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Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1

Gene

Plch1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes.1 Publication

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei314PROSITE-ProRule annotation1
Metal bindingi315Calcium 1; catalyticBy similarity1
Metal bindingi344Calcium 1; catalyticBy similarity1
Metal bindingi346Calcium 1; catalyticBy similarity1
Active sitei358PROSITE-ProRule annotation1
Metal bindingi393Calcium 1; catalyticBy similarity1
Binding sitei442SubstrateBy similarity1
Binding sitei444SubstrateBy similarity1
Binding sitei628SubstrateBy similarity1
Binding sitei655SubstrateBy similarity1
Metal bindingi759Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi761Calcium 2By similarity1
Metal bindingi785Calcium 2By similarity1
Metal bindingi814Calcium 3By similarity1
Metal bindingi815Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi816Calcium 3By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi155 – 166PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionHydrolase, Transducer
Biological processLipid degradation, Lipid metabolism
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.4.11. 3474.
ReactomeiR-MMU-1855204. Synthesis of IP3 and IP4 in the cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC:3.1.4.11)
Alternative name(s):
Phosphoinositide phospholipase C-eta-1
Phospholipase C-eta-1
Short name:
PLC-eta-1
Phospholipase C-like protein 3
Short name:
PLC-L3
Gene namesi
Name:Plch1
Synonyms:Kiaa1069, Plcl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2683547. Plch1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: MGI
  • intracellular membrane-bounded organelle Source: MGI
  • membrane Source: MGI

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003290081 – 16821-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1Add BLAST1682

Proteomic databases

PaxDbiQ4KWH5.
PeptideAtlasiQ4KWH5.
PRIDEiQ4KWH5.

PTM databases

iPTMnetiQ4KWH5.
PhosphoSitePlusiQ4KWH5.

Expressioni

Tissue specificityi

Expressed in brain and to a lower extent in lung. In brain, it is found in cerebrum, cerebellum and spinal cord.1 Publication

Gene expression databases

BgeeiENSMUSG00000036834.
ExpressionAtlasiQ4KWH5. baseline and differential.
GenevisibleiQ4KWH5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081122.

Structurei

3D structure databases

ProteinModelPortaliQ4KWH5.
SMRiQ4KWH5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 128PHPROSITE-ProRule annotationAdd BLAST109
Domaini142 – 177EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini178 – 214EF-hand 2PROSITE-ProRule annotationAdd BLAST37
Domaini299 – 444PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST146
Domaini602 – 715PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST114
Domaini720 – 827C2PROSITE-ProRule annotationAdd BLAST108

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi591 – 594Poly-Arg4
Compositional biasi1027 – 1031Poly-Ser5

Sequence similaritiesi

Contains 1 C2 domain.PROSITE-ProRule annotation
Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 PI-PLC X-box domain.PROSITE-ProRule annotation
Contains 1 PI-PLC Y-box domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0169. Eukaryota.
ENOG410XPSW. LUCA.
GeneTreeiENSGT00760000118936.
HOGENOMiHOG000006871.
HOVERGENiHBG095591.
InParanoidiQ4KWH5.
KOiK19006.
OMAiNGYCKET.
OrthoDBiEOG091G02KH.
PhylomeDBiQ4KWH5.
TreeFamiTF313216.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 2 hits.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001192. PI-PLC_fam.
IPR028392. PLC-eta1.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLC_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 3 hits.
PTHR10336:SF51. PTHR10336:SF51. 3 hits.
PfamiPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00054. EFh. 2 hits.
SM00233. PH. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF51695. SSF51695. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4KWH5-1) [UniParc]FASTAAdd to basket
Also known as: PLC-eta-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADLEVYKNL SPEKVERCMS VMQSGTQMIK LKRGTKGLVR LFYLDEHRTR
60 70 80 90 100
LRWRPSRKSE KAKILIDSIY KVTEGRQSEI FHRQAEGNFD PSCCFTIYHG
110 120 130 140 150
NHMESLDLIT SNPEEARTWI TGLKYLMAGI SDEDSLAKRQ RTHDQWVKQT
160 170 180 190 200
FEEADKNGDG LLNIEEIHQL MHKLNVNLPR RKVRQMFQEA DTDENQGTLT
210 220 230 240 250
FEEFCVFYKM MSLRRDLYLL LLSYSDKKDH LTVEELAQFL KVEQKMSNVT
260 270 280 290 300
LDYCLDIIMK FEVSEENKVK NVLGIEGFTN FMRSPACDVF NPLHHEVYQD
310 320 330 340 350
MDQPLCNYYI ASSHNTYLTG DQLLSQSKVD MYARVLQEGC RCVEVDCWDG
360 370 380 390 400
PDGEPVVHHG YTLTSKILFR DVVETINKHA FVKNEFPVIL SIENHCSIQQ
410 420 430 440 450
QRKIAQYLKG ILQDKLDLSS VDTGECRQLP SPQSLKGKIL VKGKKLPYHL
460 470 480 490 500
GDDAEEGEVS DEDSADEIED ECKFKLHYSN GTTEHQVESF IRKKLESLLK
510 520 530 540 550
ESQIRDKEDP DSFTVRALLK ATHEGLNAHL KQNLDVKESG KKSHGRSLMA
560 570 580 590 600
NFGKHKQKAT KSRSKSYSTD DEDDSLQNPG KEGGQLYRLG RRRRTMKLCR
610 620 630 640 650
ELSDLVVYTN SVAAQDIVDD GTTGNVLSFS ETRAHQVVQQ KSEQFMIYNQ
660 670 680 690 700
KQLTRIYPSA YRIDSSNFNP LPYWNAGCQL VALNYQSEGR MMQINRAKFK
710 720 730 740 750
ANGNCGYILK PQQMCKGTFN PFSGDPLPAN PKKQLILKVI SGQQLPKPPD
760 770 780 790 800
SMFGDRGEII DPFVEVEIIG LPVDCCKDQT RVVDDNGFNP VWEETLTFTV
810 820 830 840 850
HMPEIALVRF LVWDHDPIGR DFVGQRTVTF SSLVPGYRHV YLEGLTEASI
860 870 880 890 900
FVHITINEIF GKWSPLILNP SYTILHFLGA TKNRQLQGLK GLFNKNPRHA
910 920 930 940 950
SSENNSHYVR KRSIGDRILR RTASAPAKGR KKSKVGFQEM VEIKDSVSEA
960 970 980 990 1000
SRDQDGVLRR TTRSLQVRPV SMPVDKSLLG ALSLPISEAA KDTDGKENCL
1010 1020 1030 1040 1050
AGDKDDRRKG AATRKDPHFS NFNKKLSSSS SALLHKDANQ GPTASVSNPE
1060 1070 1080 1090 1100
QCGGRGAKSE RIKPNMTNDC QENHNPPKFL SPRKHLALDP ATKGLQERLH
1110 1120 1130 1140 1150
GMKTNEKEHA EGFLGEKSML SGSVLSQSSL EVENLEGSRA KGRAATSFSL
1160 1170 1180 1190 1200
SDVSALCSDI PDLHSTAILQ DTEISNLIDD VTLTNENQSG SSISALIGQF
1210 1220 1230 1240 1250
EESNHPANVT VVSHLSTSGA SGSAPFQTPF KHGLSQGNQK ASFLCSSPEL
1260 1270 1280 1290 1300
NKLSSVETTK LANNAVPCGV IGSPISTPKP GDDPSDKAKT RVIEGNLPGF
1310 1320 1330 1340 1350
PDASPGQFPK SPTHGEDHSQ VMNSPALSTE LAIEDIIADP ALSINSAESS
1360 1370 1380 1390 1400
LVEIDGESEN LSLTTCDYRE EAPSQLVSPL KLQQSQEMVE HIQRGLRNGY
1410 1420 1430 1440 1450
CKETLLPSEI FNNIPGVKNH SISHLTYQGA GFVYNHFSSS DAKTNQICEP
1460 1470 1480 1490 1500
QQPRAPDMHA PTPTPSTHAP LAALKLPSPC KSKSLGDLTS EDIACNFESK
1510 1520 1530 1540 1550
YQCISRSFVT NGIRDKSVTM KTKSLEPLDA LTEQLRKLVS FDQEDSCQVL
1560 1570 1580 1590 1600
YSKQDVNQCP RALVRKLSSR SQSRVRNIAS RAKEKQEAGK QKAMAQSTRG
1610 1620 1630 1640 1650
GVVLRSKPPA PALAVNRHST GSYIASYLRN MKAGGLEGRG IPEGACTALR
1660 1670 1680
YGYMDQFCSD NSVLQTEPSS EDKPEIYFLL RL
Length:1,682
Mass (Da):187,743
Last modified:August 2, 2005 - v1
Checksum:i84B1BA6B4B6378A4
GO
Isoform 2 (identifier: Q4KWH5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.
     557-557: Missing.
     863-882: Missing.

Note: No experimental confirmation available.
Show »
Length:1,640
Mass (Da):182,937
Checksum:iCF855C1012C31490
GO
Isoform 3 (identifier: Q4KWH5-3) [UniParc]FASTAAdd to basket
Also known as: PLC-eta-1b

The sequence of this isoform differs from the canonical sequence as follows:
     1001-1073: AGDKDDRRKG...PNMTNDCQEN → DLNRKQRKQE...VQRVRGSNQI
     1074-1682: Missing.

Show »
Length:1,073
Mass (Da):122,771
Checksum:i8FCD04B59FF7E5A5
GO
Isoform 4 (identifier: Q4KWH5-4) [UniParc]FASTAAdd to basket
Also known as: PLC-eta-1a

The sequence of this isoform differs from the canonical sequence as follows:
     1001-1003: AGD → VQI
     1004-1682: Missing.

Show »
Length:1,003
Mass (Da):114,547
Checksum:i14A27D8A1271B93C
GO
Isoform 5 (identifier: Q4KWH5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-563: Missing.
     564-584: SKSYSTDDEDDSLQNPGKEGG → MDFFSLHFKTWAVTMSSCHQR
     863-882: Missing.
     1001-1073: AGDKDDRRKG...PNMTNDCQEN → DLNRKQRKQE...VQRVRGSNQI
     1074-1682: Missing.

Note: No experimental confirmation available.
Show »
Length:490
Mass (Da):55,818
Checksum:iA256A8AE91E6F253
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti373 – 385VETIN…FVKNE → AIDRPWLCCCSLR in BAD32373 (PubMed:15368895).CuratedAdd BLAST13
Sequence conflicti523H → D in BAD32373 (PubMed:15368895).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0329071 – 563Missing in isoform 5. 1 PublicationAdd BLAST563
Alternative sequenceiVSP_0329081 – 21Missing in isoform 2. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_032909557Missing in isoform 2. 2 Publications1
Alternative sequenceiVSP_032910564 – 584SKSYS…GKEGG → MDFFSLHFKTWAVTMSSCHQ R in isoform 5. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_032911863 – 882Missing in isoform 2 and isoform 5. 2 PublicationsAdd BLAST20
Alternative sequenceiVSP_0329121001 – 1073AGDKD…DCQEN → DLNRKQRKQETRMTEEREPQ LEKTHIFQISTKSYPPPPVR SSTKMPTKGQLPVYQTQNSV EDEVQRVRGSNQI in isoform 3 and isoform 5. 2 PublicationsAdd BLAST73
Alternative sequenceiVSP_0329131001 – 1003AGD → VQI in isoform 4. 1 Publication3
Alternative sequenceiVSP_0329141004 – 1682Missing in isoform 4. 1 PublicationAdd BLAST679
Alternative sequenceiVSP_0329151074 – 1682Missing in isoform 3 and isoform 5. 2 PublicationsAdd BLAST609

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY691172 mRNA. Translation: AAW22609.1.
AY691173 mRNA. Translation: AAW22610.1.
AY691174 mRNA. Translation: AAW22611.1.
BC042549 mRNA. Translation: AAH42549.1.
BC052372 mRNA. Translation: AAH52372.1.
BC055005 mRNA. Translation: AAH55005.1.
AK173095 mRNA. Translation: BAD32373.1.
CCDSiCCDS38444.2. [Q4KWH5-1]
CCDS50918.1. [Q4KWH5-3]
CCDS57215.1. [Q4KWH5-4]
RefSeqiNP_001171203.1. NM_001177732.1. [Q4KWH5-4]
NP_001171204.1. NM_001177733.1. [Q4KWH5-3]
NP_899014.2. NM_183191.3. [Q4KWH5-1]
UniGeneiMm.316391.
Mm.488521.

Genome annotation databases

EnsembliENSMUST00000084105; ENSMUSP00000081122; ENSMUSG00000036834. [Q4KWH5-1]
ENSMUST00000159676; ENSMUSP00000124632; ENSMUSG00000036834. [Q4KWH5-3]
ENSMUST00000162269; ENSMUSP00000124463; ENSMUSG00000036834. [Q4KWH5-4]
GeneIDi269437.
KEGGimmu:269437.
UCSCiuc008pju.2. mouse. [Q4KWH5-5]
uc008pjv.2. mouse. [Q4KWH5-2]
uc033htw.1. mouse. [Q4KWH5-4]
uc033htx.1. mouse. [Q4KWH5-3]
uc033hty.1. mouse. [Q4KWH5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY691172 mRNA. Translation: AAW22609.1.
AY691173 mRNA. Translation: AAW22610.1.
AY691174 mRNA. Translation: AAW22611.1.
BC042549 mRNA. Translation: AAH42549.1.
BC052372 mRNA. Translation: AAH52372.1.
BC055005 mRNA. Translation: AAH55005.1.
AK173095 mRNA. Translation: BAD32373.1.
CCDSiCCDS38444.2. [Q4KWH5-1]
CCDS50918.1. [Q4KWH5-3]
CCDS57215.1. [Q4KWH5-4]
RefSeqiNP_001171203.1. NM_001177732.1. [Q4KWH5-4]
NP_001171204.1. NM_001177733.1. [Q4KWH5-3]
NP_899014.2. NM_183191.3. [Q4KWH5-1]
UniGeneiMm.316391.
Mm.488521.

3D structure databases

ProteinModelPortaliQ4KWH5.
SMRiQ4KWH5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081122.

PTM databases

iPTMnetiQ4KWH5.
PhosphoSitePlusiQ4KWH5.

Proteomic databases

PaxDbiQ4KWH5.
PeptideAtlasiQ4KWH5.
PRIDEiQ4KWH5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084105; ENSMUSP00000081122; ENSMUSG00000036834. [Q4KWH5-1]
ENSMUST00000159676; ENSMUSP00000124632; ENSMUSG00000036834. [Q4KWH5-3]
ENSMUST00000162269; ENSMUSP00000124463; ENSMUSG00000036834. [Q4KWH5-4]
GeneIDi269437.
KEGGimmu:269437.
UCSCiuc008pju.2. mouse. [Q4KWH5-5]
uc008pjv.2. mouse. [Q4KWH5-2]
uc033htw.1. mouse. [Q4KWH5-4]
uc033htx.1. mouse. [Q4KWH5-3]
uc033hty.1. mouse. [Q4KWH5-1]

Organism-specific databases

CTDi23007.
MGIiMGI:2683547. Plch1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0169. Eukaryota.
ENOG410XPSW. LUCA.
GeneTreeiENSGT00760000118936.
HOGENOMiHOG000006871.
HOVERGENiHBG095591.
InParanoidiQ4KWH5.
KOiK19006.
OMAiNGYCKET.
OrthoDBiEOG091G02KH.
PhylomeDBiQ4KWH5.
TreeFamiTF313216.

Enzyme and pathway databases

BRENDAi3.1.4.11. 3474.
ReactomeiR-MMU-1855204. Synthesis of IP3 and IP4 in the cytosol.

Miscellaneous databases

ChiTaRSiPlch1. mouse.
PROiQ4KWH5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036834.
ExpressionAtlasiQ4KWH5. baseline and differential.
GenevisibleiQ4KWH5. MM.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 2 hits.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001192. PI-PLC_fam.
IPR028392. PLC-eta1.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLC_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 3 hits.
PTHR10336:SF51. PTHR10336:SF51. 3 hits.
PfamiPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00054. EFh. 2 hits.
SM00233. PH. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF51695. SSF51695. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLCH1_MOUSE
AccessioniPrimary (citable) accession number: Q4KWH5
Secondary accession number(s): Q4KWH6
, Q4KWH7, Q69ZS3, Q7TPQ1, Q8CFQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: August 2, 2005
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.