ID IQCC_HUMAN Reviewed; 466 AA. AC Q4KMZ1; F5H7T8; Q4KMS3; Q4KMZ5; Q53FL2; Q5TFJ8; Q9NVS3; DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot. DT 03-APR-2007, sequence version 2. DT 27-MAR-2024, entry version 125. DE RecName: Full=IQ domain-containing protein C; GN Name=IQCC; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE RP [LARGE SCALE MRNA] OF 1-433 (ISOFORM 3). RC TISSUE=Caudate nucleus; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT CYS-209. RC TISSUE=Synovium; RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., RA Tanaka A., Yokoyama S.; RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANTS RP TYR-217 AND LEU-464. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-438, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). CC -!- INTERACTION: CC Q4KMZ1; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-12206419, EBI-10175300; CC Q4KMZ1; O75031: HSF2BP; NbExp=3; IntAct=EBI-12206419, EBI-7116203; CC Q4KMZ1; Q14145: KEAP1; NbExp=3; IntAct=EBI-12206419, EBI-751001; CC Q4KMZ1; Q2NL68: PROSER3; NbExp=3; IntAct=EBI-12206419, EBI-11336487; CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q4KMZ1-1; Sequence=Displayed; CC Name=2; CC IsoId=Q4KMZ1-2; Sequence=VSP_024176; CC Name=3; CC IsoId=Q4KMZ1-3; Sequence=VSP_046123; CC -!- SEQUENCE CAUTION: CC Sequence=AK307853; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK001409; BAA91674.1; -; mRNA. DR EMBL; AK307853; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; AK223272; BAD96992.1; -; mRNA. DR EMBL; AL049795; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC098250; AAH98250.1; -; mRNA. DR EMBL; BC098260; AAH98260.1; -; mRNA. DR EMBL; BC098317; AAH98317.1; -; mRNA. DR EMBL; BC098366; AAH98366.1; -; mRNA. DR CCDS; CCDS355.1; -. [Q4KMZ1-1] DR CCDS; CCDS53293.1; -. [Q4KMZ1-3] DR RefSeq; NP_001153514.1; NM_001160042.1. [Q4KMZ1-3] DR RefSeq; NP_060604.2; NM_018134.2. [Q4KMZ1-1] DR AlphaFoldDB; Q4KMZ1; -. DR BioGRID; 120843; 15. DR IntAct; Q4KMZ1; 7. DR STRING; 9606.ENSP00000442291; -. DR GlyGen; Q4KMZ1; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; Q4KMZ1; -. DR PhosphoSitePlus; Q4KMZ1; -. DR BioMuta; IQCC; -. DR DMDM; 143339942; -. DR jPOST; Q4KMZ1; -. DR MassIVE; Q4KMZ1; -. DR MaxQB; Q4KMZ1; -. DR PaxDb; 9606-ENSP00000442291; -. DR PeptideAtlas; Q4KMZ1; -. DR ProteomicsDB; 27589; -. DR ProteomicsDB; 62207; -. [Q4KMZ1-1] DR ProteomicsDB; 62208; -. [Q4KMZ1-2] DR Antibodypedia; 31251; 123 antibodies from 16 providers. DR DNASU; 55721; -. DR Ensembl; ENST00000291358.11; ENSP00000291358.6; ENSG00000160051.12. [Q4KMZ1-1] DR Ensembl; ENST00000537469.2; ENSP00000442291.1; ENSG00000160051.12. [Q4KMZ1-3] DR GeneID; 55721; -. DR KEGG; hsa:55721; -. DR MANE-Select; ENST00000291358.11; ENSP00000291358.6; NM_018134.3; NP_060604.2. DR UCSC; uc001bum.3; human. [Q4KMZ1-1] DR AGR; HGNC:25545; -. DR CTD; 55721; -. DR DisGeNET; 55721; -. DR GeneCards; IQCC; -. DR HGNC; HGNC:25545; IQCC. DR HPA; ENSG00000160051; Low tissue specificity. DR neXtProt; NX_Q4KMZ1; -. DR OpenTargets; ENSG00000160051; -. DR PharmGKB; PA134868161; -. DR VEuPathDB; HostDB:ENSG00000160051; -. DR eggNOG; ENOG502S8YC; Eukaryota. DR GeneTree; ENSGT00390000017195; -. DR HOGENOM; CLU_046548_0_0_1; -. DR InParanoid; Q4KMZ1; -. DR OMA; DHRAQTC; -. DR OrthoDB; 2972046at2759; -. DR PhylomeDB; Q4KMZ1; -. DR TreeFam; TF330928; -. DR PathwayCommons; Q4KMZ1; -. DR SignaLink; Q4KMZ1; -. DR BioGRID-ORCS; 55721; 40 hits in 1156 CRISPR screens. DR GenomeRNAi; 55721; -. DR Pharos; Q4KMZ1; Tdark. DR PRO; PR:Q4KMZ1; -. DR Proteomes; UP000005640; Chromosome 1. DR RNAct; Q4KMZ1; Protein. DR Bgee; ENSG00000160051; Expressed in vena cava and 202 other cell types or tissues. DR InterPro; IPR000048; IQ_motif_EF-hand-BS. DR InterPro; IPR042506; IQCC. DR PANTHER; PTHR16049; IQ DOMAIN-CONTAINING PROTEIN C; 1. DR PANTHER; PTHR16049:SF8; IQ DOMAIN-CONTAINING PROTEIN C; 1. DR PROSITE; PS50096; IQ; 1. DR Genevisible; Q4KMZ1; HS. PE 1: Evidence at protein level; KW Alternative splicing; Phosphoprotein; Reference proteome. FT CHAIN 1..466 FT /note="IQ domain-containing protein C" FT /id="PRO_0000282545" FT DOMAIN 6..35 FT /note="IQ" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116" FT REGION 105..157 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 214..233 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 238..310 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 394..466 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 106..130 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 131..149 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 238..253 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 282..296 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 416..434 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 436..450 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 438 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:23186163" FT VAR_SEQ 14 FT /note="Q -> QVRGRARGSQDFSFREIMGSRTWTSQRDATTFSPLTARQPLEIPAVP FT NRAEESWDPRTPCPARPHSHHTLAPDQGNGKSLK (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_046123" FT VAR_SEQ 231..466 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_024176" FT VARIANT 209 FT /note="F -> C (in dbSNP:rs3903683)" FT /evidence="ECO:0000269|Ref.2" FT /id="VAR_031411" FT VARIANT 217 FT /note="C -> Y (in dbSNP:rs12032332)" FT /evidence="ECO:0000269|PubMed:15489334" FT /id="VAR_031412" FT VARIANT 464 FT /note="P -> L (in dbSNP:rs41306593)" FT /evidence="ECO:0000269|PubMed:15489334" FT /id="VAR_031413" FT CONFLICT 201 FT /note="P -> S (in Ref. 1; BAA91674)" FT /evidence="ECO:0000305" SQ SEQUENCE 466 AA; 53032 MW; 7282732CE4FA4F83 CRC64; MEPELLVRKV SALQACVRGF LVRRQFQSLR AEYEAIVREV EGDLGTLQWT EGRIPRPRFL PEKAKSHQTW KAGDRVANPE QGLWNHFPCE ESEGEATWEE MVLKKSGESS ANQGSLCRDH SSWLQMKQNR KPSQEKTRDT TRMENPEATD QRLPHSQPQL QELQYHRSHL AMELLWLQQA INSRKEYLLL KQTLRSPEAG PIREEPRVFL EHGEQACERD QSQPSAPLED QSYRDRTTGE LEQEDDSCHR VKSPHRSPGS LATTQKNIAG AKCREPCYSK SGPPSSIPSN SQALGDRLTK GPDDGRQTFG GTCLLQMKIL EDQTPRGLKP RNHCPRKSRT QLSALYEDSN IKEMSPRKLD HKEPDCRTVR TQELGLSEDH IIWDGTLGGP EHSVLDLWRT KPPKGQAPTD RSSRDGTSNE PSHEGQKKQR TIPWRSKSPE ILSSTKAGCT GEEQWRGRPW KTEPPG //