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Protein

Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

Gene

NKAIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1
Short name:
Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 1
Alternative name(s):
Protein FAM77C
Gene namesi
Name:NKAIN1
Synonyms:FAM77C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25743. NKAIN1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 3413ExtracellularSequence analysisAdd
BLAST
Transmembranei35 – 5521HelicalSequence analysisAdd
BLAST
Topological domaini56 – 616CytoplasmicSequence analysis
Transmembranei62 – 8221HelicalSequence analysisAdd
BLAST
Topological domaini83 – 14664ExtracellularSequence analysisAdd
BLAST
Transmembranei147 – 16721HelicalSequence analysisAdd
BLAST
Topological domaini168 – 20740CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiNKAIN1.
DMDMi341942232.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 207186Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1PRO_0000412169Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ4KMZ8.
PRIDEiQ4KMZ8.

PTM databases

iPTMnetiQ4KMZ8.
PhosphoSiteiQ4KMZ8.

Expressioni

Gene expression databases

BgeeiQ4KMZ8.
CleanExiHS_NKAIN1.
ExpressionAtlasiQ4KMZ8. baseline and differential.
GenevisibleiQ4KMZ8. HS.

Organism-specific databases

HPAiHPA006873.

Interactioni

Subunit structurei

Interacts with ATP1B1 C-terminus.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000362841.

Structurei

3D structure databases

ProteinModelPortaliQ4KMZ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NKAIN family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4556. Eukaryota.
ENOG410XS8X. LUCA.
GeneTreeiENSGT00390000013699.
HOGENOMiHOG000293382.
HOVERGENiHBG108190.
InParanoidiQ4KMZ8.
OMAiCDGRCTL.
OrthoDBiEOG77DJ78.
PhylomeDBiQ4KMZ8.
TreeFamiTF321348.

Family and domain databases

InterProiIPR008516. Na/K-Atpase_Interacting.
[Graphical view]
PANTHERiPTHR13084. PTHR13084. 1 hit.
PfamiPF05640. NKAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4KMZ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKCSGRCTL VAFCCLQLVA ALERQIFDFL GYQWAPILAN FLHIMAVILG
60 70 80 90 100
IFGTVQYRSR YLILYAAWLV LWVGWNAFII CFYLEVGQLS QDRDFIMTFN
110 120 130 140 150
TSLHRSWWME NGPGCLVTPV LNSRLALEDH HVISVTGCLL DYPYIEALSS
160 170 180 190 200
ALQIFLALFG FVFACYVSKV FLEEEDSFDF IGGFDSYGYQ APQKTSHLQL

QPLYTSG
Length:207
Mass (Da):23,552
Last modified:July 27, 2011 - v3
Checksum:i5BDC3771B3E24E3E
GO
Isoform 2 (identifier: Q4KMZ8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: Missing.
     65-91: Missing.

Note: No experimental confirmation available.
Show »
Length:136
Mass (Da):15,436
Checksum:i3D5D16389B973CBE
GO

Sequence cautioni

The sequence AAH96707.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH98173.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH98249.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI31519.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14196.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAX07629.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti88 – 881Q → R in BAH13055 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4444Missing in isoform 2. 1 PublicationVSP_056113Add
BLAST
Alternative sequencei65 – 9127Missing in isoform 2. 1 PublicationVSP_056114Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022712 mRNA. Translation: BAB14196.1. Different initiation.
AK298874 mRNA. Translation: BAH12891.1.
AK299507 mRNA. Translation: BAH13055.1.
AC114495 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07629.1. Sequence problems.
BC096707 mRNA. Translation: AAH96707.2. Different initiation.
BC098173 mRNA. Translation: AAH98173.2. Different initiation.
BC098249 mRNA. Translation: AAH98249.2. Different initiation.
BC131518 mRNA. Translation: AAI31519.1. Different initiation.
CCDSiCCDS339.2. [Q4KMZ8-1]
RefSeqiNP_078798.2. NM_024522.2. [Q4KMZ8-1]
UniGeneiHs.470259.

Genome annotation databases

EnsembliENST00000373736; ENSP00000362841; ENSG00000084628. [Q4KMZ8-1]
GeneIDi79570.
KEGGihsa:79570.
UCSCiuc010ogd.3. human. [Q4KMZ8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022712 mRNA. Translation: BAB14196.1. Different initiation.
AK298874 mRNA. Translation: BAH12891.1.
AK299507 mRNA. Translation: BAH13055.1.
AC114495 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07629.1. Sequence problems.
BC096707 mRNA. Translation: AAH96707.2. Different initiation.
BC098173 mRNA. Translation: AAH98173.2. Different initiation.
BC098249 mRNA. Translation: AAH98249.2. Different initiation.
BC131518 mRNA. Translation: AAI31519.1. Different initiation.
CCDSiCCDS339.2. [Q4KMZ8-1]
RefSeqiNP_078798.2. NM_024522.2. [Q4KMZ8-1]
UniGeneiHs.470259.

3D structure databases

ProteinModelPortaliQ4KMZ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000362841.

PTM databases

iPTMnetiQ4KMZ8.
PhosphoSiteiQ4KMZ8.

Polymorphism and mutation databases

BioMutaiNKAIN1.
DMDMi341942232.

Proteomic databases

PaxDbiQ4KMZ8.
PRIDEiQ4KMZ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373736; ENSP00000362841; ENSG00000084628. [Q4KMZ8-1]
GeneIDi79570.
KEGGihsa:79570.
UCSCiuc010ogd.3. human. [Q4KMZ8-1]

Organism-specific databases

CTDi79570.
GeneCardsiNKAIN1.
HGNCiHGNC:25743. NKAIN1.
HPAiHPA006873.
MIMi612871. gene.
neXtProtiNX_Q4KMZ8.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4556. Eukaryota.
ENOG410XS8X. LUCA.
GeneTreeiENSGT00390000013699.
HOGENOMiHOG000293382.
HOVERGENiHBG108190.
InParanoidiQ4KMZ8.
OMAiCDGRCTL.
OrthoDBiEOG77DJ78.
PhylomeDBiQ4KMZ8.
TreeFamiTF321348.

Miscellaneous databases

ChiTaRSiNKAIN1. human.
GenomeRNAii79570.
PROiQ4KMZ8.
SOURCEiSearch...

Gene expression databases

BgeeiQ4KMZ8.
CleanExiHS_NKAIN1.
ExpressionAtlasiQ4KMZ8. baseline and differential.
GenevisibleiQ4KMZ8. HS.

Family and domain databases

InterProiIPR008516. Na/K-Atpase_Interacting.
[Graphical view]
PANTHERiPTHR13084. PTHR13084. 1 hit.
PfamiPF05640. NKAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 35-207 (ISOFORM 1).

Entry informationi

Entry nameiNKAI1_HUMAN
AccessioniPrimary (citable) accession number: Q4KMZ8
Secondary accession number(s): A2VDJ3
, B7Z5F5, B7Z5W9, Q9H9M7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 85 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.