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Protein
Submitted name:

Dual specificity mitogen-activated protein kinase kinase 4

Gene

Map2k4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • ATP binding Source: RGD
  • JUN kinase kinase activity Source: RGD
  • MAP kinase kinase activity Source: RGD
  • mitogen-activated protein kinase kinase kinase binding Source: RGD
  • protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  • activation of JUN kinase activity Source: RGD
  • cell growth involved in cardiac muscle cell development Source: RGD
  • cellular response to sorbitol Source: RGD
  • JNK cascade Source: RGD
  • positive regulation of apoptotic process Source: RGD
  • positive regulation of DNA replication Source: RGD
  • positive regulation of neuron apoptotic process Source: RGD
  • positive regulation of nitric-oxide synthase biosynthetic process Source: RGD
  • positive regulation of protein phosphorylation Source: RGD
  • protein phosphorylation Source: RGD

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Dual specificity mitogen-activated protein kinase kinase 4Imported
Gene namesi
Name:Map2k4Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi1307040 Map2k4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiQ4KSH6

PTM databases

iPTMnetiQ4KSH6
PhosphoSitePlusiQ4KSH6

Expressioni

Gene expression databases

GenevisibleiQ4KSH6 RN

Interactioni

GO - Molecular functioni

  • mitogen-activated protein kinase kinase kinase binding Source: RGD

Protein-protein interaction databases

IntActiQ4KSH6, 3 interactors
MINTiQ4KSH6

Structurei

3D structure databases

ProteinModelPortaliQ4KSH6
SMRiQ4KSH6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini100 – 365Protein kinaseInterPro annotationAdd BLAST266

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0984 Eukaryota
ENOG410XT3F LUCA
HOGENOMiHOG000234206
HOVERGENiHBG108518
KOiK04430
PhylomeDBiQ4KSH6

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q4KSH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPSPSGGG GSGGGGGTPG PIGPPASGHP AVSSMQGKRK ALKLNFANPP
60 70 80 90 100
VKSTARFTLN PNTTGVQNPH IERLRTHSIE SSGKLKISPE QHWDFTAEDL
110 120 130 140 150
KDLGEIGRGA YGSVNKMVHK PSGQIMAVKR IRSTVDEKEQ KQLLMDLDVV
160 170 180 190 200
MRSSDCPYIV QFYGALFREG DCWICMELMS TSFDKFYKYV YSVLDDVIPE
210 220 230 240 250
EILGKITLAT VKALNHLKEN LKIIHRDIKP SNILLDRSGN IKLCDFGISG
260 270 280 290 300
QLVDSIAKTR DAGCRPYMAP ERIDPSASRQ GYDVRSDVWS LGITLYELAT
310 320 330 340 350
GRFPYPKWNS VFDQLTQVVK GDPPQLSNSE EREFSPSFIN FVNLCLTKDE
360 370 380 390
SKRPKYKELL KHPFILMYEE RTVEVACYVC KILDQMPATP SSPMYVD
Length:397
Mass (Da):44,114
Last modified:August 2, 2005 - v1
Checksum:iB99C6688184E5B3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY880882 mRNA Translation: AAX61181.1
RefSeqiNP_001025194.1, NM_001030023.1
UniGeneiRn.198875

Genome annotation databases

GeneIDi287398
KEGGirno:287398
UCSCiRGD:1307040 rat

Similar proteinsi

Entry informationi

Entry nameiQ4KSH6_RAT
AccessioniPrimary (citable) accession number: Q4KSH6
Entry historyiIntegrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: June 20, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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