS VDTGECRQLP SPQSLKGKIL VKGKKLPYHL 450
    GDDAEEGEVS DEDSADEIED ECKFKLHYSN GTTEHQVESF IRKKLESLLK 500
    ESQIRDKEDP DSFTVRALLK ATHEGLNAHL KQNLDVKESG KKSHGRSLMA 550
    NFGKHKQKAT KSRSKSYSTD DEDDSLQNPG KEGGQLYRLG RRRRTMKLCR 600
    ELSDLVVYTN SVAAQDIVDD GTTGNVLSFS ETRAHQVVQQ KSEQFMIYNQ 650
    KQLTRIYPSA YRIDSSNFNP LPYWNAGCQL VALNYQSEGR MMQINRAKFK 700
    ANGNCGYILK PQQMCKGTFN PFSGDPLPAN PKKQLILKVI SGQQLPKPPD 750
    SMFGDRGEII DPFVEVEIIG LPVDCCKDQT RVVDDNGFNP VWEETLTFTV 800
    HMPEIALVRF LVWDHDPIGR DFVGQRTVTF SSLVPGYRHV YLEGLTEASI 850
    FVHITINEIF GKWSPLILNP SYTILHFLGA TKNRQLQGLK GLFNKNPRHA 900
    SSENNSHYVR KRSIGDRILR RTASAPAKGR KKSKVGFQEM VEIKDSVSEA 950
    SRDQDGVLRR TTRSLQVRPV SMPVDKSLLG ALSLPISEAA KDTDGKENCL 1000
    AGDKDDRRKG AATRKDPHFS NFNKKLSSSS SALLHKDANQ GPTASVSNPE 1050
    QCGGRGAKSE RIKPNMTNDC QENHNPPKFL SPRKHLALDP ATKGLQERLH 1100
    GMKTNEKEHA EGFLGEKSML SGSVLSQSSL EVENLEGSRA KGRAATSFSL 1150
    SDVSALCSDI PDLHSTAILQ DTEISNLIDD VTLTNENQSG SSISALIGQF 1200
    EESNHPANVT VVSHLSTSGA SGSAPFQTPF KHGLSQGNQK ASFLCSSPEL 1250
    NKLSSVETTK LANNAVPCGV IGSPISTPKP GDDPSDKAKT RVIEGNLPGF 1300
    PDASPGQFPK SPTHGEDHSQ VMNSPALSTE LAIEDIIADP ALSINSAESS 1350
    LVEIDGESEN LSLTTCDYRE EAPSQLVSPL KLQQSQEMVE HIQRGLRNGY 1400
    CKETLLPSEI FNNIPGVKNH SISHLTYQGA GFVYNHFSSS DAKTNQICEP 1450
    QQPRAPDMHA PTPTPSTHAP LAALKLPSPC KSKSLGDLTS EDIACNFESK 1500
    YQCISRSFVT NGIRDKSVTM KTKSLEPLDA LTEQLRKLVS FDQEDSCQVL 1550
    YSKQDVNQCP RALVRKLSSR SQSRVRNIAS RAKEKQEAGK QKAMAQSTRG 1600
    GVVLRSKPPA PALAVNRHST GSYIASYLRN MKAGGLEGRG IPEGACTALR 1650
    YGYMDQFCSD NSVLQTEPSS EDKPEIYFLL RL 1682
    Length:1,682
    Mass (Da):187,743
    Last modified:August 2, 2005 - v1
    Checksum:i84B1BA6B4B6378A4
    GO
    Isoform 2 (identifier: Q4KWH5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-21: Missing.
         557-557: Missing.
         863-882: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,640
    Mass (Da):182,937
    Checksum:iCF855C1012C31490
    GO
    Isoform 3 (identifier: Q4KWH5-3) [UniParc]FASTAAdd to Basket

    Also known as: PLC-eta-1b

    The sequence of this isoform differs from the canonical sequence as follows:
         1001-1073: AGDKDDRRKG...PNMTNDCQEN → DLNRKQRKQE...VQRVRGSNQI
         1074-1682: Missing.

    Show »
    Length:1,073
    Mass (Da):122,771
    Checksum:i8FCD04B59FF7E5A5
    GO
    Isoform 4 (identifier: Q4KWH5-4) [UniParc]FASTAAdd to Basket

    Also known as: PLC-eta-1a

    The sequence of this isoform differs from the canonical sequence as follows:
         1001-1003: AGD → VQI
         1004-1682: Missing.

    Show »
    Length:1,003
    Mass (Da):114,547
    Checksum:i14A27D8A1271B93C
    GO
    Isoform 5 (identifier: Q4KWH5-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-563: Missing.
         564-584: SKSYSTDDEDDSLQNPGKEGG → MDFFSLHFKTWAVTMSSCHQR
         863-882: Missing.
         1001-1073: AGDKDDRRKG...PNMTNDCQEN → DLNRKQRKQE...VQRVRGSNQI
         1074-1682: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:490
    Mass (Da):55,818
    Checksum:iA256A8AE91E6F253
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti373 – 38513VETIN…FVKNE → AIDRPWLCCCSLR in BAD32373. (PubMed:15368895)CuratedAdd
    BLAST
    Sequence conflicti523 – 5231H → D in BAD32373. (PubMed:15368895)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 563563Missing in isoform 5. 1 PublicationVSP_032907Add
    BLAST
    Alternative sequencei1 – 2121Missing in isoform 2. 2 PublicationsVSP_032908Add
    BLAST
    Alternative sequencei557 – 5571Missing in isoform 2. 2 PublicationsVSP_032909
    Alternative sequencei564 – 58421SKSYS…GKEGG → MDFFSLHFKTWAVTMSSCHQ R in isoform 5. 1 PublicationVSP_032910Add
    BLAST
    Alternative sequencei863 – 88220Missing in isoform 2 and isoform 5. 2 PublicationsVSP_032911Add
    BLAST
    Alternative sequencei1001 – 107373AGDKD…DCQEN → DLNRKQRKQETRMTEEREPQ LEKTHIFQISTKSYPPPPVR SSTKMPTKGQLPVYQTQNSV EDEVQRVRGSNQI in isoform 3 and isoform 5. 2 PublicationsVSP_032912Add
    BLAST
    Alternative sequencei1001 – 10033AGD → VQI in isoform 4. 1 PublicationVSP_032913
    Alternative sequencei1004 – 1682679Missing in isoform 4. 1 PublicationVSP_032914Add
    BLAST
    Alternative sequencei1074 – 1682609Missing in isoform 3 and isoform 5. 2 PublicationsVSP_032915Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY691172 mRNA. Translation: AAW22609.1.
    AY691173 mRNA. Translation: AAW22610.1.
    AY691174 mRNA. Translation: AAW22611.1.
    BC042549 mRNA. Translation: AAH42549.1.
    BC052372 mRNA. Translation: AAH52372.1.
    BC055005 mRNA. Translation: AAH55005.1.
    AK173095 mRNA. Translation: BAD32373.1.
    CCDSiCCDS38444.2. [Q4KWH5-1]
    CCDS50918.1. [Q4KWH5-3]
    CCDS57215.1. [Q4KWH5-4]
    RefSeqiNP_001171203.1. NM_001177732.1. [Q4KWH5-4]
    NP_001171204.1. NM_001177733.1. [Q4KWH5-3]
    NP_899014.2. NM_183191.3. [Q4KWH5-1]
    UniGeneiMm.316391.

    Genome annotation databases

    EnsembliENSMUST00000084105; ENSMUSP00000081122; ENSMUSG00000036834. [Q4KWH5-1]
    ENSMUST00000159676; ENSMUSP00000124632; ENSMUSG00000036834. [Q4KWH5-3]
    ENSMUST00000162269; ENSMUSP00000124463; ENSMUSG00000036834. [Q4KWH5-4]
    GeneIDi269437.
    KEGGimmu:269437.
    UCSCiuc008pju.2. mouse. [Q4KWH5-5]
    uc008pjv.2. mouse. [Q4KWH5-2]
    uc008pjw.2. mouse. [Q4KWH5-3]
    uc008pjx.2. mouse. [Q4KWH5-4]
    uc008pjy.2. mouse. [Q4KWH5-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY691172 mRNA. Translation: AAW22609.1 .
    AY691173 mRNA. Translation: AAW22610.1 .
    AY691174 mRNA. Translation: AAW22611.1 .
    BC042549 mRNA. Translation: AAH42549.1 .
    BC052372 mRNA. Translation: AAH52372.1 .
    BC055005 mRNA. Translation: AAH55005.1 .
    AK173095 mRNA. Translation: BAD32373.1 .
    CCDSi CCDS38444.2. [Q4KWH5-1 ]
    CCDS50918.1. [Q4KWH5-3 ]
    CCDS57215.1. [Q4KWH5-4 ]
    RefSeqi NP_001171203.1. NM_001177732.1. [Q4KWH5-4 ]
    NP_001171204.1. NM_001177733.1. [Q4KWH5-3 ]
    NP_899014.2. NM_183191.3. [Q4KWH5-1 ]
    UniGenei Mm.316391.

    3D structure databases

    ProteinModelPortali Q4KWH5.
    SMRi Q4KWH5. Positions 94-503, 601-858.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q4KWH5.

    Proteomic databases

    PaxDbi Q4KWH5.
    PRIDEi Q4KWH5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000084105 ; ENSMUSP00000081122 ; ENSMUSG00000036834 . [Q4KWH5-1 ]
    ENSMUST00000159676 ; ENSMUSP00000124632 ; ENSMUSG00000036834 . [Q4KWH5-3 ]
    ENSMUST00000162269 ; ENSMUSP00000124463 ; ENSMUSG00000036834 . [Q4KWH5-4 ]
    GeneIDi 269437.
    KEGGi mmu:269437.
    UCSCi uc008pju.2. mouse. [Q4KWH5-5 ]
    uc008pjv.2. mouse. [Q4KWH5-2 ]
    uc008pjw.2. mouse. [Q4KWH5-3 ]
    uc008pjx.2. mouse. [Q4KWH5-4 ]
    uc008pjy.2. mouse. [Q4KWH5-1 ]

    Organism-specific databases

    CTDi 23007.
    MGIi MGI:2683547. Plch1.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG149692.
    GeneTreei ENSGT00740000114979.
    HOGENOMi HOG000006871.
    HOVERGENi HBG095591.
    InParanoidi Q4KWH5.
    OMAi IEDECKF.
    PhylomeDBi Q4KWH5.
    TreeFami TF313216.

    Enzyme and pathway databases

    BRENDAi 3.1.4.11. 3474.
    Reactomei REACT_196473. Synthesis of IP3 and IP4 in the cytosol.

    Miscellaneous databases

    ChiTaRSi PLCH1. mouse.
    NextBioi 392850.
    PROi Q4KWH5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q4KWH5.
    Genevestigatori Q4KWH5.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    2.30.29.30. 1 hit.
    2.60.40.150. 1 hit.
    3.20.20.190. 2 hits.
    InterProi IPR000008. C2_dom.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001192. PI-PLC_fam.
    IPR028392. PLC-eta1.
    IPR017946. PLC-like_Pdiesterase_TIM-brl.
    IPR015359. PLipase_C_EF-hand-like.
    IPR000909. PLipase_C_PInositol-sp_X_dom.
    IPR001711. PLipase_C_Pinositol-sp_Y.
    [Graphical view ]
    PANTHERi PTHR10336. PTHR10336. 1 hit.
    PTHR10336:SF51. PTHR10336:SF51. 1 hit.
    Pfami PF00168. C2. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    PF09279. EF-hand_like. 1 hit.
    PF00388. PI-PLC-X. 1 hit.
    PF00387. PI-PLC-Y. 1 hit.
    [Graphical view ]
    PRINTSi PR00390. PHPHLIPASEC.
    SMARTi SM00239. C2. 1 hit.
    SM00054. EFh. 2 hits.
    SM00233. PH. 1 hit.
    SM00148. PLCXc. 1 hit.
    SM00149. PLCYc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 1 hit.
    SSF51695. SSF51695. 2 hits.
    PROSITEi PS50004. C2. 1 hit.
    PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 3 hits.
    PS50003. PH_DOMAIN. 1 hit.
    PS50007. PIPLC_X_DOMAIN. 1 hit.
    PS50008. PIPLC_Y_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a novel phospholipase C, PLC-eta."
      Hwang J.-I., Oh Y.-S., Shin K.-J., Kim H., Ryu S.H., Suh P.-G.
      Biochem. J. 389:181-186(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3 AND 4), TISSUE SPECIFICITY, FUNCTION.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5).
      Tissue: Eye.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
      DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 373-1682 (ISOFORM 2).
      Tissue: Fetal brain.

    Entry informationi

    Entry nameiPLCH1_MOUSE
    AccessioniPrimary (citable) accession number: Q4KWH5
    Secondary accession number(s): Q4KWH6
    , Q4KWH7, Q69ZS3, Q7TPQ1, Q8CFQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: August 2, 2005
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3