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Protein
Submitted name:

Dual specificity mitogen-activated protein kinase kinase 4

Gene

Map2k4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • ATP binding Source: RGD
  • JUN kinase kinase activity Source: RGD
  • MAP kinase kinase activity Source: RGD
  • mitogen-activated protein kinase kinase kinase binding Source: RGD

GO - Biological processi

  • activation of JUN kinase activity Source: RGD
  • cell growth involved in cardiac muscle cell development Source: RGD
  • cellular response to sorbitol Source: RGD
  • JNK cascade Source: RGD
  • positive regulation of apoptotic process Source: RGD
  • positive regulation of DNA replication Source: RGD
  • positive regulation of neuron apoptotic process Source: RGD
  • positive regulation of nitric-oxide synthase biosynthetic process Source: RGD
  • positive regulation of protein phosphorylation Source: RGD
  • protein phosphorylation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Dual specificity mitogen-activated protein kinase kinase 4Imported
Gene namesi
Name:Map2k4Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi1307040. Map2k4.

Subcellular locationi

GO - Cellular componenti

  • axon Source: RGD
  • cytosol Source: RGD
  • dendrite cytoplasm Source: RGD
  • nucleus Source: RGD
  • perikaryon Source: RGD
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ4KSH6.
PRIDEiQ4KSH6.

PTM databases

iPTMnetiQ4KSH6.
PhosphoSiteiQ4KSH6.

Expressioni

Gene expression databases

GenevisibleiQ4KSH6. RN.

Interactioni

GO - Molecular functioni

  • mitogen-activated protein kinase kinase kinase binding Source: RGD

Protein-protein interaction databases

IntActiQ4KSH6. 3 interactions.
MINTiMINT-5055087.
STRINGi10116.ENSRNOP00000005293.

Chemistry

BindingDBiQ4KSH6.

Structurei

3D structure databases

ProteinModelPortaliQ4KSH6.
SMRiQ4KSH6. Positions 93-386.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini100 – 365266Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0984. Eukaryota.
ENOG410XT3F. LUCA.
HOGENOMiHOG000234206.
HOVERGENiHBG108518.
KOiK04430.
PhylomeDBiQ4KSH6.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4KSH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPSPSGGG GSGGGGGTPG PIGPPASGHP AVSSMQGKRK ALKLNFANPP
60 70 80 90 100
VKSTARFTLN PNTTGVQNPH IERLRTHSIE SSGKLKISPE QHWDFTAEDL
110 120 130 140 150
KDLGEIGRGA YGSVNKMVHK PSGQIMAVKR IRSTVDEKEQ KQLLMDLDVV
160 170 180 190 200
MRSSDCPYIV QFYGALFREG DCWICMELMS TSFDKFYKYV YSVLDDVIPE
210 220 230 240 250
EILGKITLAT VKALNHLKEN LKIIHRDIKP SNILLDRSGN IKLCDFGISG
260 270 280 290 300
QLVDSIAKTR DAGCRPYMAP ERIDPSASRQ GYDVRSDVWS LGITLYELAT
310 320 330 340 350
GRFPYPKWNS VFDQLTQVVK GDPPQLSNSE EREFSPSFIN FVNLCLTKDE
360 370 380 390
SKRPKYKELL KHPFILMYEE RTVEVACYVC KILDQMPATP SSPMYVD
Length:397
Mass (Da):44,114
Last modified:August 2, 2005 - v1
Checksum:iB99C6688184E5B3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY880882 mRNA. Translation: AAX61181.1.
RefSeqiNP_001025194.1. NM_001030023.1.
UniGeneiRn.198875.

Genome annotation databases

GeneIDi287398.
KEGGirno:287398.
UCSCiRGD:1307040. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY880882 mRNA. Translation: AAX61181.1.
RefSeqiNP_001025194.1. NM_001030023.1.
UniGeneiRn.198875.

3D structure databases

ProteinModelPortaliQ4KSH6.
SMRiQ4KSH6. Positions 93-386.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ4KSH6. 3 interactions.
MINTiMINT-5055087.
STRINGi10116.ENSRNOP00000005293.

Chemistry

BindingDBiQ4KSH6.

PTM databases

iPTMnetiQ4KSH6.
PhosphoSiteiQ4KSH6.

Proteomic databases

PaxDbiQ4KSH6.
PRIDEiQ4KSH6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi287398.
KEGGirno:287398.
UCSCiRGD:1307040. rat.

Organism-specific databases

CTDi6416.
RGDi1307040. Map2k4.

Phylogenomic databases

eggNOGiKOG0984. Eukaryota.
ENOG410XT3F. LUCA.
HOGENOMiHOG000234206.
HOVERGENiHBG108518.
KOiK04430.
PhylomeDBiQ4KSH6.

Miscellaneous databases

NextBioi626018.

Gene expression databases

GenevisibleiQ4KSH6. RN.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Itoh T., Horiuchi M., Itoh A.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.

Entry informationi

Entry nameiQ4KSH6_RAT
AccessioniPrimary (citable) accession number: Q4KSH6
Entry historyi
Integrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: May 11, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.