Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

Gene

NKAIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Protein family/group databases

TCDBi8.B.27.1.2. the na+k+-atpase beta-subunit interacting nkain (nkain) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1
Short name:
Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 1
Alternative name(s):
Protein FAM77C
Gene namesi
Name:NKAIN1
Synonyms:FAM77C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25743. NKAIN1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 34ExtracellularSequence analysisAdd BLAST13
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Topological domaini56 – 61CytoplasmicSequence analysis6
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 146ExtracellularSequence analysisAdd BLAST64
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 207CytoplasmicSequence analysisAdd BLAST40

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79570.
OpenTargetsiENSG00000084628.

Polymorphism and mutation databases

BioMutaiNKAIN1.
DMDMi341942232.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000041216922 – 207Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1Add BLAST186

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ4KMZ8.
PeptideAtlasiQ4KMZ8.
PRIDEiQ4KMZ8.

PTM databases

iPTMnetiQ4KMZ8.
PhosphoSitePlusiQ4KMZ8.

Expressioni

Gene expression databases

BgeeiENSG00000084628.
CleanExiHS_NKAIN1.
ExpressionAtlasiQ4KMZ8. baseline and differential.
GenevisibleiQ4KMZ8. HS.

Organism-specific databases

HPAiHPA006873.

Interactioni

Subunit structurei

Interacts with ATP1B1 C-terminus.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000362841.

Structurei

3D structure databases

ProteinModelPortaliQ4KMZ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NKAIN family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4556. Eukaryota.
ENOG410XS8X. LUCA.
GeneTreeiENSGT00390000013699.
HOGENOMiHOG000293382.
HOVERGENiHBG108190.
InParanoidiQ4KMZ8.
OMAiCDGRCTL.
OrthoDBiEOG091G0X6F.
PhylomeDBiQ4KMZ8.
TreeFamiTF321348.

Family and domain databases

InterProiView protein in InterPro
IPR008516. Na/K-Atpase_Interacting.
PANTHERiPTHR13084. PTHR13084. 1 hit.
PfamiView protein in Pfam
PF05640. NKAIN. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4KMZ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKCSGRCTL VAFCCLQLVA ALERQIFDFL GYQWAPILAN FLHIMAVILG
60 70 80 90 100
IFGTVQYRSR YLILYAAWLV LWVGWNAFII CFYLEVGQLS QDRDFIMTFN
110 120 130 140 150
TSLHRSWWME NGPGCLVTPV LNSRLALEDH HVISVTGCLL DYPYIEALSS
160 170 180 190 200
ALQIFLALFG FVFACYVSKV FLEEEDSFDF IGGFDSYGYQ APQKTSHLQL

QPLYTSG
Length:207
Mass (Da):23,552
Last modified:July 27, 2011 - v3
Checksum:i5BDC3771B3E24E3E
GO
Isoform 2 (identifier: Q4KMZ8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: Missing.
     65-91: Missing.

Note: No experimental confirmation available.
Show »
Length:136
Mass (Da):15,436
Checksum:i3D5D16389B973CBE
GO

Sequence cautioni

The sequence AAH96707 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH98173 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH98249 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI31519 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14196 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAX07629 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88Q → R in BAH13055 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0561131 – 44Missing in isoform 2. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_05611465 – 91Missing in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022712 mRNA. Translation: BAB14196.1. Different initiation.
AK298874 mRNA. Translation: BAH12891.1.
AK299507 mRNA. Translation: BAH13055.1.
AC114495 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07629.1. Sequence problems.
BC096707 mRNA. Translation: AAH96707.2. Different initiation.
BC098173 mRNA. Translation: AAH98173.2. Different initiation.
BC098249 mRNA. Translation: AAH98249.2. Different initiation.
BC131518 mRNA. Translation: AAI31519.1. Different initiation.
CCDSiCCDS339.2. [Q4KMZ8-1]
RefSeqiNP_078798.2. NM_024522.2. [Q4KMZ8-1]
UniGeneiHs.470259.

Genome annotation databases

EnsembliENST00000373736; ENSP00000362841; ENSG00000084628. [Q4KMZ8-1]
GeneIDi79570.
KEGGihsa:79570.
UCSCiuc010ogd.3. human. [Q4KMZ8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiNKAI1_HUMAN
AccessioniPrimary (citable) accession number: Q4KMZ8
Secondary accession number(s): A2VDJ3
, B7Z5F5, B7Z5W9, Q9H9M7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 27, 2011
Last modified: May 10, 2017
This is version 92 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families